Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Sasha A, Singh"'
Autor:
Takehito Okui, Shiori Kuraoka, Masaya Iwashita, Rei Itagawa, Taku Kasai, Masanori Aikawa, Sasha A. Singh, Elena Aikawa
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Introduction: Carnitine O-octanoyltransferase (CROT) is a well-established peroxisomal enzyme involved in liver fatty acid oxidation, but less is known about its recently discovered role in promoting vascular calcification, and whether CROT-dependent
Externí odkaz:
https://doaj.org/article/59d59852e3244becb85811d9c1542387
Autor:
Allison B. Andraski, Sasha A. Singh, Hideyuki Higashi, Lang Ho Lee, Masanori Aikawa, Frank M. Sacks
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Apolipoprotein A4’s (APOA4’s) functions on HDL in humans are not well understood. A unique feature of APOA4 is that it is an intestinal apolipoprotein secreted on HDL and chylomicrons. The goal of this study was to gain a better understanding of
Externí odkaz:
https://doaj.org/article/79c6d11069c8483faa5d05c44be20f3e
Autor:
Sneha Raju, Kamalben Prajapati, Mark C. Blaser, Steven R. Botts, Tse Wing Winnie Ho, Crizza Ching, Natalie J. Galant, Lindsey Fiddes, Ruilin Wu, Cassandra L. Clift, Tan Pham, Sasha A. Singh, Warren L. Lee, Elena Aikawa, Jason Fish, Kathryn Howe
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100166- (2023)
Externí odkaz:
https://doaj.org/article/695aa1d2d0fe40bb80b113d360953c55
Autor:
Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E Wheelock, Sasha A Singh, Masanori Aikawa, Lois E Smith, Richard L Proia, Timothy Hla
Publikováno v:
eLife, Vol 11 (2022)
Serine palmitoyl transferase (SPT), the rate-limiting enzyme in the de novo synthesis of sphingolipids (SL), is needed for embryonic development, physiological homeostasis, and response to stress. The functions of de novo SL synthesis in vascular end
Externí odkaz:
https://doaj.org/article/e21f8001eecc472486c15e1a9e2ebd82
Publikováno v:
Pathogens, Vol 12, Iss 7, p 964 (2023)
Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is associated with multiple disease processes such as infections and chronic inflammatory diseases. The poly(ADP-ribose) polymerase (PARP)/ADP-ribosyltransferase (
Externí odkaz:
https://doaj.org/article/98724d0c5a31454fb7b07fe6ab4a96c0
Autor:
Stephanie Morgan, Lang Ho Lee, Arda Halu, Jessica S. Nicolau, Hideyuki Higashi, Anna H. Ha, Jennifer R. Wen, Alan Daugherty, Peter Libby, Scott J. Cameron, Doran Mix, Elena Aikawa, A. Phillip Owens, Sasha A. Singh, Masanori Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundAbdominal aortic aneurysm (AAA), characterized by a continued expansion of the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease progression and its underlying mechanisms since sequential studies of aneurysm
Externí odkaz:
https://doaj.org/article/4f75d774fba942649f894b3d30b21865
Autor:
Samantha K. Atkins, Abhijeet R. Sonawane, Romi Brouwhuis, Johana Barrientos, Anna Ha, Maximillian Rogers, Takeshi Tanaka, Takehito Okui, Shiori Kuraoka, Sasha A. Singh, Masanori Aikawa, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Cardiovascular calcification is the lead predictor of cardiovascular events and the top cause of morbidity and mortality worldwide. To date, only invasive surgical options are available to treat cardiovascular calcification despite the growing unders
Externí odkaz:
https://doaj.org/article/b26ad268a87d40c4af998ae76d91abbc
Autor:
Sasha A. Singh, Shiori Kuraoka, Diego Vinicius Santinelli Pestana, Waqas Nasir, Bernard Delanghe, Masanori Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ADP-ribosylation is a post-translational modification that is catalyzed by the ADP-ribosyltransferase enzyme family. Major emphasis to date has been ADP-ribosylation's role in cancer; however, there is growing interest in its role in inflammation and
Externí odkaz:
https://doaj.org/article/e9e23e278a154c6d8cc73db661a9429d
Autor:
Takeshi Tanaka, Takaharu Asano, Takehito Okui, Shiori Kuraoka, Sasha A. Singh, Masanori Aikawa, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
Vascular calcification is a cardiovascular disorder with no therapeutic options. We recently reported that o-octanoyltransferase (CROT) suppression can inhibit vascular calcification in vivo and in vitro through amelioration of mitochondrial function
Externí odkaz:
https://doaj.org/article/3aa72124cf314fb8aa57e1c137cf026a
Autor:
Maximillian A. Rogers, Samantha K. Atkins, Kang H. Zheng, Sasha A. Singh, Sarvesh Chelvanambi, Tan H. Pham, Shiori Kuraoka, Erik S. G. Stroes, Masanori Aikawa, Elena Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Lipoprotein(a) (Lp[a]) blood levels >50 mg/dL is a major cardiovascular disease risk factor in humans. Lp(a) associates with increased cardiovascular calcification, a critical pathology with no clinically available drug therapies. The mechanisms thro
Externí odkaz:
https://doaj.org/article/a63d7c1e04bd4154820fe79dd6cd8b0f