Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Sasha F. Levy"'
Autor:
Joseph J. Hale, Takeshi Matsui, Ilan Goldstein, Martin N. Mullis, Kevin R. Roy, Christopher Ne Ville, Darach Miller, Charley Wang, Trevor Reynolds, Lars M. Steinmetz, Sasha F. Levy, Ian M. Ehrenreich
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Interactions between genetic perturbations and segregating loci can cause perturbations to show different phenotypic effects across genetically distinct individuals. To study these interactions on a genome scale in many individuals, we used
Externí odkaz:
https://doaj.org/article/ee32dc78706e4b53b16fa9b04f944fc0
Autor:
Takeshi Matsui, Martin N. Mullis, Kevin R. Roy, Joseph J. Hale, Rachel Schell, Sasha F. Levy, Ian M. Ehrenreich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Heritable traits can be affected by additive, dominance, and epistatic effects at genetic loci. Here, the authors use chromosomally-encoded barcodes to perform linkage mapping in diploid cross progeny in budding yeast, finding that epistasis in diplo
Externí odkaz:
https://doaj.org/article/ca6975fed8d444fda721b8c44e6948c6
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Protein-protein interactions (PPIs) play a major role in defining biological functions. Here, the authors present PPiSeq, a method to quantitatively score dynamic PPIs in yeast combining fragment complementation assays, genomic double-barcoding, and
Externí odkaz:
https://doaj.org/article/a2d1f7e3c1634cb29a0d1f9355ce7b11
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 1, Pp 143-153 (2017)
Systematic screens for genetic interactions are a cornerstone of both network and systems biology. However, most screens have been limited to characterizing interaction networks in a single environment. Moving beyond this static view of the cell requ
Externí odkaz:
https://doaj.org/article/4ff92dad4c8c4aa98976c6b2e4311313
Autor:
Joseph J. Hale, Takeshi Matsui, Ilan Goldstein, Martin N. Mullis, Kevin R. Roy, Chris Ne Ville, Darach Miller, Charley Wang, Trevor Reynolds, Lars M. Steinmetz, Sasha F. Levy, Ian M. Ehrenreich
Interactions between genetic perturbations and segregating loci can cause perturbations to show different phenotypic effects across genetically distinct individuals. To study these interactions on a genome scale in many individuals, we used combinato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2be24b759f3df9698e0a618f9caa6e1
https://doi.org/10.1101/2023.05.06.539663
https://doi.org/10.1101/2023.05.06.539663
Autor:
Drew S. Tack, Peter D. Tonner, Abe Pressman, Nathanael D. Olson, Sasha F Levy, Eugenia F. Romantseva, Nina Alperovich, Olga Vasilyeva, David Ross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99da06b664ff2f76fdbe5d7669feec12
https://doi.org/10.15252/rc.2022372200
https://doi.org/10.15252/rc.2022372200
Autor:
Martin N Mullis, Caleb Ghione, Michael Lough-Stevens, Ilan Goldstein, Takeshi Matsui, Sasha F Levy, Matthew D Dean, Ian M Ehrenreich
Publikováno v:
Genetics. 222(3)
Determining how genetic polymorphisms enable certain fungi to persist in mammalian hosts can improve understanding of opportunistic fungal pathogenesis, a source of substantial human morbidity and mortality. We examined the genetic basis of fungal pe
Autor:
Drew S. Tack, Peter D. Tonner, Abe Pressman, Nathanael D. Olson, Sasha F. Levy, Eugenia F. Romantseva, Nina Alperovich, Olga Vasilyeva, David Ross
As synthetic biology expands and accelerates into real-world applications, methods for quantitatively and precisely engineering biological function become increasingly relevant. This is particularly true for applications that require programmed sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407c98e6f4f2bfbc100df8b0edb61f7a
https://doi.org/10.1101/2022.08.04.502789
https://doi.org/10.1101/2022.08.04.502789
Publikováno v:
Genetics
Identification of adaptive targets in experimental evolution typically relies on extensive replication and genetic reconstruction. An alternative approach is to directly assay all mutations in an evolved clone by generating pools of segregants that c
Autor:
Xianan Liu, Katherine R. Lawrence, José I. Rojas Echenique, Michael M. Desai, Ivana Cvijovic, Artur Rego-Costa, Sasha F. Levy, Alex N. Nguyen Ba
Publikováno v:
Nature
In rapidly adapting asexual populations, including many microbial pathogens and viruses, numerous mutant lineages often compete for dominance within the population1–5. These complex evolutionary dynamics determine the outcomes of adaptation, but ha