Výsledky vyhledávání - "Saskia Hoffmann"

Akademický článek

VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

Autor: Ann Schirin Mirsanaye, Saskia Hoffmann, Melanie Weisser, Andreas Mund, Blanca Lopez Mendez, Dimitris Typas, Johannes van den Boom, Bente Benedict, Ivo A. Hendriks, Michael Lund Nielsen, Hemmo Meyer, Julien P. Duxin, Guillermo Montoya, Niels Mailand

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ub

Externí odkaz: https://doaj.org/article/94acc0facb2c40838b11f84474d25e74

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Akademický článek

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Autor: Remi Sonneville, Rahul Bhowmick, Saskia Hoffmann, Niels Mailand, Ian D Hickson, Karim Labib

Publikováno v: eLife, Vol 8 (2019)

The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis wi

Externí odkaz: https://doaj.org/article/7a4bbbba579a45c4a2b6bfe82441f165

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Akademický článek

SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

Autor: David Walter, Saskia Hoffmann, Eirini-Stavroula Komseli, Juri Rappsilber, Vassilis Gorgoulis, Claus Storgaard Sørensen

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.

Externí odkaz: https://doaj.org/article/ea2c7f82640b4cec8dd591558f03042e

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Akademický článek

p53 and cell cycle dependent transcription of kinesin family member 23 (KIF23) is controlled via a CHR promoter element bound by DREAM and MMB complexes.

Autor: Martin Fischer, Inga Grundke, Sindy Sohr, Marianne Quaas, Saskia Hoffmann, Arne Knörck, Catalina Gumhold, Karen Rother

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63187 (2013)

The microtubule-dependent molecular motor KIF23 (Kinesin family member 23) is one of two components of the centralspindlin complex assembled during late stages of mitosis. Formation of this complex is known as an essential step for cytokinesis. Here,

Externí odkaz: https://doaj.org/article/666b4b8b77c64e5caf3efef49c229974

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SCAI promotes error-free repair of DNA interstrand crosslinks via the Fanconi anemia pathway

Autor: Lisa Schubert, Ivo A Hendriks, Emil P T Hertz, Wei Wu, Selene Sellés‐Baiget, Saskia Hoffmann, Keerthana Stine Viswalingam, Irene Gallina, Satyakrishna Pentakota, Bente Benedict, Joachim Johansen, Katja Apelt, Martijn S Luijsterburg, Simon Rasmussen, Michael Lisby, Ying Liu, Michael L Nielsen, Niels Mailand, Julien P Duxin

Publikováno v: EMBO Reports, 23(4). WILEY
Schubert, L, Hendriks, I A, Hertz, E P T, Wu, W, Sellés-Baiget, S, Hoffmann, S, Viswalingam, K S, Gallina, I, Pentakota, S, Benedict, B, Johansen, J, Apelt, K, Luijsterburg, M S, Rasmussen, S, Lisby, M, Liu, Y, Nielsen, M L, Mailand, N & Duxin, J P 2022, ' SCAI promotes error-free repair of DNA interstrand crosslinks via the Fanconi anemia pathway ', EMBO Reports, vol. 23, no. 4, e53639 . https://doi.org/10.15252/embr.202153639

DNA interstrand crosslinks (ICLs) are cytotoxic lesions that threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activation step that triggers in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b635fe1b7eb375726bd27f3881f73f4
https://doi.org/10.15252/embr.202153639

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FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease

Autor: Niels Mailand, Marta Gallo, Fabian Coscia, Nicholas M.I. Taylor, Matthias Mann, Peter Haahr, Satyakrishna Pentakota, Andreas Mund, Saskia Hoffmann

Publikováno v: Hoffmann, S, Pentakota, S, Mund, A, Haahr, P, Coscia, F, Gallo, M, Mann, M, Taylor, N M I & Mailand, N 2020, ' FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease ', EMBO Reports, vol. 21, no. 10, e50662 . https://doi.org/10.15252/embr.202050662
EMBO Reports

Dominant missense mutations in the human serine protease FAM111A underlie perinatally lethal gracile bone dysplasia and Kenny–Caffey syndrome, yet how FAM111A mutations lead to disease is not known. We show that FAM111A proteolytic activity suppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b03638cd40615b1ed54997820a49ec
https://curis.ku.dk/ws/files/250485170/embr.202050662.pdf

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Automated quantification of mitral valve tenting volume in functional mitral regurgitation by three��dimensional echocardiography

Autor: Gerd Baldenhofer, Marius Schwerg, Henryk Dreger, Fabian Knebel, Sebastian Kruck, Christian Heupel, Saskia Hoffmann, Karl Stangl, Ruta Jasaityte, Anne Hübscher

Background Tenting of the mitral leaflets is a major pathophysiological factor contributing to functional mitral regurgitation (FMR). A novel software tool allows automated quantification of the tenting volume (TnV) by 3D transesophageal echocardiogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310022d9d6d1ab8792e5d9a607c1f143

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Defining a Cutoff for Progression of Macular Holes

Autor: Navid Johannigmann-Malek, Carmen Baumann, Ahmed Almarzooqi, Saskia Hoffmann, Chris P. Lohmann, Stephen B. Kaye

Publikováno v: Translational Vision Science & Technology
Translational vision science & technology

PurposeThe purpose of this study was to determine a cutoff for progression of idiopathic full-thickness macular hole (MH) size.MethodsRetrospective analysis of consecutive patients waiting 4 weeks for MH surgery. Two observers performed 3 repeat sets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc46bd0998e248c1a8f2cf7743d5585
https://doi.org/10.1167/tvst.10.13.2

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Author response: TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Autor: Rahul Bhowmick, Karim Labib, Remi Sonneville, Ian D. Hickson, Niels Mailand, Saskia Hoffmann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e33416ea5bb8d21527fd3c9a1d8b80a
https://doi.org/10.7554/elife.48686.017

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TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Autor: Karim Labib, Saskia Hoffmann, Niels Mailand, Ian D. Hickson, Rahul Bhowmick, Remi Sonneville

Publikováno v: Sonneville, R, Bhowmick, R, Hoffmann, S, Mailand, N, Hickson, I D & Labib, K 2019, ' TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication ', eLife, vol. 8, e48686 . https://doi.org/10.7554/eLife.48686
eLife, Vol 8 (2019)
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce912e81f5e742651059c802cf3bae4
https://curis.ku.dk/portal/da/publications/traip-drives-replisome-disassembly-and-mitotic-dna-repair-synthesis-at-sites-of-incomplete-dna-replication(4c483784-38b2-417e-8107-c849353a09ce).html

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