Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Saskia Hulscher"'
1
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A
Autor: Linda Silvestri, Rogier A. Smits, Sarah C. R. Lummis, Andrew J. Thompson, Rob Leurs, Jacqueline E. van Muijlwijk-Koezen, Saskia Hulscher, Chris de Graaf, Obbe P. Zuiderveld, Gerdien E. de Kloe, Henry F. Vischer, Mark H.P. Verheij, Saskia Nijmeijer, Iwan J. P. de Esch
Publikováno v: Bioorganic & Medicinal Chemistry Letters
Graphical abstract
A fragment library was screened against the G protein-coupled histamine H4 receptor (H4R) and the ligand-gated ion channel serotonin 5-HT3A (5-HT3AR). Interestingly, significant overlap was found between H4R and 5-HT3AR hit se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52e42d222c6c62125893e7bac70bb4a
https://doi.org/10.1016/j.bmcl.2011.06.123
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2
Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28
Autor: Jane Victorina, Silvina A. Fratantoni, Rob Leurs, Martine J. Smit, Iwan J. P. de Esch, Saskia Hulscher, Mark H.P. Verheij, Henry F. Vischer, Janneke W. Hulshof
Publikováno v: Bioorganic and Medicinal Chemistry. Elsevier Limited
Vischer, H F, Hulshof, J W, Hulscher, ST, S.A., F, Verheij, V J, Smit, M J, de Esch, I J P & Leurs, R 2009, ' Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28 ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2009.11.060
Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco-modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might facilitate HCMV-associ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007bf636aa838d53bc10b65e2f07445e
https://doi.org/10.1016/j.bmc.2009.11.060
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3
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists
Autor: Bernard Christophe, Philippe P. Collart, Bastiaan J. Venhuis, Maikel Wijtmans, Saskia Hulscher, Benedicte Lallemand, Edith Gelens, Patrice Talaga, Iwan J. P. de Esch, Michel Gillard, Erwin Snip, Sylvain Celanire, Henk Timmerman, Rob Leurs, Henk van der Goot, Florence Lebon, Remko A. Bakker
Publikováno v: Wijtmans, M, Celanire, S, Snip, E, Gillard, M R, Gelens, E, Collart, P P, Venhuis, B J, Christophe, B, Hulscher, ST, van der Goot, H, Lebon, F, Timmerman, H, Bakker, R A, Leurs, R, Lallemand, B I, Talaga, P & de Esch, I J P 2008, ' 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists ', Journal of Medicinal Chemistry, vol. 51, no. 10, pp. 2944-53 . https://doi.org/10.1021/jm7014149
Journal of Medicinal Chemistry, 51(10), 2944-53. American Chemical Society
Research on the therapeutic applications of the histamine H3 receptor (H3R) has traditionally focused on antagonists/inverse agonists. In contrast, H3R agonists have received less attention despite their potential use in several disease areas. The lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd14a93395558ca6f0ff4ef04ac36c
https://research.vu.nl/en/publications/47ca4fc4-ef36-48d9-b4ba-e809e2b8d47c
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4
A Flow-Through Fluorescence Polarization Detection System for Measuring GPCR-Mediated Modulation of cAMP Production
Autor: André van Marle, Klaas van Altena, Hubertus Irth, Jeroen Kool, Maurice H. J. Selman, Saskia Hulscher, Remko A. Bakker, Michel Gillard, Rob Leurs, Nico P. E. Vermeulen, Dick J. van Iperen
Publikováno v: Kool, J, van Marle, A, Hulscher, ST, Selman, M, van Iperen, D J, van Altena, K, Gillard, M R, Bakker, R A, Irth, H, Leurs, R & Vermeulen, N P E 2007, ' A flow-through fluorescence polarization detection system for measuring GPCR-mediated modulation of cAMP production ', Journal of Biomolecular Screening, vol. 12, no. 8, pp. 1074-83 . https://doi.org/10.1177/1087057107308881
Journal of Biomolecular Screening, 12(8), 1074-83. SAGE Publications Inc.
A flow-through fluorescence polarization (FP) detection system that makes use of a novel high-performance liquid chromatography (HPLC) fluorescence detector modified with polarization filters was developed. This flow-through FP detection system was e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612f90aded131aa3cfae1dbadea96988
https://doi.org/10.1177/1087057107308881
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5
Effect of the insecticidal Galanthus nivalis agglutinin on metabolism and the activities of brush border enzymes in the rat small intestine
Autor: Henno Hendriks, Arpad Pusztai, Willy J. Peumans, Els J. M. Van Damme, J. F. J. G. Koninkx, Saskia Hulscher, Susan Bardocz, Wouter Kok, George Grant
Publikováno v: The Journal of Nutritional Biochemistry. 7:677-682
With increasing use of lectin genes in crop plants to improve insect resistance, the dietary exposure of humans to lectins will rise and it is necessary to assess whether the presently most favored insecticidal lectin, Galanthus nivalis agglutinin, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3a7859aefa85f5b67d8a1412a3efd11
https://doi.org/10.1016/s0955-2863(96)00131-3
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6
Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist
Autor: Obbe P. Zuiderveld, Bernard Christophe, Erwin Snip, Ruengwit Kitbunnadaj, Edith Gelens, Wiro M. P. B. Menge, Sylvain Celanire, Michel Gillard, Henk Timmerman, Remko A. Bakker, Saskia Hulscher, Patrice Talaga, Rob Leurs
Publikováno v: Journal of medicinal chemistry. 47(10)
In this study, the piperidine ring of immepip and its analogues was replaced by a rigid heterocyclic pyridine ring. Many compounds in the series exhibit high affinity and agonist activity at the human histamine H(3) receptor. Particularly, the 4-pyri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec25a5b8acc244e0e7533c477d4660e5
https://pubmed.ncbi.nlm.nih.gov/15115383
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7
Evidence for a Role of p38 Kinase in Hypoxia-inducible Factor 1-independent Induction of Vascular Endothelial Growth Factor Expression by Sodium Arsenite
Autor: Monique C.A. Duyndam, Elsken van der Wall, Saskia Hulscher, Epie Boven, Herbert M. Pinedo
Publikováno v: The journal of biological chemistry, 278(9), 6885. The American Society for Biochemistry and Molecular Biology
Duyndam, M C A, Hulscher, ST, van der Wall, E, Pinedo, H M & Boven, E 2003, ' Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. ', Journal of Biological Chemistry, vol. 278, no. 9, pp. 6885-95 . https://doi.org/10.1074/jbc.M206320200
Journal of Biological Chemistry, 278(9), 6885-95. American Society for Biochemistry and Molecular Biology Inc.
Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells. We now show that arsenic trioxide,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1009318f968fa361b4d3bd18406c48a
https://dspace.library.uu.nl/handle/1874/21630
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