Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Saskia N. deWildt"'
Autor:
J. Porter Hunt, Samuel Dubinsky, Autumn M. McKnite, Kit Wun Kathy Cheung, Bianca D. vanGroen, Kathleen M. Giacomini, Saskia N. deWildt, Andrea N. Edginton, Kevin M. Watt
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 576-588 (2024)
Abstract Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may incorporate RT activity, but this
Externí odkaz:
https://doaj.org/article/7ff55455941a418ca3f7d873a040d3c9
Autor:
Britt A. E. Dhaenens, Fenna Mahler, Hannah Batchelor, Pamela Dicks, Segolene Gaillard, Begonya Nafria, Annette Kopp‐Schneider, Maria Alexandra Ribeiro, Matthias Schwab, Monika Sparber‐Sauer, Jonas Leubner, Saskia N. deWildt, Rianne Oostenbrink
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1458-1468 (2023)
Abstract Advice from multiple stakeholders is required to design the optimal pediatric clinical trial. We present recommendations for acquiring advice from trial experts and patients/caregivers, derived from advice meetings that were performed throug
Externí odkaz:
https://doaj.org/article/640a9c0eb9d34e10955815d0c9c47643
Autor:
Katharine Cheng, Fenna Mahler, Irja Lutsar, Begonya Nafria Escalera, Stefanie Breitenstein, Gilles Vassal, Joana Claverol, Nuria Noel Palacio, Ron Portman, Gavin Pope, Martijn Bakker, Tessa van derGeest, Mark A. Turner, Saskia N. deWildt, c4c Expert Group Leads
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 478-488 (2023)
Abstract Many medicines are used “off‐label” in children outside the terms of the license. Feasible pediatric clinical trials are a challenge to design. Conect4children (c4c) is an Innovative Medicines Initiative project to set up a pan‐Europ
Externí odkaz:
https://doaj.org/article/c0e2c9a0347a4e119c1b97f392a17d3d
Autor:
Eva J. Streekstra, Márton Kiss, Jeroen van denHeuvel, Johan Nicolaï, Petra van denBroek, Sanne M. B. I. Botden, Martijn W. J. Stommel, Lara vanRijssel, Anna‐Lena Ungell, Evita van deSteeg, Frans G. M. Russel, Saskia N. deWildt
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2392-2402 (2022)
Abstract Little is known about the impact of age on the processes governing human intestinal drug absorption. The Ussing chamber is a system to study drug transport across tissue barriers, but it has not been used to study drug absorption processes i
Externí odkaz:
https://doaj.org/article/19dc0c00bdde4a0c98ee0dc9ad49aa34
Autor:
Bianca D. vanGroen, Venkatesh Pilla Reddy, Justine Badée, Andrés Olivares‐Morales, Trevor N. Johnson, Johan Nicolaï, Pieter Annaert, Anne Smits, Saskia N. deWildt, Catherijne A. J. Knibbe, Loeckie deZwart
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 29-35 (2021)
On April 24, 2019, a symposium on Pediatric Pharmacokinetics and Dose Predictions was held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought together scientists from academia, industry, and clinical research organ
Externí odkaz:
https://doaj.org/article/690f10a798a64e0ea88774b713cf9363
Autor:
Bianca D. vanGroen, Chengpeng Bi, Roger Gaedigk, Vincent S. Staggs, Dick Tibboel, Saskia N. deWildt, J. Steven Leeder
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 509-519 (2020)
The hepatic influx transporter OATP1B1 (SLCO1B1) plays an important role in the disposition of endogenous substrates and drugs prescribed to children. Alternative splicing increases the diversity of protein products from > 90% of human genes and may
Externí odkaz:
https://doaj.org/article/9069fc736bc846cc8c626e5568d65a63
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 11-13 (2020)
Externí odkaz:
https://doaj.org/article/96ad8bb56795494db72b5ad76366f08d