Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Sassan Hafizi"'
Publikováno v:
Applied Sciences, Vol 14, Iss 11, p 4796 (2024)
Approved medical face masks have been shown to prevent the spread of respiratory droplets associated with coronavirus transmission in specific settings. The primary goal of this study was to develop a new strategy to assess the filtering and transmis
Externí odkaz:
https://doaj.org/article/c2eabd6e5af9411795cc4acb7e3fa194
Publikováno v:
Cells, Vol 13, Iss 10, p 873 (2024)
The TAM receptor ligand Gas6 is known for regulating inflammatory and immune pathways in various organs including the brain. Gas6 becomes fully functional through the post-translational modification of multiple glutamic acid residues into γ-carboxyg
Externí odkaz:
https://doaj.org/article/f05013a7b5894bc9831dab573c66303a
Autor:
Emeric Merour, Hatem Hmidan, Corentine Marie, Pierre-Henri Helou, Haiyang Lu, Antoine Potel, Jean-Baptiste Hure, Adrien Clavairoly, Yi Ping Shih, Salman Goudarzi, Sebastien Dussaud, Philippe Ravassard, Sassan Hafizi, Su Hao Lo, Bassem A Hassan, Carlos Parras
Publikováno v:
eLife, Vol 11 (2022)
The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the cytos
Externí odkaz:
https://doaj.org/article/c032f3eb47ba4b0586ac73356e196c31
Autor:
Nour Al Kafri, Josefin Ahnström, Adrienn Teraz-Orosz, Ludovic Chaput, Natesh Singh, Bruno O. Villoutreix, Sassan Hafizi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101263- (2022)
The homologous proteins Gas6 and protein S (ProS1) are both natural ligands for the TAM (Tyro3, Axl, MerTK) receptor tyrosine kinases. ProS1 selectively activates Tyro3; however, the precise molecular interface of the ProS1-Tyro3 contact has not been
Externí odkaz:
https://doaj.org/article/6257772e87b84a9290bb11f7c5d146cd
Autor:
Nour Al Kafri, Sassan Hafizi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101111- (2021)
Tyro3 is a member of the TAM subfamily of receptor tyrosine kinases alongside Axl and MerTK, which are activated by homologous ligands Gas6 and protein S. The TAMs activate signalling pathways that mediate diverse functions including cell survival, p
Externí odkaz:
https://doaj.org/article/fa4f207688d74b0fbf08c76ed315a4f6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Background: Microglia are well known key regulators of neuroinflammation which feature in multiple neurodegenerative disorders. These cells survey the CNS and, under inflammatory conditions, become “activated” through stimulation of toll-like rec
Externí odkaz:
https://doaj.org/article/452068212a1549f59a44bb2821e7eef9
Autor:
Ling Ding, Yuning Yang, Yang Ge, Qin Lu, Zixing Yan, Xuzheng Chen, Jian Du, Sassan Hafizi, Xiaohui Xu, Jiannan Yao, Jian Liu, Zhiyun Cao, Nathaniel Weygant
Publikováno v:
Cancers, Vol 13, Iss 22, p 5729 (2021)
The approval of immune checkpoint inhibitors has expanded treatment options for renal cell carcinoma (RCC), but new therapies that target RCC stemness and promote anti-tumor immunity are needed. Previous findings demonstrate that doublecortin-like ki
Externí odkaz:
https://doaj.org/article/141c7b35b39544f5b2d62de24f2dbd28
Publikováno v:
Cells, Vol 10, Iss 12, p 3281 (2021)
Microglia and astrocytes are the main CNS glial cells responsible for the neuroinflammatory response, where they release a plethora of cytokines into the CNS inflammatory milieu. The TAM (Tyro3, Axl, Mer) receptors and their main ligand Gas6 are regu
Externí odkaz:
https://doaj.org/article/148a7ee322cd465994c4d3d164f97d67
Autor:
Jason C. Fleming, Jeongmin Woo, Karwan Moutasim, Christopher J. Hanley, Steven J. Frampton, Oliver Wood, Matthew Ward, Christopher H. Woelk, Christian H. Ottensmeier, Sassan Hafizi, Dae Kim, Gareth J. Thomas
Publikováno v:
Cancers, Vol 12, Iss 10, p 2963 (2020)
Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease treated with surgery and/or (chemo) radiotherapy, but up to 50% of patients with late-stage disease develop locoregional recurrence. Determining the mechanisms underpinning treat
Externí odkaz:
https://doaj.org/article/76eaf9e8e35c4815bfc006dc21b6342f
Autor:
Nasrollah Erfani, Mohammad Javad Fattahi, Mohammad Hossein Dabbaghmanesh, Mohammad Mehrazmay, Ahmad Monabati, Akbar Rasekhi Kazerouni, Sassan Hafizi, Abbas Ghaderi
Publikováno v:
Middle East Journal of Cancer, Vol 7, Iss 1, Pp 1-7 (2016)
Background: The phosphatidylinositol 3-kinase/Akt signaling pathway is recognized as a key driver of cancer cell survival and proliferation, and is often contingent upon an impairment of expression/function of the PTEN tumor suppressor, a negative
Externí odkaz:
https://doaj.org/article/dc798bd140f549e9853d29e127274b6c