Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Saskia Sperber"'
Autor:
Robert Landsiedel, Daniela Hahn, Rainer Ossig, Sabrina Ritz, Lydia Sauer, Roland Buesen, Sascha Rehm, Wendel Wohlleben, Sibylle Groeters, Volker Strauss, Saskia Sperber, Haleluya Wami, Ulrich Dobrindt, Karola Prior, Dag Harmsen, Bennard van Ravenzwaay, Juergen Schnekenburger
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-20 (2022)
Abstract Background The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but
Externí odkaz:
https://doaj.org/article/f44a66b7252642c58957e23656e01438
Autor:
Aishwarya Murali, Franziska Maria Zickgraf, Philipp Ternes, Varun Giri, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk Weyer, Shana J. Sturla, Ivonne M. G. M. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 533 (2023)
An understanding of the changes in gut microbiome composition and its associated metabolic functions is important to assess the potential implications thereof on host health. Thus, to elucidate the connection between the gut microbiome and the fecal
Externí odkaz:
https://doaj.org/article/6dbd09a7cbf24cec83d21f11e56bde9d
Autor:
Véronique de Bruijn, Christina Behr, Saskia Sperber, Tilmann Walk, Philipp Ternes, Markus Slopianka, Volker Haake, Karsten Beekmann, Bennard van Ravenzwaay
Publikováno v:
Metabolites, Vol 10, Iss 6, p 242 (2020)
Various environmental factors can alter the gut microbiome’s composition and functionality, and modulate host health. In this study, the effects of oral and parenteral administration of two poorly bioavailable antibiotics (i.e., vancomycin and stre
Externí odkaz:
https://doaj.org/article/a9b34ee77ea14fbaad96bf6d269fc6eb
Autor:
Aishwarya Murali, Varun Giri, Franziska Maria Zickgraf, Philipp Ternes, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk-Weyer, Shana J. Sturla, Ivonne M.C.M. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Chemical Research in Toxicology, 36(4), 598-616
Chemical Research in Toxicology 36 (2023) 4
Chemical Research in Toxicology 36 (2023) 4
The diversity of microbial species in the gut has a strong influence on health and development of the host. Further, there are indications that the variation in expression of gut bacterial metabolic enzymes is less diverse than the taxonomic profile,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fce8df1c24b9b508f189611f46ba892
https://doi.org/10.1021/acs.chemrestox.2c00316
https://doi.org/10.1021/acs.chemrestox.2c00316
Autor:
Barbara Birk, Tilmann B. Walk, H.-A. Huener, Saskia Sperber, A. Verlohner, Michael Manfred Herold, Tzutzuy Ramirez Hernandez, Hennicke Kamp, Volker Haake, Bennard van Ravenzwaay, Meike M. Amma, Nicola J. Hewitt, Svenja K. Wallisch
Publikováno v:
Toxicology Letters. 353:43-59
We describe a strategy using an in vitro metabolomics assay with tubular rat NRK-52E cells to investigate the Modes of Action (MoAs) of nephrotoxic compounds. Chemicals were selected according to their MoAs based on literature information: acetaminop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312c9098ebcc0a34c19fa9c6bd565b10
https://doi.org/10.1016/j.toxlet.2021.09.011
https://doi.org/10.1016/j.toxlet.2021.09.011
Autor:
Robert, Landsiedel, Daniela, Hahn, Rainer, Ossig, Sabrina, Ritz, Lydia, Sauer, Roland, Buesen, Sascha, Rehm, Wendel, Wohlleben, Sibylle, Groeters, Volker, Strauss, Saskia, Sperber, Haleluya, Wami, Ulrich, Dobrindt, Karola, Prior, Dag, Harmsen, Bennard, van Ravenzwaay, Juergen, Schnekenburger
Publikováno v:
Lebensmittelchemie. 76
The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but also intestinal mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91736b9d2b7d09fec68a01691ccd91b9
https://doi.org/10.1002/lemi.202259269
https://doi.org/10.1002/lemi.202259269
Autor:
Hunter James Cameron, Hennicke Kamp, Tilmann B. Walk, Varun Giri, Aishwarya Murali, Bennard van Ravenzwaay, Christina Behr, Saskia Sperber
Publikováno v:
Microbiology Research
Volume 12
Issue 1
Pages 8-122
Volume 12
Issue 1
Pages 8-122
The gut microbiome is vital to the health and development of an organism, specifically in determining the host response to a chemical (drug) administration. To understand this, we investigated the effects of six antibiotic (AB) treatments (Streptomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dfc18e6d893995555b15dba4b1dbf2
https://doi.org/10.3390/microbiolres12010008
https://doi.org/10.3390/microbiolres12010008
Autor:
Aishwarya Murali, Varun Giri, Hunter James Cameron, Saskia Sperber, Franziska Maria Zickgraf, Volker Haake, Peter Driemert, Tilmann Walk, Hennicke Kamp, Ivonne MCM. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Food and Chemical Toxicology, 165
Food and Chemical Toxicology 165 (2022)
Food and Chemical Toxicology 165 (2022)
To elucidate if artificial sweeteners modify fecal bacterial composition and the fecal and plasma metabolomes, Wistar rats from both sexes were treated for 28 days with acesulfame potassium (40 and 120 mg/kg body weight) and saccharin (20 and 100 mg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ef681caf9434656576763608920a1f
https://research.wur.nl/en/publications/investigating-the-gut-microbiome-and-metabolome-following-treatme
https://research.wur.nl/en/publications/investigating-the-gut-microbiome-and-metabolome-following-treatme
Autor:
W. Mellert, T. Walk, E. Fabian, H. Kamp, Saskia Sperber, Xiaoqi Jiang, Jana Keller, Michael Manfred Herold, B. van Ravenzwaay, V. Strauss
Publikováno v:
Toxicology Letters. 301:42-52
For regulatory purposes prenatal developmental toxicity (OECD No. 414) studies are routinely performed in our laboratories. The suitability of metabolomics as technology to identify maternal toxicity in such studies was investigated. Plasma was sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693175701c7428bb077d5957692eda5f
https://doi.org/10.1016/j.toxlet.2018.10.032
https://doi.org/10.1016/j.toxlet.2018.10.032
Autor:
Barbara Birk, H. Kamp, M. Herold, V. Haake, B. van Ravenzwaay, Elke Richling, Saskia Sperber, S. Ramirez Hincapie, V Giri, A. Verlohner, R. Landsiedel, H.-A. Huener
Publikováno v:
Toxicology Letters. 350:S95-S96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ff40b09953fba149f7f9d5991083242
https://doi.org/10.1016/s0378-4274(21)00470-7
https://doi.org/10.1016/s0378-4274(21)00470-7