Výsledky vyhledávání - "Saskia Zemolka"

Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol

Autor: Sven Frormann, B.Y. Kögel, Bernd Sundermann, Klaus Linz, Achim Kless, Helmut Sonnenschein, Wolfgang P. Schröder, Stefan Schunk, Werner Englberger, Derek Saunders, Hans Schick, Tieno Germann, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Stefan Oberbörsch, Stephanie Harlfinger

Publikováno v: ACS Medicinal Chemistry Letters. 5:857-862

In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fbb1f07a0eb7a8eeee56a55aa18175
https://doi.org/10.1021/ml500117c

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Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists

Autor: Tieno Germann, Bernd Sundermann, Sven Frormann, Helmut Sonnenschein, Hans Schick, Werner Englberger, B.Y. Kögel, Derek Saunders, Achim Kless, Klaus Linz, Stefan Oberbörsch, Stephanie Harlfinger, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Wolfgang P. Schröder, Stefan Schunk

Publikováno v: ACS Medicinal Chemistry Letters. 5:851-856

We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe90b0366ab101fe23bc576f011c77
https://doi.org/10.1021/ml500116x

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Identification of Suitable Ligands for a Transition Metal-Catalyzed Reaction: Screening of a Modular Ligand Library in the Enantioselective Hydroboration of Styrene

Autor: Hans-Günther Schmalz, Thorsten Fey, Florian Blume, Remo Kranich, Saskia Zemolka

Publikováno v: Advanced Synthesis & Catalysis. 344:868-883

Based on a general modular synthetic scheme, a variety of chiral bidentate P/P-, P/S-, P/N-, and P/Se-ligands is accessible in an efficient divergent manner starting from phenol or naphthol derived backbone systems. A library of 20 selected ligands w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ed95a8143909840d9559e42b5331bd
https://doi.org/10.1002/1615-4169(200209)344:8<868::aid-adsc868>3.0.co

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