Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Saskia C. Stein"'
Publikováno v:
International Journal of Medical Microbiology, Vol 313, Iss 4, Pp 151585- (2023)
Lipopolysaccharide inner core heptose metabolites, including ADP-heptose, play a substantial role in the activation of cell-autonomous innate immune responses in eukaryotic cells, via the ALPK1-TIFA signaling pathway, as demonstrated for various path
Externí odkaz:
https://doaj.org/article/8b8ca4b699b2432289317768dd0dbb28
Autor:
Larissa Faass, Saskia C. Stein, Martina Hauke, Madeleine Gapp, Manuel Albanese, Christine Josenhans
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The human gastric pathogen Helicobacter pylori activates human epithelial cells by a particular combination of mechanisms, including NOD1 and ALPK1-TIFA activation. These mechanisms are characterized by a strong participation of the bacterial cag pat
Externí odkaz:
https://doaj.org/article/ca6309487e974da2bd590bd42ce840fe
Publikováno v:
Current Opinion in Immunology. 82:102301
Autor:
Saskia C Stein, Eugenia Faber, Simon H Bats, Tatiana Murillo, Yvonne Speidel, Nina Coombs, Christine Josenhans
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006514 (2017)
Highly virulent Helicobacter pylori cause proinflammatory signaling inducing the transcriptional activation and secretion of cytokines such as IL-8 in epithelial cells. Responsible in part for this signaling is the cag pathogenicity island (cagPAI) t
Externí odkaz:
https://doaj.org/article/45d4d5c3041a40b99256414cc14e2243
Autor:
Larissa, Faass, Saskia C, Stein, Martina, Hauke, Madeleine, Gapp, Manuel, Albanese, Christine, Josenhans
Publikováno v:
Frontiers in Immunology
The human gastric pathogen Helicobacter pylori activates human epithelial cells by a particular combination of mechanisms, including NOD1 and ALPK1-TIFA activation. These mechanisms are characterized by a strong participation of the bacterial cag pat
Autor:
Mustafa Yilmaz, Isabelle Pink, Christiane Ritter, Christian Schultze-Florey, Saskia C. Stein, Georg M. N. Behrens, Anne Cossmann, Nina Gödecke, Marius M. Hoeper, Jörg Martens, Hannah Kleine-Weber, Reinhold Förster, Stefanie Willenzon, Berislav Bošnjak, Anne Katrin Cordes, Rainer Blasczyk, Stefan Pöhlmann, Markus Hoffmann, Inga Ravens, Günter Bernhardt, Wolfram Puppe, Thomas F. Schulz
Neutralizing antibodies targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) block severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into cells using surface-expressed angiotensin-converting enzyme 2 (ACE2). We dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acd882f53e087de540b080e29abe51c
Autor:
Saskia C. Stein, Valentin Jakob, Martin Empting, Philine Kirsch, Kevin Oberhausen, Thomas F. Schulz, Ivano Cucarro
Publikováno v:
Journal of medicinal chemistry
The latency-associated nuclear antigen (LANA) is required for latent replication and persistence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. It acts via replicating and tethering the virus episome to the host chromatin and exerts
Autor:
Saskia C. Stein, Julia Rinkes, Valentin Jakob, Martin Empting, Philine Kirsch, Thomas F. Schulz, Aylin Berwanger
Publikováno v:
European journal of medicinal chemistry
France
France
The Latency-associated nuclear antigen (LANA) plays a central role for the latent persistence of the Kaposi's Sarcoma Herpesvirus (KSHV) in the human host and helps to establish lifelong infections. Herein, we report our efforts towards hit-to-lead g
Publikováno v:
Journal of Virology. 86:13303-13312
In this study, we examined the capacities of non-antigen-presenting cell types to propagate antiviral signals following infection with recombinant adenovirus or by direct nucleic acid transfection. Three murine cell lines (RAW264.7 macrophages as a p
Autor:
Saskia C. Stein, Erik Falck-Pedersen
Publikováno v:
Journal of Virology. 86:4527-4537
We have used the RAW 264.7 murine macrophage-like cell line as a platform to characterize the recognition and early signaling response to recombinant adenoviral vectors (rAdV). Infection of RAW 264.7 cells triggers an early response (2 to 6 h postinf