Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Saskia C. A. de Jager"'
Autor:
Anjana Singh, Adriaan O. Kraaijeveld, Adelina Curaj, Kanin Wichapong, Linda Hammerich, Saskia C. A. de Jager, Ilze Bot, Sergei P. Atamas, Theo J. C. van Berkel, J. Wouter Jukema, Iain Comerford, Shaun R. McColl, Barend Mees, Johan W. M. Heemskerk, Gerry A. F. Nicolaes, Tilman Hackeng, Elisa Anamaria Liehn, Frank Tacke, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the r
Externí odkaz:
https://doaj.org/article/573017efcc53412a84624e171b71058e
Autor:
Aoife B. Kilgallen, Frederieke van den Akker, Dries A. M. Feyen, Sandra Crnko, Christian J. B. Snijders Blok, Hendrik Gremmels, Bastiaan C. du Pré, Robin Reijers, Pieter A. Doevendans, Saskia C. A. de Jager, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Linda W. van Laake
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Circadian rhythms influence the recruitment of immune cells and the onset of inflammation, which is pivotal in the response to ischemic cardiac injury after a myocardial infarction (MI). The hyperacute immune response that occurs within the first few
Externí odkaz:
https://doaj.org/article/2c8d8f8f5bf5497ca023fd74c4cb118c
Autor:
Patricia van den Hoogen, Manon M. H. Huibers, Floor W. van den Dolder, Roel de Weger, Erica Siera-de Koning, Marish I. F. Oerlemans, Nicolaas de Jonge, Linda W. van Laake, Pieter A. Doevendans, Joost. P. G. Sluijter, Aryan Vink, Saskia C. A. de Jager
Publikováno v:
Biology, Vol 12, Iss 1, p 61 (2022)
Cardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart transplantation (HTx). Interestingly, increased plasma levels of immunoglobulins have been fo
Externí odkaz:
https://doaj.org/article/052311861a394f7db06126baef2e60c0
Autor:
Max J. M. Silvis, Evelyne J. Demkes, Leo Timmers, Fatih Arslan, Saskia C. A. de Jager, Joost P. G. Sluijter, Arend Mosterd, Dominique P. V. de Kleijn, Lena Bosch, Gerardus P. J. van Hout
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3056 (2022)
NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose of this study was to investigate the effects of the NLRP3-inflammasome inhibitor IZD334 on c
Externí odkaz:
https://doaj.org/article/8797b0c53dd94455a8ff3413276c725f
Autor:
Evelyne J. Demkes, Steven Wenker, Max J. M. Silvis, Martijn M. J. van Nieuwburg, M. Joyce Visser, Marlijn S. Jansen, Maike A. D. Brans, Evelyn Velema, Joost P. G. Sluijter, Imo E. Hoefer, Dominique P. V. de Kleijn, Leo Timmers, Saskia C. A. de Jager
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Ischemia-reperfusion and cardiac remodeling is associated with cardiomyocyte death, excessive fibrosis formation, and functional decline, eventually resulting in heart failure (HF). Glucagon-like peptide (GLP)-1 agonists are reported to r
Externí odkaz:
https://doaj.org/article/d792ea9a5a5a406d8a2b3bdf94c0194c
Autor:
Marian Wesseling, Eva Mulder, Maike A. D. Brans, Daniek. M. C. Kapteijn, Marian Bulthuis, Gerard Pasterkamp, Marianne C. Verhaar, A. H. Jan Danser, Harry van Goor, Jaap A. Joles, Saskia C. A. de Jager
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cardiorenal syndrome type 2 is characterized by kidney failure as a consequence of heart failure that affects >50% of heart failure patients. Murine transverse aortic constriction (TAC) is a heart failure model, where pressure overload is induced on
Externí odkaz:
https://doaj.org/article/dde3f13552ef4eaf8a4ce7838f13f152
Autor:
Max J. M. Silvis, Selma E. Kaffka genaamd Dengler, Clémence A. Odille, Mudit Mishra, Niels P. van der Kaaij, Pieter A. Doevendans, Joost P. G. Sluijter, Dominique P. V. de Kleijn, Saskia C. A. de Jager, Lena Bosch, Gerardus P. J. van Hout
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a coronary artery. A similar phenomenon is observed in heart transplanta
Externí odkaz:
https://doaj.org/article/2ad6034569004103aea0b56035843858
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7831 (2021)
After myocardial infarction (MI), a strong inflammatory response takes place in the heart to remove the dead tissue resulting from ischemic injury. A growing body of evidence suggests that timely resolution of this inflammatory process may aid in the
Externí odkaz:
https://doaj.org/article/dce2ddef735a492381012fad0535363d
Autor:
Jiong-Wei Wang, Magda S. C. Fontes, Xiaoyuan Wang, Suet Yen Chong, Elise L. Kessler, Ya-Nan Zhang, Judith J. de Haan, Fatih Arslan, Saskia C. A. de Jager, Leo Timmers, Toon A. B. van Veen, Carolyn S. P. Lam, Dominique P. V. de Kleijn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertro
Externí odkaz:
https://doaj.org/article/d91281989b32469aa064567a69b66e0f
Autor:
Judith J. De Haan, Saskia Haitjema, Hester M. den Ruijter, Gerard Pasterkamp, Gert J. de Borst, Martin Teraa, Marianne C. Verhaar, Hendrik Gremmels, Saskia C. A. de Jager
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 9 (2017)
BackgroundPeripheral artery disease (PAD) is one of the most common clinical presentations of atherosclerosis, and its prevalence is still increasing. Despite improvement of health care, morbidity and mortality risks remain high, including the risk o
Externí odkaz:
https://doaj.org/article/1d09da21bb404898892b9b96522b7ada