Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Saskia M. Burm"'
Autor:
Johann S. deBono, Jeffrey R. Harris, Saskia M. Burm, Adriaan Vanderstichele, Mischa A. Houtkamp, Saida Aarass, Ruth Riisnaes, Ines Figueiredo, Daniel Nava Rodrigues, Rossitza Christova, Siel Olbrecht, Hans W. M. Niessen, Sigrid R. Ruuls, Danita H. Schuurhuis, Jeroen J. Lammerts van Bueren, Esther C. W. Breij, Ignace Vergote
Publikováno v:
Cancer Reports, Vol 6, Iss 2, Pp n/a-n/a (2023)
Abstract Background Elevated tissue factor (TF) expression, although restricted in normal tissue, has been reported in multiple solid cancers, and expression has been associated with poor prognosis. This manuscript compares TF expression across vario
Externí odkaz:
https://doaj.org/article/0e98ad51ac3645c9bafd82abf01d3681
Autor:
Vanessa Donega, Saskia M. Burm, Miriam E. van Strien, Emma J. van Bodegraven, Iryna Paliukhovich, Hanneke Geut, Wilma D. J. van de Berg, Ka Wan Li, August B. Smit, Onur Basak, Elly M. Hol
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract It is currently accepted that the human brain has a limited neurogenic capacity and an impaired regenerative potential. We have previously shown the existence of CD271-expressing neural stem cells (NSCs) in the subventricular zone (SVZ) of P
Externí odkaz:
https://doaj.org/article/933efd03d56347dda5c661a640f727b2
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Neuroinflammation is a common feature in neurodegenerative diseases and strategies to modulate neuroinflammatory processes are increasingly considered as therapeutic options. In such strategies, glia cells rather than neurons represent the cellular t
Externí odkaz:
https://doaj.org/article/8d5f595cbdc04c3aad305cbb6e972ed4
Autor:
Ignacio Melero, Maria Jure-Kunkel, Uğur Şahin, Tahamtan Ahmadi, Ulf Forssmann, Özlem Türeci, Kate Sasser, Eleni Lagkadinou, Gaurav Bajaj, Esther C.W. Breij, Sebastian Kreiter, David Satijn, Mustafa Diken, Mark Fereshteh, Edward N. van den Brink, Aras Toker, Theo S. Plantinga, Juliane Quinkhardt, Angelica Sette, Fulvia Vascotto, Dennis Verzijl, Eliana Stanganello, Saskia M. Burm, Theodora W. Salcedo, Bianca Sänger, Jordan M. Blum, Kristina B. Schoedel, Maria E. Rodriguez-Ruiz, Guzman Alonso, Patricia M. LoRusso, Emiliano Calvo, Corinne Maurice-Dror, Eytan Ben-Ami, Ravit Geva, Friederike Gieseke, Isil Altintas, Elena Garralda, Alexander Muik
Checkpoint inhibitors (CPI) have revolutionized the treatment paradigm for advanced solid tumors; however, there remains an opportunity to improve response rates and outcomes. In preclinical models, 4-1BB costimulation synergizes with CPIs targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77571654a67b8230111048825587e8ec
https://doi.org/10.1158/2159-8290.c.6549569
https://doi.org/10.1158/2159-8290.c.6549569
Autor:
Ignacio Melero, Maria Jure-Kunkel, Uğur Şahin, Tahamtan Ahmadi, Ulf Forssmann, Özlem Türeci, Kate Sasser, Eleni Lagkadinou, Gaurav Bajaj, Esther C.W. Breij, Sebastian Kreiter, David Satijn, Mustafa Diken, Mark Fereshteh, Edward N. van den Brink, Aras Toker, Theo S. Plantinga, Juliane Quinkhardt, Angelica Sette, Fulvia Vascotto, Dennis Verzijl, Eliana Stanganello, Saskia M. Burm, Theodora W. Salcedo, Bianca Sänger, Jordan M. Blum, Kristina B. Schoedel, Maria E. Rodriguez-Ruiz, Guzman Alonso, Patricia M. LoRusso, Emiliano Calvo, Corinne Maurice-Dror, Eytan Ben-Ami, Ravit Geva, Friederike Gieseke, Isil Altintas, Elena Garralda, Alexander Muik
Supplementary Figure from Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e568b16421048c1e79b8dfceca7e687
https://doi.org/10.1158/2159-8290.22541198.v1
https://doi.org/10.1158/2159-8290.22541198.v1
Autor:
Alexander Muik, Homer C Adams, Friederike Gieseke, Isil Altintas, Kristina B Schoedel, Jordan M Blum, Bianca Sänger, Saskia M Burm, Eliana Stanganello, Dennis Verzijl, Vanessa M Spires, Fulvia Vascotto, Aras Toker, Juliane Quinkhardt, Mark Fereshteh, Mustafa Diken, David P E Satijn, Sebastian Kreiter, Tahamtan Ahmadi, Esther C W Breij, Özlem Türeci, Kate Sasser, Ugur Sahin, Maria Jure-Kunkel
Publikováno v:
Journal for immunotherapy of cancer. 10(6)
BackgroundDespite the preclinical promise of CD40 and 4-1BB as immuno-oncology targets, clinical efforts evaluating CD40 and 4-1BB agonists as monotherapy have found limited success. DuoBody-CD40×4-1BB (GEN1042/BNT312) is a novel investigational Fc-
Autor:
Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W. Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P.E. Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esther C.W. Breij, Maria Jure-Kunkel, Ugur Sahin
Publikováno v:
Oncoimmunology. 11(1)
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients experience treatment resistance. In preclinical models 4-1BB co-stimulation synergizes with ICI by
Autor:
Johann S. de Bono, Jeffrey R. Harris, Saskia M. Burm, Adriaan Vanderstichele, Mischa A. Houtkamp, Saida Aarass, Ruth Riisnaes, Ines Figueiredo, Daniel Nava Rodrigues, Rossitza Christova, Siel Olbrecht, Hans W. M. Niessen, Sigrid R. Ruuls, Danita H. Schuurhuis, Jeroen J. Lammerts van Bueren, Esther C. W. Breij, Ignace Vergote
Publikováno v:
de Bono, J S, Harris, J R, Burm, S M, Vanderstichele, A, Houtkamp, M A, Aarass, S, Riisnaes, R, Figueiredo, I, Nava Rodrigues, D, Christova, R, Olbrecht, S, Niessen, H W M, Ruuls, S R, Schuurhuis, D H, Lammerts van Bueren, J J, Breij, E C W & Vergote, I 2022, ' Systematic study of tissue factor expression in solid tumors ', Cancer reports (Hoboken, N.J.) . https://doi.org/10.1002/cnr2.1699
Cancer reports (Hoboken, N.J.). Wiley-Blackwell Publishing Ltd
Cancer reports (Hoboken, N.J.). Wiley-Blackwell Publishing Ltd
BACKGROUND: Elevated tissue factor (TF) expression, although restricted in normal tissue, has been reported in multiple solid cancers, and expression has been associated with poor prognosis. This manuscript compares TF expression across various solid
Autor:
Raissa Timmerman, Ella A. Zuiderwijk‐Sick, Nynke Oosterhof, Anke E. J. 't Jong, Jennifer Veth, Saskia M. Burm, Tjakko J. van Ham, Jeffrey J. Bajramovic
Publikováno v:
Glia, 70(4), 728-747. Wiley
GLIA, 70(4), 728-747. John Wiley & Sons Inc.
GLIA, 70(4), 728-747. John Wiley & Sons Inc.
Microglia are increasingly being recognized as druggable targets in neurodegenerative disorders, and good in vitro models are crucial to address cell biological questions. Major challenges are to recapitulate the complex microglial morphology and the
Autor:
Alexander Muik, Elena Garralda, Isil Altintas, Friederike Gieseke, Ravit Geva, Eytan Ben-Ami, Corinne Maurice-Dror, Emiliano Calvo, Patricia M. LoRusso, Guzman Alonso, Maria E. Rodriguez-Ruiz, Kristina B. Schoedel, Jordan M. Blum, Bianca Sänger, Theodora W. Salcedo, Saskia M. Burm, Eliana Stanganello, Dennis Verzijl, Fulvia Vascotto, Angelica Sette, Juliane Quinkhardt, Theo S. Plantinga, Aras Toker, Edward N. van den Brink, Mark Fereshteh, Mustafa Diken, David Satijn, Sebastian Kreiter, Esther C.W. Breij, Gaurav Bajaj, Eleni Lagkadinou, Kate Sasser, Özlem Türeci, Ulf Forssmann, Tahamtan Ahmadi, Uğur Şahin, Maria Jure-Kunkel, Ignacio Melero
Publikováno v:
Scientia
Checkpoint inhibitors (CPI) have revolutionized the treatment paradigm for advanced solid tumors; however, there remains an opportunity to improve response rates and outcomes. In preclinical models, 4-1BB costimulation synergizes with CPIs targeting