Výsledky vyhledávání - "Sashidhar R. Yerram"

GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer

Autor: Sashidhar R. Yerram, Breann Yanagisawa, Nina Chu, Todd D. Armstrong, Ludmila Danilova, Manuel Hidalgo, Lorraine Pelosof, Nilofer S. Azad, James G. Herman

Publikováno v: Epigenetics. 12:540-550

Epigenetic control of gene expression is a major determinant of tumor phenotype and has been found to influence sensitivity to individual chemotherapeutic agents. Glutathione peroxidase 3 (GPX3, plasma glutathione peroxidase) is a key component of ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf008dbe5cf50d45a0e09f6825f422c0
https://doi.org/10.1080/15592294.2016.1265711

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Hypersensitivities for Acetaldehyde and Other Agents among Cancer Cells Null for Clinically Relevant Fanconi Anemia Genes

Autor: M. Zulfiquer Hossain, Scott E. Kern, Surojit Sur, Carlo Rago, Soma Ghosh, Yunzhao R. Ren, Bogdan C. Paun, Sashidhar R. Yerram, Nilofer A. Azad, Anil K. Bhunia, Christine A. Iacobuzio-Donahue

Publikováno v: The American Journal of Pathology. 184(1):260-270

Large-magnitude numerical distinctions (>10-fold) among drug responses of genetically contrasting cancers were crucial for guiding the development of some targeted therapies. Similar strategies brought epidemiological clues and prevention goals for g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f456a8668562bd335902e72e65170191

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DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells

Autor: James G. Herman, Calvin Lee, Sashidhar R. Yerram, Megan A. Healey, Nilofer S. Azad, Kalpesh Patel, M. Zulfiquer Hossain, Scott E. Kern, Weijie Poh

Publikováno v: Oncotarget

// M. Zulfiquer Hossain 1 , Megan A. Healey 1 , Calvin Lee 1 , Weijie Poh 1 , Sashidhar R. Yerram 1 , Kalpesh Patel 1 , Nilofer S. Azad 1 , James G. Herman 1 , and Scott E. Kern 1 1 Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7a1923dec3d9437bfc06a265e124a0
https://doi.org/10.18632/oncotarget.863

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Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells

Autor: Nilofer S. Azad, Rajita Vatapalli, Nita Ahuja, Cynthia A. Zahnow, Stephen B. Baylin, Jasvinder Singh, Sashidhar R. Yerram, Anup Sharma, Eihab Abdelfatah, Angela A. Guzzetta, K. Wyatt McMahon, Yue Hu, Zachary Kerner

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0176139 (2017)

Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. In the metastatic setting, the majority of patients respond to initial therapies but eventually develop resistance and progress. In this study, we test the hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbf178a55f51704d69645c250535f0a
https://doi.org/10.1371/journal.pone.0176139

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A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing

Autor: Scott E. Kern, Kalpesh Patel, Sashidhar R. Yerram, Nilofer A. Azad

Publikováno v: Oncotarget

5-Fluorouracil (5FU) and similar fluoropyrimidines induce covalent modification of thymidylate synthase (TS) and inhibit its activity. They are often used to treat solid cancers, but drug resistance and toxicity are drawbacks. Therefore, there is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efce3e3d75c417daf8fc2c6813d4f66
https://pubmed.ncbi.nlm.nih.gov/22824673

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GPX3 as a predictive biomarker in gastrointestinal malignancies

Autor: James G. Herman, Lorraine Pelosof, Nilofer S. Azad, Sashidhar R. Yerram, Breann Yanagisawa

Publikováno v: Journal of Clinical Oncology. 32:499-499

499 Background: Epigenetic heterogeneity within colorectal and pancreatic tumors influences their sensitivity to individual chemotherapy agents. Glutathione peroxidase 3 (GPX3), part of the cellular antioxidant system, is associated with platinum res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28b562b96c11a8bcbf3a250e4239bb06
https://doi.org/10.1200/jco.2014.32.3_suppl.499

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Abstract 652: GPX3 promoter hypermethylation predicts platinum sensitivity in colorectal cancer cells

Autor: James G. Herman, Lorraine Pelosof, Sashidhar R. Yerram, Nilofer S. Azad

Publikováno v: Cancer Research. 73:652-652

An estimated 52,000 people will die from colorectal cancer (CRC) in 2012 in the U.S. Unfortunately, these tumors do not respond uniformly to the available chemotherapeutic agents and molecular heterogeneity in these tumors is an important factor in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3526f9880b68d4391d6cc22eb265878
https://doi.org/10.1158/1538-7445.am2013-652

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Abstract LB-353: Development of thymidylate synthase ternary complex-specific antibody: A new way to tailor 5-fluorouracil dosing

Autor: Scott E. Kern, Sashidhar R. Yerram, Kalpesh Patel

Publikováno v: Cancer Research. 72:LB-353

Introduction: 5-Fluorouracil (5FU) is a fluorinated nucleoside analogue used in cancer treatment. 5FU metabolites modify thymidylate synthase (TS) to form a ternary complex and inhibit its activity. Despite its benefits, major side effects are common

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24fb017b95b1296deea1d1c9cf309cec
https://doi.org/10.1158/1538-7445.am2012-lb-353

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