Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Sasirekha Ramani"'
Autor:
Grace O. Adeniyi-Ipadeola, Julia D. Hankins, Amal Kambal, Xi-Lei Zeng, Ketki Patil, Victoria Poplaski, Carolyn Bomidi, Hoa Nguyen-Phuc, Sandra L. Grimm, Cristian Coarfa, Fabio Stossi, Sue E. Crawford, Sarah E. Blutt, Allison L. Speer, Mary K. Estes, Sasirekha Ramani
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Human intestinal enteroids (HIEs) are gaining recognition as physiologically relevant models of the intestinal epithelium. While HIEs from adults are used extensively in biomedical research, few studies have used HIEs from infants. Consideri
Externí odkaz:
https://doaj.org/article/21fddf0cda974e5890184c60894d739a
Autor:
Evelien Kramer, Ketki Patil, Vassilis Triantis, Jan A. H. Bastiaans, Michela Mazzon, Sasirekha Ramani, Tim T. Lambers
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
BackgroundAmong the most common mucosal viral infections in infants are rotavirus, one of the main causes of severe gastroenteritis in infants and children up to 5 years, and respiratory syncytial virus (RSV), one of the leading causes of lower respi
Externí odkaz:
https://doaj.org/article/a0a3d8ad7d2a4b70be07c0d15fa44e0f
Autor:
Adam P. Wilson, Karni S. Moshal, Addison P. Franca, Sasirekha Ramani, Randle Gallucci, Hala Chaaban, Kathryn Y. Burge
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103082- (2024)
Summary: Enteroids are in vitro models to study gastrointestinal pathologies and test personalized therapeutics; however, the inherent complexity of enteroids often renders standard gene editing approaches ineffective. Here, we introduce a refined le
Externí odkaz:
https://doaj.org/article/59c630c92381413f88a5dd2ff4997203
Autor:
Vu L. Ngo, Yanling Wang, Yadong Wang, Zhenda Shi, Robert Britton, Jun Zou, Sasirekha Ramani, Baoming Jiang, Andrew T. Gewirtz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 5, Pp 101393- (2024)
Background & Aims: The protection provided by rotavirus (RV) vaccines is highly heterogeneous among individuals. We hypothesized that microbiota composition might influence RV vaccine efficacy. Methods: First, we examined the potential of segmented f
Externí odkaz:
https://doaj.org/article/46652c5e97f34f33b56e6facf57a1b1d
Autor:
Fengju Chen, Yiqun Zhang, Richard Sucgang, Sasirekha Ramani, David Corry, Farrah Kheradmand, Chad J. Creighton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined tran
Externí odkaz:
https://doaj.org/article/9b32e15347954632ac38e333b12d3c55
Autor:
Sidhartha Giri, C. P. Girish Kumar, Shainey Alokit Khakha, Mamta Chawla-Sarkar, Varanasi Gopalkrishna, Shobha D. Chitambar, Pratima Ray, S. Venkatasubramanian, Biswa Jyoti Borkakoty, Subarna Roy, Jyothi Bhat, Bhagirathi Dwibedi, Pradeep Das, Vijayachari Paluru, Sasirekha Ramani, Sudhir Babji, Rashmi Arora, Sanjay M. Mehendale, Mohan D. Gupte, Gagandeep Kang, National Rotavirus Surveillance Network investigators
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background From 2016, the Government of India introduced the oral rotavirus vaccine into the national immunization schedule. Currently, two indigenously developed vaccines (ROTAVAC, Bharat Biotech; ROTASIIL, Serum Institute of India) are inc
Externí odkaz:
https://doaj.org/article/361cc55827974227acbad73e5ea0f5de
Autor:
Khalil Ettayebi, Victoria R. Tenge, Nicolas W. Cortes-Penfield, Sue E. Crawford, Frederick H. Neill, Xi-Lei Zeng, Xiaomin Yu, B. Vijayalakshmi Ayyar, Douglas Burrin, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Human noroviruses (HuNoVs) are highly contagious and cause acute and sporadic diarrheal illness in all age groups. In addition, chronic infections occur in immunocompromised cancer and transplant patients.
Externí odkaz:
https://doaj.org/article/b177e281ff684ac1932fbdc28be0274c
Autor:
Kei Haga, Khalil Ettayebi, Victoria R. Tenge, Umesh C. Karandikar, Miranda A. Lewis, Shih-Ching Lin, Frederick H. Neill, B. Vijayalakshmi Ayyar, Xi-Lei Zeng, Göran Larson, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis worldwide. Histo-blood group antigen (HBGA) expression is an important susceptibility factor for HuNoV infection based on controlled human infection models and
Externí odkaz:
https://doaj.org/article/c7d23fae05e64407a2dfc2249cda3572
Autor:
Sasirekha Ramani, Christopher J. Stewart, Daniel R. Laucirica, Nadim J. Ajami, Bianca Robertson, Chloe A. Autran, Dhairyasheel Shinge, Sandya Rani, Sasirekha Anandan, Liya Hu, Josephine C. Ferreon, Kurien A. Kuruvilla, Joseph F. Petrosino, B. V. Venkataram Prasad, Lars Bode, Gagandeep Kang, Mary K. Estes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Neonatal rotavirus infections are associated with gastrointestinal symptoms in some settings, but the role of host factors in clinical presentation is unclear. Here, Ramani et al. show that human milk oligosaccharides and microbiome are associated wi
Externí odkaz:
https://doaj.org/article/f78defa712ee45d3809a0e52edeacecb
Autor:
Liya Hu, Banumathi Sankaran, Daniel R. Laucirica, Ketki Patil, Wilhelm Salmen, Allan Chris M Ferreon, Phoebe S. Tsoi, Yi Lasanajak, David F. Smith, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Josephine C. Ferreon, B. V. Venkataram Prasad
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HB
Externí odkaz:
https://doaj.org/article/226e37b8d4144a7d953870719068de7d