Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction

Autor: Lamichhane, Rajan ^a, Mukherjee, Santanu ^b, Smolin, Nikolai ^c, Pauszek, Raymond F., III ^a, Bradley, Margret ^b, Sastri, Jaya ^d, Robia, Seth L. ^c, Millar, David ^a, Campbell, Edward M. ^{b, ⁎}

Publikováno v: In Virology January 2017 500:161-168

TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions

Autor: Lukic Zana, Hausmann Stéphane, Sebastian Sarah, Rucci Justin, Sastri Jaya, Robia Seth L, Luban Jeremy, Campbell Edward M

Publikováno v: Retrovirology, Vol 8, Iss 1, p 93 (2011)

Abstract Background The TRIM5 proteins are cellular restriction factors that prevent retroviral infection in a species-specific manner. Multiple experiments indicate that restriction activity requires accessory host factors, including E2-enzymes. To

Externí odkaz: https://doaj.org/article/afa2befe50b4428290679011217f484d

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TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.

Autor: Campbell EM; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA ecampbell@luc.edu bouamrf@mail.nih.gov., Weingart J; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA., Sette P; Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Disease, Bethesda, Maryland, USA., Opp S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Sastri J; Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Disease, Bethesda, Maryland, USA., O'Connor SK; Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Disease, Bethesda, Maryland, USA., Talley S; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA., Diaz-Griffero F; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Hirsch V; Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Disease, Bethesda, Maryland, USA., Bouamr F; Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Disease, Bethesda, Maryland, USA ecampbell@luc.edu bouamrf@mail.nih.gov.

Publikováno v: Journal of virology [J Virol] 2015 Dec 16; Vol. 90 (4), pp. 1849-57. Date of Electronic Publication: 2015 Dec 16 (Print Publication: 2016).