Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sasha A Langley"'
Publikováno v:
eLife, Vol 8 (2019)
Despite critical roles in chromosome segregation and disease, the repetitive structure and vast size of centromeres and their surrounding heterochromatic regions impede studies of genomic variation. Here we report the identification of large-scale ha
Externí odkaz:
https://doaj.org/article/b8eb550abe884c05b81e9f66ddecbf70
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004457 (2014)
An estimated 80% of genomic DNA in eukaryotes is packaged as nucleosomes, which, together with the remaining interstitial linker regions, generate higher order chromatin structures [1]. Nucleosome sequences isolated from diverse organisms exhibit ∼
Externí odkaz:
https://doaj.org/article/5a6568d4963642f39f3a0dad4aae0699
Autor:
James B. Brown, Sasha A. Langley, Antoine M. Snijders, Kenneth H. Wan, Siti Nur Sarah Morris, Benjamin W. Booth, William W. Fisher, Ann S. Hammonds, Soo Park, Richard Weiszmann, Charles Yu, Jennifer A. Kirwan, Ralf J. M. Weber, Mark R. Viant, Jian-Hua Mao, Susan E. Celniker
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Brown et al. apply integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. They find that Acetobacter tropicalis in gnotobiotic animals, is sufficient to rescue incr
Externí odkaz:
https://doaj.org/article/c3ab3d12ed36490693a2a628de744736
Autor:
Young-Mo Kim, Janet K. Jansson, Dehong Hu, Yan-Xia Zhou, B. Y. Loulou Peisl, Thomas O. Metz, Galya Orr, David W. Threadgill, Sarah J. Fansler, Susan E. Celniker, Antoine M. Snijders, Sasha A. Langley, Jian-Hua Mao, Yunshan Wang, Paul Wilmes, Hang Chang, Chenhan Zhong, Colin J. Brislawn
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-14 (2020)
Microbiome
Microbiome, vol 8, iss 1
Microbiome
Microbiome, vol 8, iss 1
Background Recent evidence has linked the gut microbiome to host behavior via the gut–brain axis [1–3]; however, the underlying mechanisms remain unexplored. Here, we determined the links between host genetics, the gut microbiome and memory using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937db1cfab7ffbc10026683227517ac9
http://link.springer.com/article/10.1186/s40168-020-00817-w
http://link.springer.com/article/10.1186/s40168-020-00817-w
Autor:
Jian-Hua Mao, Siti Nur Sarah Morris, Susan E. Celniker, James B. Brown, William W. Fisher, Kenneth H. Wan, Richard Weiszmann, Mark R. Viant, Benjamin W. Booth, Charles Yu, Soo Park, Ann S. Hammonds, Jennifer A. Kirwan, Sasha A. Langley, Antoine M. Snijders, Ralf J. M. Weber
Publikováno v:
Communications biology, vol 4, iss 1
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
The gut microbiome produces vitamins, nutrients, and neurotransmitters, and helps to modulate the host immune system—and also plays a major role in the metabolism of many exogenous compounds, including drugs and chemical toxicants. However, the ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1ffdcd0acbb5a2b1dcf15bed1102fc
https://escholarship.org/uc/item/15g832nr
https://escholarship.org/uc/item/15g832nr
Autor:
Nicolas Altemose, Glennis A. Logsdon, Andrey V. Bzikadze, Pragya Sidhwani, Sasha A. Langley, Gina V. Caldas, Savannah J. Hoyt, Lev Uralsky, Fedor D. Ryabov, Colin J. Shew, Michael E. G. Sauria, Matthew Borchers, Ariel Gershman, Alla Mikheenko, Valery A. Shepelev, Tatiana Dvorkina, Olga Kunyavskaya, Mitchell R. Vollger, Arang Rhie, Ann M. McCartney, Mobin Asri, Ryan Lorig-Roach, Kishwar Shafin, Julian K. Lucas, Sergey Aganezov, Daniel Olson, Leonardo Gomes de Lima, Tamara Potapova, Gabrielle A. Hartley, Marina Haukness, Peter Kerpedjiev, Fedor Gusev, Kristof Tigyi, Shelise Brooks, Alice Young, Sergey Nurk, Sergey Koren, Sofie R. Salama, Benedict Paten, Evgeny I. Rogaev, Aaron Streets, Gary H. Karpen, Abby F. Dernburg, Beth A. Sullivan, Aaron F. Straight, Travis J. Wheeler, Jennifer L. Gerton, Evan E. Eichler, Adam M. Phillippy, Winston Timp, Megan Y. Dennis, Rachel J. O’Neill, Justin M. Zook, Michael C. Schatz, Pavel A. Pevzner, Mark Diekhans, Charles H. Langley, Ivan A. Alexandrov, Karen H. Miga
Publikováno v:
Science
INTRODUCTION: To faithfully distribute genetic material to daughter cells during cell division, spindle fibers must couple to DNA by means of a structure called the kinetochore, which assembles at each chromosome’s centromere. Human centromeres are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6fdde181caa00d2a2585b6b9de02d9
https://doi.org/10.1101/2021.07.12.452052
https://doi.org/10.1101/2021.07.12.452052
Autor:
Robin A. Herbert, Jenny C. Mortimer, Venkataramana R. Pidatala, Aindrila Mukhopadhyay, Elijah Hoffman, Mina J. Bissell, Brenda Wang, Joseph C. Chen, Sasha A. Langley, Thomas Eng, James B. Brown, Kenneth H. Wan, Uriel Martinez
Publikováno v:
Environmental Toxicology and Chemistry
Advances in engineering biology have expanded the list of renewable compounds that can be produced at scale via biological routes from plant biomass. In most cases, these chemical products have not been evaluated for effects on biological systems, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6a1dc6934de9a80d25c960fb25f7b0
https://doi.org/10.1002/etc.4501
https://doi.org/10.1002/etc.4501
Autor:
Gabriela Fuentes-Creollo, Antoine M. Snijders, Yan Xia Zhou, Kuang-Yu Jen, Frank Ponce, Susan E. Celniker, Jian-Hua Mao, Sasha A. Langley
Publikováno v:
Molecular Carcinogenesis. 58:627-632
Variations in oral bacterial communities have been linked to oral cancer suggesting that the oral microbiome is an etiological factor that can influence oral cancer development. The 4-nitroquinoline 1-oxide (4-NQO)-induced murine oral and esophageal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735f55a145eca068651c89ab69ed96ff
https://doi.org/10.1002/mc.22972
https://doi.org/10.1002/mc.22972
Autor:
Sasha A. Langley, Sylvain V. Costes, Gary H. Karpen, Duc A. Tran, Hung Nguyen, Egle Cekanaviciute, Sherina Malkani, Eloise Pariset, Giulia Babbi, Alejandra Lopez Macha, Sébastien Penninckx, Tin Nguyen, Jonathan C. Schisler
Publikováno v:
SSRN Electronic Journal.
Exposure to ionizing radiation is marked by NASA as a major health hazard for deep space exploration missions. Ionizing radiation sensitivity is determined by both genomic and environmental factors. Understanding their contributions is crucial for de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b12d06e411693cfc748b2cb2b3c7702
https://doi.org/10.2139/ssrn.3927423
https://doi.org/10.2139/ssrn.3927423
Autor:
Colin J. Brislawn, Yan Xia Zhou, Jian-Hua Mao, Janet K. Jansson, Carolina Mantilla Rojas, Kuang-Yu Jen, Qi Sun, David W. Threadgill, Sasha A. Langley, Antoine M. Snijders, Xiaoping Zou, Pin Wang, Susan E. Celniker, Kimberly L. Wahl, Xiangshan Fan, Yunshan Wang, Ting Wang
Publikováno v:
Gut, vol 68, iss 11
Gut
Gut
ObjectiveThe Collaborative Cross (CC) is a mouse population model with diverse and reproducible genetic backgrounds used to identify novel disease models and genes that contribute to human disease. Since spontaneous tumour susceptibility in CC mice r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16030622b3b690bbc090637cfc8342bb
https://escholarship.org/uc/item/1f4294sh
https://escholarship.org/uc/item/1f4294sh