Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sascha Stump"'
Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205584 (2018)
The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III1 region of the c-MYC promoter forms a DNA quadruplex. Stabilization of this structure with small mole
Externí odkaz:
https://doaj.org/article/d4e11fbb95874064b04098d7986a2101
Autor:
Nathan S, Duncan, Michael J, Campbell, Donald S, Backos, Chun, Li, Kevin C, Rider, Sascha, Stump, Matthew J, Weaver, Mariusz P, Gajewski, Howard D, Beall, Philip, Reigan, Nicholas R, Natale
Publikováno v:
Bioorganic & Medicinal Chemistry. 69:116911
A series of 10-alkoxy-Anthryl-isoxazole-pyrrole-doubletails (RO-AIMs) were synthesized using a crown ether assisted nucleophilic aromatic substitution followed by a modified Schotten-Baumann reaction. The novel RO-AIMs described here exhibit robust g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccee4d5afc7462c5948103272ecee7bc
https://doi.org/10.1016/j.bmc.2022.116911
https://doi.org/10.1016/j.bmc.2022.116911
Autor:
Nicholas R. Natale, Earle Adams, Matthew J. Weaver, Donald S. Backos, Sascha Stump, Philip Reigan, Michael J. Campbell, Chun Li, Howard D. Beall
Publikováno v:
Bioorg Med Chem
A novel series of anthracenyl-isoxazole amide (AIM) antitumor agents containing N-heterocycles in the 10 position (N-het) were synthesized using palladium cross-coupling. The unique steric environment of the N-het-AIMs required individual optimizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d6d7202a31a6482706516f788a081a
https://doi.org/10.1016/j.bmc.2020.115781
https://doi.org/10.1016/j.bmc.2020.115781
Autor:
Mariusz P. Gajewski, Donald S. Backos, Alison K. Kearns, Howard D. Beall, Kevin C. Rider, Sascha Stump, Matthew J. Weaver, Nicholas R. Natale, Philip Reigan, Chun Li
Using the structure–activity relationship emerging from previous Letter, and guided by pharmacokinetic properties, new AIMs have been prepared with both improved efficacy against human glioblastoma cells and cell permeability as determined by fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198d9822e9d4578caa8af7dbb8505b14
https://europepmc.org/articles/PMC4599781/
https://europepmc.org/articles/PMC4599781/
