Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Saskia B Neher"'
Autor:
Robert Risti, Kathryn H Gunn, Kristofer Hiis-Hommuk, Natjan-Naatan Seeba, Hamed Karimi, Ly Villo, Marko Vendelin, Saskia B Neher, Aivar Lõokene
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283358 (2023)
Lipoprotein lipase (LPL), a crucial enzyme in the intravascular hydrolysis of triglyceride-rich lipoproteins, is a potential drug target for the treatment of hypertriglyceridemia. The activity and stability of LPL are influenced by a complex ligand n
Externí odkaz:
https://doaj.org/article/471c224a265c4d6c8a964152aa0edf8f
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135447 (2015)
Mycobacterium tuberculosis harbors over 160 genes encoding PE/PPE proteins, several of which have roles in the pathogen's virulence. A number of PE/PPE proteins are secreted via Type VII secretion systems known as the ESX secretion systems. One PE pr
Externí odkaz:
https://doaj.org/article/9ef0013cda7144d49e32575daab18155
Autor:
Ming Jing Wu, Anna Wolska, Benjamin S. Roberts, Ellis M. Pearson, Aspen R. Gutgsell, Alan T. Remaley, Saskia B. Neher
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2456-2465 (2018)
LPL is a secreted enzyme that hydrolyzes triglycerides from circulating lipoproteins. Individuals lacking LPL suffer from severe hypertriglyceridemia, a risk factor for acute pancreatitis. One potential treatment is to administer recombinant LPL as a
Externí odkaz:
https://doaj.org/article/c4ed15e75e3a431ba9946ec87c0c8a82
Autor:
Kathryn H. Gunn, Saskia B. Neher
Publikováno v:
Nature Communications. 14
Lipoprotein lipase (LPL) hydrolyzes triglycerides from circulating lipoproteins, releasing free fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for cardiovascular disease (CVD). Using cryogenic electron micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::686994e1f4d427a3a073e03159098ca0
https://doi.org/10.1038/s41467-023-38243-9
https://doi.org/10.1038/s41467-023-38243-9
Autor:
Kathryn H. Gunn, Saskia B. Neher
Publikováno v:
bioRxiv
Lipoprotein lipase (LPL) hydrolyzes triglycerides from circulating lipoproteins, releasing free fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for cardiovascular disease (CVD). Using cryogenic electron micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f860590e2074f5d46d66a9f409fc137
https://doi.org/10.1101/2023.03.21.533650
https://doi.org/10.1101/2023.03.21.533650
Publikováno v:
J Cell Sci
Lipoprotein lipase (LPL) is a secreted triglyceride lipase involved in the clearance of very-low-density lipoproteins and chylomicrons from circulation. LPL is expressed primarily in adipose and muscle tissues and transported to the capillary lumen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd04bf9776d09ace2203f3951e69df96
https://doi.org/10.1242/jcs.258734
https://doi.org/10.1242/jcs.258734
Autor:
Aakash Mehta, Kathryn H. Gunn, Samantha S. Stadmiller, Gary J. Pielak, Samantha Piszkiewicz, Thomas C. Boothby, Elizabeth Kuhlman, Kenny H. Nguyen, Alex J. Guseman, Owen Warmuth, Saskia B. Neher, Ashlee M. Propst
Publikováno v:
Protein Sci
Protein-based biological drugs and many industrial enzymes are unstable, making them prohibitively expensive. Some can be stabilized by formulation with excipients, but most still require low temperature storage. In search of new, more robust excipie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694d88808312fe84a62add0260b6b5d7
https://doi.org/10.1002/pro.3604
https://doi.org/10.1002/pro.3604
Autor:
Ellis M. Pearson, Ming Jing Wu, Aspen R. Gutgsell, Alan T. Remaley, Anna Wolska, Saskia B. Neher, Benjamin S. Roberts
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2456-2465 (2018)
LPL is a secreted enzyme that hydrolyzes triglycerides from circulating lipoproteins. Individuals lacking LPL suffer from severe hypertriglyceridemia, a risk factor for acute pancreatitis. One potential treatment is to administer recombinant LPL as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2461a2a84a14e910a46f88804dde29bf
https://doi.org/10.1194/jlr.d086793
https://doi.org/10.1194/jlr.d086793
Autor:
Mario J. Borgnia, Edward H. Egelman, Fengbin Wang, Benjamin S. Roberts, Saskia B. Neher, Joshua D. Strauss, Kathryn H. Gunn
Publikováno v:
Proc Natl Acad Sci U S A
Lipases are enzymes necessary for the proper distribution and utilization of lipids in the human body. Lipoprotein lipase (LPL) is active in capillaries, where it plays a crucial role in preventing dyslipidemia by hydrolyzing triglycerides from packa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586eb6c51e2693213f3a118dc66b58d4
https://pubmed.ncbi.nlm.nih.gov/32332168
https://pubmed.ncbi.nlm.nih.gov/32332168
Publikováno v:
Biochemistry. 56:525-533
Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipoproteins. Whereas most identified mutations in the LPL gene are deleterious, one mutation, LPLS447X, causes a gain of function. This mutation truncates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a6052f19c12e3fac1eefaae2e246d2
https://doi.org/10.1021/acs.biochem.6b00945
https://doi.org/10.1021/acs.biochem.6b00945