Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Saskia J.E. Suijkerbuijk"'
Autor:
Geert J.P.L. Kops, Nazneen Rahman, Sandra Hanks, Frank L. Bos, Maria H.J. van Osch, Saskia J.E. Suijkerbuijk
Supplementary Figures 1-5, Table 1 from Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e897a1e0c8d5a6c62cfee238d2b85e6
https://doi.org/10.1158/0008-5472.22382025.v1
https://doi.org/10.1158/0008-5472.22382025.v1
Autor:
Geert J.P.L. Kops, Nazneen Rahman, Sandra Hanks, Frank L. Bos, Maria H.J. van Osch, Saskia J.E. Suijkerbuijk
Genetic mutations in the mitotic regulatory kinase BUBR1 are associated with the cancer-susceptible disorder mosaic variegated aneuploidy (MVA). In patients with biallelic mutations, a missense mutation pairs with a truncating mutation. Here, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c481b3ee1a6293a4df9fe0fd45e4fbd7
https://doi.org/10.1158/0008-5472.c.6500073.v1
https://doi.org/10.1158/0008-5472.c.6500073.v1
Autor:
Jeroen M. Bugter, Layla El Bouazzaoui, Emre Küçükköse, Yourae Hong, Joep Sprangers, Ingrid Jordens, Nicola Fenderico, Diego Montiel Gonzalez, Ruben van Boxtel, Saskia J.E. Suijkerbuijk, Sabine Tejpar, Hugo J.G. Snippert, Onno Kranenburg, Madelon M. Maurice
SummaryIn colorectal cancer (CRC),RNF43mutations are linked to BRAF V600E-initiated serrated adenomas that advance into mucinous adenocarcinomas with poor prognosis upon metastasis. HowRNF43mutations facilitate a metastasis-prone growth state remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8cba2e1f0abcb057fa8c17979351af5
https://doi.org/10.1101/2022.12.22.521159
https://doi.org/10.1101/2022.12.22.521159
Autor:
Owen J. Sansom, Huy Quang Le, Jacco van Rheenen, Arianna Fumagalli, Rene Jackstadt, Tamsin Rosemary Margaret Lannagan, Saskia J.E. Suijkerbuijk, Ana Krotenberg Garcia
Publikováno v:
Cell Reports
Summary Competitive cell interactions play a crucial role in quality control during development and homeostasis. Here, we show that cancer cells use such interactions to actively eliminate wild-type intestine cells in enteroid monolayers and organoid
Autor:
Saskia I.J. Ellenbroek, Maria Azkanaz, Pim W. Toonen, Saskia J.E. Suijkerbuijk, Dustin J. Flanagan, Alexander James Hale, Owen J. Sansom, Hugo J. Snippert, Lotte Bruens, Jacco van Rheenen
Publikováno v:
Cell Reports
Summary Calorie restriction (CR) extends lifespan through several intracellular mechanisms, including increased DNA repair, leading to fewer DNA mutations that cause age-related pathologies. However, it remains unknown how CR acts on mutation retenti
Autor:
Saskia J.E. Suijkerbuijk, Evelyne Beerling, Hugo J. Snippert, Harry Begthel, Koen C. Oost, Jacco van Rheenen, Jarno Drost, Arianna Fumagalli
Publikováno v:
Nature Protocols
Nature Protocols, 13(2), 235. Nature Publishing Group
Nature Protocols, 13(2), 235. Nature Publishing Group
Most currently available colorectal cancer (CRC) mouse models are not suitable for studying progression toward the metastatic stage. Recently, establishment of tumor organoid lines, either from murine CRC models or patients, and the possibility of en
Publikováno v:
Developmental Biology, 428(2), 328. Academic Press Inc.
Developmental Biology
Developmental Biology, 428(2), 328-337. Academic Press
Developmental Biology
Developmental Biology, 428(2), 328-337. Academic Press
Homeostasis of tissues is tightly regulated at the cellular, tissue and organismal level. Interestingly, tumor cells have found ways to hijack many of these physiological processes at all the different levels. Here we review how intravital microscopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bd6b20f9b61b7ba5cfced2898e5e80
https://dspace.library.uu.nl/handle/1874/361449
https://dspace.library.uu.nl/handle/1874/361449
Autor:
Ruben van Boxtel, Owen J. Sansom, Joep de Ligt, Edwin Cuppen, G. Johan A. Offerhaus, Jacco van Rheenen, Jarno Drost, Harry Begthel, Hans Clevers, Arianna Fumagalli, Ee Hong Tan, Evelyne Beerling, Saskia J.E. Suijkerbuijk
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2357-E2364. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2357
Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2357-E2364. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2357
In the adenoma-carcinoma sequence, it is proposed that intestinal polyps evolve through a set of definedmutations toward metastatic colorectal cancer (CRC). Here, we dissect this adenoma-carcinoma sequence in vivo by using an orthotopic organoid tran
Publikováno v:
Developmental Cell. 23:745-755
SummaryMaintenance of chromosomal stability depends on error-free chromosome segregation. The pseudokinase BUBR1 is essential for this, because it is a core component of the mitotic checkpoint and is required for formation of stable kinetochore-micro
Autor:
Hugo J. Snippert, Arianna Fumagalli, S. Van der Elst, Saskia J.E. Suijkerbuijk, Evelyne Beerling, Jarno Drost, J. Van Rheenen
Publikováno v:
ESMO Open. 3:A12
Introduction Most currently available colorectal cancer (CRC) mouse models are not suitable for studying progression towards the metastatic stage of the disease. Recently, establishment of tumour organoid lines, either from murine CRC models or patie