Enzymatic N-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases

Autor: Godwin A. Aleku, Gabriel R. Titchiner, George W. Roberts, Sasha R. Derrington, James R. Marshall, Florian Hollfelder, Nicholas J. Turner, David Leys

Allylic amines are a versatile class of synthetic precursors of many valuable nitrogen-containing organic compounds, including pharmaceuticals. Enzymatic allylic amination methods provide a sustainable route to these compounds but are often restricte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d724a5ee32d9b29a5cb707469a0266a

Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass

Autor: Fabio Parmeggiani, James L. Galman, Nicholas J. Turner, Fabio M. Squina, Neil Dixon, Robson Tramontina, Timothy D. H. Bugg, Sasha R. Derrington

Publikováno v: Tramontina, R, Galman, J, Parmeggiani, F, Derrington, S, Bugg, T, Turner, N, Squina, F M & Dixon, N 2019, ' Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass ', Green Chemistry, vol. 22, no. 1, pp. 144-152 . https://doi.org/10.1039/C9GC02359C

Sustainable production of fine chemicals and biofuels from renewable biomass offers a potential alternative to the continued use of finite geological oil reserves. However, in order to compete with current petrochemical refinery processes, alternativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1441f4cc5aa286781f2cee0e5cd558c
https://doi.org/10.1039/c9gc02359c

Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

Autor: Jeremy I. Ramsden, Juan Mangas-Sanchez, Sarah L. Montgomery, Sasha R. Derrington, Rachel S. Heath, Nicholas J. Turner, Keith R. Mulholland

Publikováno v: Journal of the American Chemical Society
Ramsden, J I, Heath, R S, Derrington, S R, Montgomery, S L, Mangas-Sanchez, J, Mulholland, K R & Turner, N J 2019, ' Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades ', Journal of the American Chemical Society . https://doi.org/10.1021/jacs.8b11561

The alkylation of amines with either alcohols or carboxylic acids represents a mild and safe alternative to the use of genotoxic alkyl halides and sulfonate esters. Here we report two complementary one-pot systems in which the reductive aminase (RedA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d2d9962abdc69b1cc0aea41cc70d4d
https://doi.org/10.1021/jacs.8b11561

Enzymatic C-H activation of aromatic compounds through CO

Autor: Godwin A, Aleku, Annica, Saaret, Ruth T, Bradshaw-Allen, Sasha R, Derrington, Gabriel R, Titchiner, Irina, Gostimskaya, Deepankar, Gahloth, David A, Parker, Sam, Hay, David, Leys

Publikováno v: Nature chemical biology. 16(11)

The direct C-H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step in anaerobic microbial degradation of recalcitran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79f836bfc8ca83acdbca69e2a4ae567d
https://pubmed.ncbi.nlm.nih.gov/32719558

A biocatalytic cascade for the conversion of fatty acids to fatty amines

Autor: Han Bevinakatti, Nicholas J. Turner, James L. Galman, Sasha R. Derrington, Joan Citoler

Publikováno v: Green Chemistry

Fatty amine synthesis from renewable sources is an energetically-demanding process involving toxic metal catalysts and harsh reaction conditions as well as selectivity problems. Herein we present a mild, biocatalytic alternative to the conventional a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeed269409b9c3c4ce16c0ec4f4e1ab5