Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sascha Young Kupke"'
Autor:
Lars Pelz, Elena Piagnani, Patrick Marsall, Nancy Wynserski, Marc Dominique Hein, Pavel Marichal-Gallardo, Sascha Young Kupke, Udo Reichl
Publikováno v:
Viruses, Vol 15, Iss 9, p 1872 (2023)
New broadly acting and readily available antiviral agents are needed to combat existing and emerging viruses. Defective interfering particles (DIPs) of influenza A virus (IAV) are regarded as promising options for the prevention and treatment of IAV
Externí odkaz:
https://doaj.org/article/6e9ede8ffa674c76984914b8a83d92f0
Autor:
Ulfert Rand, Sascha Young Kupke, Hanna Shkarlet, Marc Dominique Hein, Tatjana Hirsch, Pavel Marichal-Gallardo, Luka Cicin-Sain, Udo Reichl, Dunja Bruder
Publikováno v:
Cells, Vol 10, Iss 7, p 1756 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) emerged in late 2019 and resulted in a devastating pandemic. Although the first approved vaccines were already administered by the end of 2020, w
Externí odkaz:
https://doaj.org/article/20cc19c826684effad1bc1af351970b0
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006819 (2019)
Influenza A viruses (IAV) are commonly used to infect animal cell cultures for research purposes and vaccine production. Their replication is influenced strongly by the multiplicity of infection (MOI), which ranges over several orders of magnitude de
Externí odkaz:
https://doaj.org/article/fba0470dd37b454a99981e7e1ffa08ca
Autor:
Sascha Young Kupke, Lam-Ha Ly, Stefan Thomas Börno, Alexander Ruff, Bernd Timmermann, Martin Vingron, Stefan Haas, Udo Reichl
Publikováno v:
Viruses, Vol 12, Iss 1, p 71 (2020)
Virus replication displays a large cell-to-cell heterogeneity; yet, not all sources of this variability are known. Here, we study the effect of defective interfering (DI) particle (DIP) co-infection on cell-to-cell variability in influenza A virus (I
Externí odkaz:
https://doaj.org/article/18f1b070875c4c7697ab19ed2155f8b0
Autor:
Tanya Dogra, Christopher B. Brooke, Udo Reichl, Fadi G. Alnaji, Sascha Young Kupke, Daniel Rüdiger, Yvonne Genzel, Lars Pelz
Publikováno v:
Journal of Virology
Defective interfering particles (DIPs) of influenza A virus (IAV) are naturally occurring mutants that comprise an internal deletion in one of their eight viral RNA (vRNA) segments, rendering them propagation-incompetent. Upon co-infection with infec
Autor:
Hanna Shkarlet, Dunja Bruder, Sascha Young Kupke, Marc D. Hein, Ulfert Rand, Tatjana Hirsch, Udo Reichl, Pavel Marichal-Gallardo, Luka Cicin-Sain
Publikováno v:
Cells
Cells, Vol 10, Iss 1756, p 1756 (2021)
Cells, Vol 10, Iss 1756, p 1756 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) emerged in late 2019 and resulted in a devastating pandemic. Although the first approved vaccines were already administered by the end of 2020, w
Autor:
Anshika Chawla, Udo Reichl, Maurizio Cattaneo, Sascha Young Kupke, Marc D. Hein, Yvonne Genzel
Publikováno v:
Applied Microbiology and Biotechnology
Respiratory diseases including influenza A virus (IAV) infections represent a major threat to human health. While the development of a vaccine requires a lot of time, a fast countermeasure could be the use of defective interfering particles (DIPs) fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d78280f18d22d5145d266f0313f5ea
https://doi.org/10.1101/2021.06.07.446880
https://doi.org/10.1101/2021.06.07.446880
Autor:
Yvonne Genzel, Udo Reichl, Marc D. Hein, Pavel Marichal-Gallardo, Sascha Young Kupke, Klaus Schughart, Prerna Arora, Michael Winkler, Stefan Pöhlmann
Publikováno v:
BMC biology
England
BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
England
BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Background Infections with influenza A virus (IAV) cause high morbidity and mortality in humans. Additional to vaccination, antiviral drugs are a treatment option. Besides FDA-approved drugs such as oseltamivir or zanamivir, virus-derived defective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa62b74248ffe9fa212e5663ce35c58
https://hdl.handle.net/10033/622927
https://hdl.handle.net/10033/622927
Autor:
Dunja Bruder, Tatjana Hirsch, Luka Cicin-Sain, Marc D. Hein, Udo Reichl, Pavel Marichal-Gallardo, Ulfert Rand, Sascha Young Kupke, Hanna Shkarlet
SARS-CoV-2 causing COVID-19 emerged in late 2019 and resulted in a devastating pandemic. Although the first approved vaccines were already administered by the end of 2020, worldwide vaccine availability is still limited. Moreover, immune escape varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8812506997938f33b75602c91931cd07
https://doi.org/10.1101/2021.02.19.431972
https://doi.org/10.1101/2021.02.19.431972
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 9, p e1009357 (2021)
PLoS Computational Biology, Vol 17, Iss 9, p e1009357 (2021)
Cell culture-derived defective interfering particles (DIPs) are considered for antiviral therapy due to their ability to inhibit influenza A virus (IAV) production. DIPs contain a large internal deletion in one of their eight viral RNAs (vRNAs) rende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e3639ce988d1d18e377d5a30adb992
https://hdl.handle.net/21.11116/0000-0009-40F1-E21.11116/0000-0009-40F3-C
https://hdl.handle.net/21.11116/0000-0009-40F1-E21.11116/0000-0009-40F3-C