Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sasmit S. Deshmukh"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0206338 (2019)
The native octameric structure of streptococcal enolase from Streptococcus pyogenes increasingly dissociates as amino acid residues are removed one by one from the carboxy-terminus. These truncations gradually convert native octameric enolase into mo
Externí odkaz:
https://doaj.org/article/49084ada2e01462d908bf3bc2be6c76c
Autor:
Sasmit S. Deshmukh, Wayne Williams, Jessie Rose Payne, Manjit Haer, Kristen Kalbfleisch, Ibrahim Durowoju, Marina Kirkitadze, Jessica Duprez
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 439-447 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Purpose The goal of this study was to characterize an acellular pertussis vaccine (Tdap) containing genetically modified pertussis toxin (gdPT) and TLR agonist adsorbed to AlOOH adjuvant. Methods Several analytical tools inclu
Purpose The goal of this study was to characterize an acellular pertussis vaccine (Tdap) containing genetically modified pertussis toxin (gdPT) and TLR agonist adsorbed to AlOOH adjuvant. Methods Several analytical tools inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735e6521a035760843cac5af0c24fbbe
http://www.sciencedirect.com/science/article/pii/S2001037020305481
http://www.sciencedirect.com/science/article/pii/S2001037020305481
Autor:
Ali, Samaei, Sasmit S, Deshmukh, Charles, Protheroe, Sarah, Nyéki, Rose-Ange, Tremblay-Ethier, László, Kálmán
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1864:148928
The influence of illumination history of native bacterial reaction centers (BRCs) on the ability of binding and photo-induced oxidation of manganous ions was investigated in the pH range between 8.0 and 9.4. Binding of manganous ions to a buried site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7b0e5f56e5c9cace30e78779522a5c
https://doi.org/10.1016/j.bbabio.2022.148928
https://doi.org/10.1016/j.bbabio.2022.148928
Autor:
Ulrich Schacht, Carmen Mei, Liliana M. Sampaleanu, Nicole Lazaris, Marina Kirkitadze, Shuxin Cong, James Cronin, Matthew Balmer, Sylvie Morin, Daniel Chapman, Sasmit S. Deshmukh, Katherine Drolet-Vives, Moriam O. Ore, Bruce Carpick
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1184-1194 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1184-1194 (2019)
Purpose Aluminum-based adjuvants including aluminum phosphate (AlPO4) are commonly used in many human vaccines to enhance immune response. The interaction between the antigen and adjuvant, including the physical adsorption of antigen, may play a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a91b17231a1a8e219974b19a3d4b8a
https://doi.org/10.1016/j.csbj.2019.08.003
https://doi.org/10.1016/j.csbj.2019.08.003
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88395 (2014)
The enolase from Streptococcus pyogenes (Str enolase F137L/E363G) is a homo-octamer shaped like a donut. Plasminogen (Pgn) is a monomeric protein composed of seven discrete separated domains organized into a lock washer. The enolase is known to bind
Externí odkaz:
https://doaj.org/article/0031b1a27f884444a4bd87dc0be8672d
Autor:
Kristen Kalbfleisch, Wayne Williams, Jessica Duprez, Bruce Carpick, Ibrahim Durowoju, Marina Kirkitadze, Moriam Ore, Sasmit S. Deshmukh, Sylvie Morin, Carmen Mei
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 14-20 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 14-20 (2019)
Purpose The goal of this study is to set an empirical baseline to map the structure-function relation of the antigens from the commercialized vaccine products. Methods To study the structural changes of protein antigens after adsorption several analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a83198cc939aa5e6ebfdb2610bac5a
http://europepmc.org/articles/PMC6297905
http://europepmc.org/articles/PMC6297905
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0206338 (2019)
PLoS ONE, Vol 14, Iss 1, p e0206338 (2019)
The native octameric structure of streptococcal enolase from Streptococcus pyogenes increasingly dissociates as amino acid residues are removed one by one from the carboxy-terminus. These truncations gradually convert native octameric enolase into mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff520b48429bd22dfe5722fc1a3d5b3
http://europepmc.org/articles/PMC6336276
http://europepmc.org/articles/PMC6336276
Autor:
L. Kálmán, Sasmit S. Deshmukh
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1861:148285
The influence of transition metal binding on the charge storage ability of native bacterial reaction centers (BRCs) was investigated. Binding of manganous ions uniquely prevented the light-induced conformational changes that would yield to long lifet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2d11850af746158e5a859ab9715c76
https://doi.org/10.1016/j.bbabio.2020.148285
https://doi.org/10.1016/j.bbabio.2020.148285
Autor:
Carmen Mei, Moriam Ore, Sasmit S. Deshmukh, Joan Bevilacqua, Ibrahim Durowoju, Marina Kirkitadze, Wayne Williams, Jessica Duprez, Bruce Carpick, Kristen Kalbfleisch, Sylvie Morin
1) Background: Traditionally, complex biological products such as vaccines presented unique challenges to implementation of even rudimentary characterization packages; thus, the product was defined almost exclusively by its manufacturing process. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e90bd6e977986e038b3a12769f8ed2
https://doi.org/10.20944/preprints201808.0284.v1
https://doi.org/10.20944/preprints201808.0284.v1
Autor:
Federico Webster Magcalas, Sasmit S. Deshmukh, Kristen N. Kalbfleisch, Bruce Carpick, Marina Kirkitadze
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 157
Tuberculosis (TB) is one of the leading causes of death worldwide, making the development of effective TB vaccines a global priority. A TB vaccine consisting of a recombinant fusion protein, H4, combined with a novel synthetic cationic adjuvant, IC31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cb78726a89f7372f61746c2032399d
https://pubmed.ncbi.nlm.nih.gov/29866391
https://pubmed.ncbi.nlm.nih.gov/29866391