Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Saskia Nijmeijer"'
Autor:
Sabrina M de Munnik, Albert J Kooistra, Jody van Offenbeek, Saskia Nijmeijer, Chris de Graaf, Martine J Smit, Rob Leurs, Henry F Vischer
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124486 (2015)
Kaposi's sarcoma-associated herpesvirus-infected cells express the virally encoded G protein-coupled receptor ORF74. Although ORF74 is constitutively active, it binds human CXC chemokines that modulate this basal activity. ORF74-induced signaling has
Externí odkaz:
https://doaj.org/article/e1284cb91522435dba23c19a2737e031
Autor:
Eléonore W E Verweij, Henry F. Vischer, Rudi Prihandoko, Wimzy R Prabhata, Rob Leurs, Betty Al Araaj, Saskia Nijmeijer, Andrew B. Tobin
Publikováno v:
ACS Pharmacology and Translational Science, 3(2), 321-333. American Chemical Society
Verweij, E W E, Al Araaj, B, Prabhata, W R, Prihandoko, R, Nijmeijer, S, Tobin, A B, Leurs, R & Vischer, H F 2020, ' Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H 4 Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling ', ACS Pharmacology and Translational Science, vol. 3, no. 2, pp. 321-333 . https://doi.org/10.1021/acsptsci.0c00008
Verweij, E W E, Al Araaj, B, Prabhata, W R, Prihandoko, R, Nijmeijer, S, Tobin, A B, Leurs, R & Vischer, H F 2020, ' Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H 4 Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling ', ACS Pharmacology and Translational Science, vol. 3, no. 2, pp. 321-333 . https://doi.org/10.1021/acsptsci.0c00008
The histamine H4 receptor (H4R) activates Gαi-mediated signaling and recruits β-arrestin2 upon stimulation with histamine. β-Arrestins play a regulatory role in G protein-coupled receptor (GPCR) signaling by interacting with phosphorylated serine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe2187c2729b5ad1ccf20ea502ca06d
http://www.scopus.com/inward/record.url?scp=85088849349&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85088849349&partnerID=8YFLogxK
Individuals speaking multiple language have been asserted to have a cognitive advantage, perhaps specifically in the domain of selective attention, although this claim has recently been challenged. The diversity of multilingual experiences and use se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e53f51da3d66c092ca17cd6b477c3ab
https://doi.org/10.31234/osf.io/kuv7f
https://doi.org/10.31234/osf.io/kuv7f
Autor:
Rob Leurs, Henry F. Vischer, Marta Arimont, Chris de Graaf, Melanie van der Woude, Saskia Nijmeijer
Publikováno v:
Arimont, M, Van Der Woude, M, Leurs, R, Vischer, H F, De Graaf, C & Nijmeijer, S 2019, ' Identification of Key Structural Motifs Involved in 7 Transmembrane Signaling of Adhesion GPCRs ', ACS Pharmacology & Translational Science, vol. 2, no. 2, pp. 101-113 . https://doi.org/10.1021/acsptsci.8b00051
ACS Pharmacology & Translational Science, 2(2), 101-113. American Chemical Society
ACS Pharmacology & Translational Science, 2(2), 101-113. American Chemical Society
The adhesion class B2 family of G protein-coupled receptors (GPCRs) plays a key role in important physiological processes and their dysfunction is linked to brain malformations and tumorigenesis. Although information regarding their signaling propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af190338a86e1013cbdbe2d69cf324c
https://hdl.handle.net/1871.1/522d9fd8-0096-4243-8078-b04b2a0bd292
https://hdl.handle.net/1871.1/522d9fd8-0096-4243-8078-b04b2a0bd292
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Frontiers in Aging Neuroscience, 13:550180. Frontiers Media SA
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, 13:550180. Frontiers Media SA
Frontiers in Aging Neuroscience
Introduction: With aging comes a reduction of cognitive flexibility, which has been related to the development of late-life depression and progression of general cognitive decline. Several factors have been linked to attenuating such decline in cogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef339998e2d336540e666145453c12be
https://doi.org/10.3389/fnagi.2021.550180
https://doi.org/10.3389/fnagi.2021.550180
Autor:
Albert J. Kooistra, Henry F. Vischer, Eric E. J. Haaksma, Iwan J. P. de Esch, Sabine Schultes, Chris de Graaf, Rob Leurs, Saskia Nijmeijer
Publikováno v:
Journal of Chemical Information and Modeling, 55(5), 1030-44. American Chemical Society
Schultes, S, Kooistra, A J, Vischer, H F, Nijmeijer, S, Haaksma, E E J, Leurs, R, De Esch, I J P & de Graaf, C 2015, ' Combinatorial consensus scoring for ligand-based virtual fragment screening : A comparative case study for serotonin 5-HT 3 A, histamine H 1, and Histamine H 4 receptors ', Journal of Chemical Information and Modeling, vol. 55, no. 5, pp. 1030-44 . https://doi.org/10.1021/ci500694c
Schultes, S, Kooistra, A J, Vischer, H F, Nijmeijer, S, Haaksma, E E J, Leurs, R, De Esch, I J P & de Graaf, C 2015, ' Combinatorial consensus scoring for ligand-based virtual fragment screening : A comparative case study for serotonin 5-HT 3 A, histamine H 1, and Histamine H 4 receptors ', Journal of Chemical Information and Modeling, vol. 55, no. 5, pp. 1030-44 . https://doi.org/10.1021/ci500694c
In the current study we have evaluated the applicability of ligand-based virtual screening (LBVS) methods for the identification of small fragment-like biologically active molecules using different similarity descriptors and different consensus scori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611b3e6f59abc3b1adb5b49f05b77913
http://www.scopus.com/inward/record.url?scp=84930199617&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=84930199617&partnerID=8YFLogxK
Autor:
Jörg Hamann, Saskia Nijmeijer, Ines Liebscher, Tobias Langenhan, Kelly R. Monk, Torsten Schöneberg
Publikováno v:
Molecular Pharmacology, 88(3), 617-623. American Society for Pharmacology and Experimental Therapeutics
Monk, K R, Hamann, J, Langenhan, T, Nijmeijer, S, Schoneberg, T & Liebscher, I 2015, ' Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms ', Molecular Pharmacology, vol. 88, no. 3, pp. 617-623 . https://doi.org/10.1124/mol.115.098749
Monk, K R, Hamann, J, Langenhan, T, Nijmeijer, S, Schoneberg, T & Liebscher, I 2015, ' Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms ', Molecular Pharmacology, vol. 88, no. 3, pp. 617-623 . https://doi.org/10.1124/mol.115.098749
The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in humans. aGPCRs are characterized by their enormous size and complex modular structures. While the physiologic importance of many aGPCRs has been clearly demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26432abf70d355dcbbdce7bc3a8390d9
https://research.vu.nl/en/publications/3c3b6382-a96e-4657-9282-5ca79ad8eb1c
https://research.vu.nl/en/publications/3c3b6382-a96e-4657-9282-5ca79ad8eb1c
Publikováno v:
Handbook of experimental pharmacology. 234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0acfcb770d812b5df21a98111a299e96
https://pubmed.ncbi.nlm.nih.gov/28108809
https://pubmed.ncbi.nlm.nih.gov/28108809
Autor:
Steven J. Charlton, Elizabeth M. Rosethorne, Saskia Nijmeijer, Francesco Sirci, C de Graaf, Henry F. Vischer, Sabine Schultes, Rob Leurs, H Engelhardt
Publikováno v:
British Journal of Pharmacology. 170:78-88
Background and Purpose The histamine H4 receptor, originally thought to signal merely through Gαi proteins, has recently been shown to also recruit and signal via β-arrestin2. Following the discovery that the reference antagonist indolecarboxamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::341a81053d70955cb5443e158fd91c24
https://doi.org/10.1111/bph.12117
https://doi.org/10.1111/bph.12117
Autor:
A. C. Van De Stolpe, Maikel Wijtmans, Eric E. J. Haaksma, Henry F. Vischer, Rob Leurs, K Stachurski, I.J.P. de Esch, V Lusink, Saskia Nijmeijer, C de Graaf, Sabine Schultes, Harald Engelhardt
Publikováno v:
British Journal of Pharmacology. 170:89-100
Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H4 receptor suggests that the 2-amino group of these ligands interacts with glutamic acid residue E1825.46 in the transmembrane (TM) helix 5 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eea48802332ba9638cbb8c360cbae98
https://doi.org/10.1111/bph.12113
https://doi.org/10.1111/bph.12113