Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.

Autor: Laurens F M Verscheijden, Carlijn H C Litjens, Jan B Koenderink, Ron H J Mathijssen, Marcel M Verbeek, Saskia N de Wildt, Frans G M Russel

Publikováno v: PLoS Computational Biology, Vol 17, Iss 3, p e1008786 (2021)

Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability,

Externí odkaz: https://doaj.org/article/453e7f115c204fa085ec5f77bb94a806

Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis.

Autor: Laurens F M Verscheijden, Jan B Koenderink, Saskia N de Wildt, Frans G M Russel

Publikováno v: PLoS Computational Biology, Vol 15, Iss 6, p e1007117 (2019)

Different pediatric physiologically-based pharmacokinetic (PBPK) models have been described incorporating developmental changes that influence plasma drug concentrations. Drug disposition into cerebrospinal fluid (CSF) is also subject to age-related

Externí odkaz: https://doaj.org/article/2821067b0bc043ab9c57c0e99109d14f

Propranolol or atenolol for the management of infantile hemangioma

Autor: Mireille M. Hermans, Suzanne G.M.A. Pasmans, Peter C.J. de Laat, Martijn G. Slieker, Elodie J. Mendels, Marlies de Graaf, Hester R. Langeveld, Renske Schappin, André B. Rietman, Corstiaan C. Breugem, Johannes M.P.J. Breur, Saskia N. de Wildt, Martine F. Raphael

Publikováno v: JAAD International, 11, 137-139. Elsevier Inc.
Hermans, M M, Pasmans, S G M A, de Laat, P C J, Slieker, M G, Mendels, E J, de Graaf, M, Langeveld, H R, Schappin, R, Rietman, A B, Breugem, C C, Breur, J M P J, de Wildt, S N & Raphael, M F 2023, ' Propranolol or atenolol for the management of infantile hemangioma : Implications for long-term health ', JAAD International, vol. 11, pp. 137-139 . https://doi.org/10.1016/j.jdin.2023.02.001
JAAD International, 11, pp. 137-139
JAAD International, 11, 137-139

Contains fulltext : 292430.pdf (Publisher’s version ) (Open Access) 01 juni 2023

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c3af25c51009e39a59d0e8a187ec72
https://doi.org/10.1016/j.jdin.2023.02.001

Proenkephalin A as a marker for glomerular filtration rate in critically ill children

Autor: Nori J.L. Smeets, Oliver Hartmann, Janin Schulte, Michiel F. Schreuder, Saskia N. de Wildt

Publikováno v: Clinical Chemistry and Laboratory Medicine, 61, 104-111
Clinical Chemistry and Laboratory Medicine, 61(1), 104-111. De Gruyter
Clinical Chemistry and Laboratory Medicine, 61, 1, pp. 104-111

Objectives Accurate determination of glomerular filtration rate (GFR) is important. Several endogenous biomarkers exist for estimating GFR, yet, they have limited accuracy, especially in the paediatric population. Proenkephalin A 119–159 (PENK) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4d4f3de9d715ea6f545849f8644413
https://pure.eur.nl/en/publications/eb3f7103-ca4c-4f6b-a4f1-2e19bac72ef7

Ontogeny Related Changes in the Pediatric Liver Metabolome

Autor: Christopher M. Wilson, Qian Li, Roger Gaedigk, Charlie Bi, Saskia N. de Wildt, J. Steven Leeder, Brooke L. Fridley

Publikováno v: Frontiers in Pediatrics, Vol 8 (2020)

Background: A major challenge in implementing personalized medicine in pediatrics is identifying appropriate drug dosages for children. The majority of drug dosing studies have been based on adult populations, often with modification of the dosing fo

Externí odkaz: https://doaj.org/article/2fd5768a718144779cf48dbb47a7fd69