Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial

Autor: Saskia C. van der Boor, Manon Alkema, Geert-Jan van Gemert, Karina Teelen, Marga van de Vegte-Bolmer, Jona Walk, Reinout van Crevel, Quirijn de Mast, Christian F. Ockenhouse, Robert W. Sauerwein, Matthew B. B. McCall

Publikováno v: BMC Medicine, Vol 21, Iss 1, Pp 1-14 (2023)

Abstract Background Whole sporozoite immunization under chemoprophylaxis (CPS regime) induces long-lasting sterile homologous protection in the controlled human malaria infection model using Plasmodium falciparum strain NF54. The relative proficiency

Externí odkaz: https://doaj.org/article/28495ce92cd3443cb2435728df4cd2f2

Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults

Autor: Saskia C van der Boor, Merel J Smit, Stijn W van Beek, Jordache Ramjith, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Peter Pickkers, Yimin Wu, Emily Locke, Shwu-Maan Lee, John Aponte, C Richter King, Ashley J Birkett, Kazutoyo Miura, Morolayo A Ayorinde, Robert W Sauerwein, Rob ter Heine, Christian F Ockenhouse, Teun Bousema, Matthijs M Jore, Matthew B B McCall

Publikováno v: Lancet Infectious Diseases, 22, 1596-1605
Lancet Infectious Diseases, 22, 11, pp. 1596-1605

Contains fulltext : 287660.pdf (Publisher’s version ) (Open Access) BACKGROUND: Malaria elimination requires interruption of the highly efficient transmission of Plasmodium parasites by mosquitoes. TB31F is a humanised monoclonal antibody that bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6447ac72a6a077d34ada58b429987eb
https://doi.org/10.1016/s1473-3099(22)00428-5

Modeling the Impact of a Highly Potent Plasmodium falciparum Transmission-Blocking Monoclonal Antibody in Areas of Seasonal Malaria Transmission

Autor: Joseph D Challenger, Stijn W van Beek, Rob ter Heine, Saskia C van der Boor, Giovanni D Charles, Merel J Smit, Chris Ockenhouse, John J Aponte, Matthew B B McCall, Matthijs M Jore, Thomas S Churcher, Teun Bousema

Publikováno v: The Journal of Infectious Diseases.

Transmission-blocking interventions can play an important role in combating malaria worldwide. Recently, a highly potent Plasmodium falciparum transmission-blocking monoclonal antibody (TB31F) was demonstrated to be safe and efficacious in malaria-na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3895e04b62bb3191e6f15eb5bbe3c60d
https://doi.org/10.1093/infdis/jiad101

Safety, Tolerability and Plasmodium Falciparum Transmission-Reducing Activity of Monoclonal Antibody TB31F: An Open-Label, First-in-Human, Trial in Healthy Malaria-Naïve Adults

Autor: Saskia C. van der Boor, Merel Smit, Stijn W. van Beek, Jordache Ramjith, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Peter Pickkers, Yimin Wu, Emily Locke, Shwu-Maan Lee, C. Richter King, Ashley J. Birkett, Kazutoyo Miura, Morolayo A. Ayorinde, Robert W. Sauerwein, Rob ter Heine, Christian F. Ockenhouse, Teun Bousema, Matthijs M. Jore, Matthew McCall

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0d0b02e940eacb58f5fc63d1516f381
https://doi.org/10.2139/ssrn.4054462

A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1

Autor: Marga van de Vegte-Bolmer, Peter F. Billingsley, Marie-Astrid Hoogerwerf, Jan Pieter R. Koopman, X. Zen Yap, Stephen L. Hoffman, Chris J. Janse, Mikhael D Manurung, Shahid M. Khan, Robert W. Sauerwein, Tom L. Richie, Meta Roestenberg, Jacqueline J. Janse, André J. A. M. van der Ven, Leo G. Visser, Quirijn de Mast, Jona Walk, B. Kim Lee Sim, Amanda Fabra García, Youri M van Waardenburg, Karina Teelen, Saskia C. van der Boor, Yonas Abebe, Geert-Jan van Gemert, Natasha Kc, Tooba Murshedkar, Marijke C. C. Langenberg, Pauline Meij, Els Wessels

Publikováno v: Science Translational Medicine, 12, 544
Science Translational Medicine, 12
Science Translational Medicine, 12(544). AMER ASSOC ADVANCEMENT SCIENCE

Immunization with attenuated Plasmodium sporozoites can induce protection against malaria infection, as shown by Plasmodium fakiparum (Pf) sporozoites attenuated by radiation in multiple clinical trials. As alternative attenuation strategy with a mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c34498845ec1855fcc498a358c2318b
https://hdl.handle.net/2066/219578