Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Sasinya N. Scott"'
Autor:
Barry S. Taylor, David B. Solit, John H.J. Petrini, Michael F. Berger, Dean F. Bajorin, Jonathan E. Rosenberg, Bernard H. Bochner, Victor Reuter, Gary K. Schwartz, Agnes Viale, Nicholas D. Socci, Philip Kim, Irina Ostrovnaya, Mono Pirun, Gregory C. McDermott, A. Rose Brannon, Sasinya N. Scott, Aphrothiti J. Hanrahan, Nikolaus Schultz, Akiko Inagaki, Saurabh Asthana, Marcel Hohl, Gopa Iyer, Hikmat Al-Ahmadie
PDF file - 470KB, All supplementary figures including tumor histology, RAD50 immunohistochemistry, candidate mutations and their clonality, and supporting yeast and MEF experimental data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004caeb931f614011c4bbcb743556aa1
https://doi.org/10.1158/2159-8290.22531730
https://doi.org/10.1158/2159-8290.22531730
Autor:
Barry S. Taylor, David B. Solit, John H.J. Petrini, Michael F. Berger, Dean F. Bajorin, Jonathan E. Rosenberg, Bernard H. Bochner, Victor Reuter, Gary K. Schwartz, Agnes Viale, Nicholas D. Socci, Philip Kim, Irina Ostrovnaya, Mono Pirun, Gregory C. McDermott, A. Rose Brannon, Sasinya N. Scott, Aphrothiti J. Hanrahan, Nikolaus Schultz, Akiko Inagaki, Saurabh Asthana, Marcel Hohl, Gopa Iyer, Hikmat Al-Ahmadie
PDF file - 2461KB, A complete listing of somatic mutations and rearrangements detected as well as targeted genes, sequences, MRN complex mutation frequency, and strains utilized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9db9d6667a66f9467dc0918b03374c
https://doi.org/10.1158/2159-8290.22531724.v1
https://doi.org/10.1158/2159-8290.22531724.v1
Autor:
Barry S. Taylor, David B. Solit, John H.J. Petrini, Michael F. Berger, Dean F. Bajorin, Jonathan E. Rosenberg, Bernard H. Bochner, Victor Reuter, Gary K. Schwartz, Agnes Viale, Nicholas D. Socci, Philip Kim, Irina Ostrovnaya, Mono Pirun, Gregory C. McDermott, A. Rose Brannon, Sasinya N. Scott, Aphrothiti J. Hanrahan, Nikolaus Schultz, Akiko Inagaki, Saurabh Asthana, Marcel Hohl, Gopa Iyer, Hikmat Al-Ahmadie
PDF file - 321KB, A detailed description of additional methods utilized (and associated references) for sequencing and analysis as well as an explanatory note regarding the TM pathway in yeast.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc3f6d8eb179fa32d22c930c56d78b8
https://doi.org/10.1158/2159-8290.22531727.v1
https://doi.org/10.1158/2159-8290.22531727.v1
Autor:
James J. Hsieh, Michael F. Berger, Robert J. Motzer, Emily H. Cheng, Paul Russo, Victor E. Reuter, Chris Sander, Nikolaus Schultz, Agnes Viale, Nicholas D. Socci, Sasinya N. Scott, Shugaku Takeda, Han Liu, Oguz Akin, Luis F. Cunha, Ying-Bei Chen, A. Rose Brannon, Can G. Pham, A. Ari Hakimi, Martin H. Voss
PDF file - 3248K, Supplementary Table S1. Histopathologic findings for multi-region analysis. Supplementary Table S2.IMPACT gene list and their respective chromosomal positions. Supplementary Table S5. WEC run statistics on patients #4 and #5. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec2558473a5a787fb3d82c5110f389d
https://doi.org/10.1158/1078-0432.22450620.v1
https://doi.org/10.1158/1078-0432.22450620.v1
Autor:
Paul B. Chapman, Neal Rosen, Gary K. Schwartz, Richard D. Carvajal, Jedd D. Wolchok, Katherine S. Panageas, Mario E. Lacouture, Tunc Iyriboz, Sasinya N. Scott, Michael F. Berger, Melissa P. Pulitzer, David B. Solit, Federica Catalanotti
PDF file - 48K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0439452160401120bfc29e868fccfbb9
https://doi.org/10.1158/1078-0432.22451649
https://doi.org/10.1158/1078-0432.22451649
Autor:
James J. Hsieh, Michael F. Berger, Robert J. Motzer, Emily H. Cheng, Paul Russo, Victor E. Reuter, Chris Sander, Nikolaus Schultz, Agnes Viale, Nicholas D. Socci, Sasinya N. Scott, Shugaku Takeda, Han Liu, Oguz Akin, Luis F. Cunha, Ying-Bei Chen, A. Rose Brannon, Can G. Pham, A. Ari Hakimi, Martin H. Voss
Purpose: Rapalogs are allosteric mTOR inhibitors and approved agents for advanced kidney cancer. Reports of clonal heterogeneity in this disease challenge the concept of targeted monotherapy, yet a small subset of patients derives extended benefit. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70926451ddabaf09c091c540c3ac73b4
https://doi.org/10.1158/1078-0432.c.6521976.v1
https://doi.org/10.1158/1078-0432.c.6521976.v1
Autor:
Paul B. Chapman, Neal Rosen, Gary K. Schwartz, Richard D. Carvajal, Jedd D. Wolchok, Katherine S. Panageas, Mario E. Lacouture, Tunc Iyriboz, Sasinya N. Scott, Michael F. Berger, Melissa P. Pulitzer, David B. Solit, Federica Catalanotti
PDF file - 2798K, Immunohistochemical (IHC) staining of high pAKT tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a31c1dbdba4f5d483d5762dba85a41
https://doi.org/10.1158/1078-0432.22451664.v1
https://doi.org/10.1158/1078-0432.22451664.v1
Autor:
Paul B. Chapman, Neal Rosen, Gary K. Schwartz, Richard D. Carvajal, Jedd D. Wolchok, Katherine S. Panageas, Mario E. Lacouture, Tunc Iyriboz, Sasinya N. Scott, Michael F. Berger, Melissa P. Pulitzer, David B. Solit, Federica Catalanotti
Purpose: Test the hypothesis that in BRAF-mutated melanomas, clinical responses to selumetinib, a MEK inhibitor, will be restricted to tumors in which the PI3K/AKT pathway is not activated.Experimental Design: We conducted a phase II trial in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695647c837013ba9164882ed81b235e8
https://doi.org/10.1158/1078-0432.c.6522243
https://doi.org/10.1158/1078-0432.c.6522243
Autor:
Paul B. Chapman, Neal Rosen, Gary K. Schwartz, Richard D. Carvajal, Jedd D. Wolchok, Katherine S. Panageas, Mario E. Lacouture, Tunc Iyriboz, Sasinya N. Scott, Michael F. Berger, Melissa P. Pulitzer, David B. Solit, Federica Catalanotti
PDF file - 6545K, Detection of a K57N MEK1 mutation in DNA from formalin-fixed paraffin-embedded tumor and matched normal tissue from one patient. Multiple reads from tumor-derived DNA (panel on left) show a GC transversion in 21% of reads. This i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8ecdd197e02d2a1554634f4f2f4afb
https://doi.org/10.1158/1078-0432.22451652
https://doi.org/10.1158/1078-0432.22451652
Autor:
James J. Hsieh, Michael F. Berger, Robert J. Motzer, Emily H. Cheng, Paul Russo, Victor E. Reuter, Chris Sander, Nikolaus Schultz, Agnes Viale, Nicholas D. Socci, Sasinya N. Scott, Shugaku Takeda, Han Liu, Oguz Akin, Luis F. Cunha, Ying-Bei Chen, A. Rose Brannon, Can G. Pham, A. Ari Hakimi, Martin H. Voss
XLSX file - 13K, Supplementary Table S3. Impact assay run statistics on all samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe01646fb892f91c3601e0adca26ae9
https://doi.org/10.1158/1078-0432.22450614.v1
https://doi.org/10.1158/1078-0432.22450614.v1