Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Saskia Zemolka"'
Autor:
Sven Frormann, B.Y. Kögel, Bernd Sundermann, Klaus Linz, Achim Kless, Helmut Sonnenschein, Wolfgang P. Schröder, Stefan Schunk, Werner Englberger, Derek Saunders, Hans Schick, Tieno Germann, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Stefan Oberbörsch, Stephanie Harlfinger
Publikováno v:
ACS Medicinal Chemistry Letters. 5:857-862
In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fbb1f07a0eb7a8eeee56a55aa18175
https://doi.org/10.1021/ml500117c
https://doi.org/10.1021/ml500117c
Autor:
Tieno Germann, Bernd Sundermann, Sven Frormann, Helmut Sonnenschein, Hans Schick, Werner Englberger, B.Y. Kögel, Derek Saunders, Achim Kless, Klaus Linz, Stefan Oberbörsch, Stephanie Harlfinger, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Wolfgang P. Schröder, Stefan Schunk
Publikováno v:
ACS Medicinal Chemistry Letters. 5:851-856
We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe90b0366ab101fe23bc576f011c77
https://doi.org/10.1021/ml500116x
https://doi.org/10.1021/ml500116x
Publikováno v:
Advanced Synthesis & Catalysis. 344:868-883
Based on a general modular synthetic scheme, a variety of chiral bidentate P/P-, P/S-, P/N-, and P/Se-ligands is accessible in an efficient divergent manner starting from phenol or naphthol derived backbone systems. A library of 20 selected ligands w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ed95a8143909840d9559e42b5331bd
https://doi.org/10.1002/1615-4169(200209)344:8<868::aid-adsc868>3.0.co
https://doi.org/10.1002/1615-4169(200209)344:8<868::aid-adsc868>3.0.co
Publikováno v:
Angewandte Chemie. 114:2635-2638
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc0dd9298b784bf8063fb01662c41dc
https://doi.org/10.1002/1521-3757(20020715)114:14<2635::aid-ange2635>3.0.co
https://doi.org/10.1002/1521-3757(20020715)114:14<2635::aid-ange2635>3.0.co
Publikováno v:
Angewandte Chemie International Edition. 41:2525-2528
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::388ebb4ba857113b0b23b0b5d13248c1
https://doi.org/10.1002/1521-3773(20020715)41:14<2525::aid-anie2525>3.0.co
https://doi.org/10.1002/1521-3773(20020715)41:14<2525::aid-anie2525>3.0.co
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ad8ebf2c224ab0c3cc4fde19a6ad17c
https://doi.org/10.1002/chin.200243080
https://doi.org/10.1002/chin.200243080
Publikováno v:
Angewandte Chemie (International ed. in English). 41(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2e2f65c5367b5ba213f68d06161fa61
https://pubmed.ncbi.nlm.nih.gov/12203522
https://pubmed.ncbi.nlm.nih.gov/12203522
Publikováno v:
Advanced Synthesis & Catalysis; 2002, Vol. 344 Issue 8, p868-883, 16p
Publikováno v:
Angewandte Chemie International Edition; Jul2002, Vol. 41 Issue 14, p2525-2528, 4p