Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sascha R.A. Alles"'
Publikováno v:
Neurobiology of Pain, Vol 13, Iss , Pp 100128- (2023)
Chronic pain affects approximately one-fifth of people worldwide and reduces quality of life and in some cases, working ability. Ion channels expressed along nociceptive pathways affect neuronal excitability and as a result modulate pain experience.
Externí odkaz:
https://doaj.org/article/9a242aba64a141cb86097966abe682a5
Autor:
Justin E. LaVigne, Sascha R.A. Alles
Publikováno v:
Neurobiology of Pain, Vol 11, Iss , Pp 100092- (2022)
The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target. In th
Externí odkaz:
https://doaj.org/article/1951eac9bea74cb187c893689e7e95cb
Publikováno v:
Neurobiology of Pain, Vol 8, Iss , Pp 100050- (2020)
Large amino acid transporter 1 (LAT1), also known as SLC7A5, is an essential amino acid transporter that forms a heterodimeric complex with the glycoprotein cell-surface antigen heavy chain (4F2hc (CD98, SLC3A2)). Within nociceptive pathways, LAT1 is
Externí odkaz:
https://doaj.org/article/fbdf77d62fd04e76b4f191ccd60527e0
Autor:
M.A. Bangash, Sascha R.A. Alles, Sonia Santana-Varela, Queensta Millet, Shafaq Sikandar, Larissa de Clauser, Freija ter Heegde, Abdella M. Habib, Vanessa Pereira, Jane E. Sexton, Edward C. Emery, Shengnan Li, Ana P. Luiz, Janka Erdos, Samuel J. Gossage, Jing Zhao, James J. Cox, John N. Wood
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expres
Externí odkaz:
https://doaj.org/article/321b7fa64d604323a2606b1a61824c71
Autor:
Morgan Zhang, Min Hu, Sascha R.A. Alles, Marena A. Montera, Ian Adams, Maria D. Santi, Kenji Inoue, Nguyen Huu Tu, Karin N. Westlund, Yi Ye
Publikováno v:
Neuropharmacology
Chemotherapy-induced neuropathic pain (CINP) is a debilitating and difficult-to-treat side effect of chemotherapeutic drugs. CINP is marked with oxidative stress and neuronal hypersensitivities. The peroxisome proliferator-activated receptor gamma (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e0d86b1e4c4c5eeb92e8c54bc3b987
https://europepmc.org/articles/PMC9574783/
https://europepmc.org/articles/PMC9574783/
Autor:
Leos Cmarko, Sascha R.A. Alles, Marena A. Montera, Aleyah Goins, Karin N. Westlund, Norbert Weiss
Publikováno v:
Channels
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In this brief report, we demonstrate that the Cav3.3 T-type voltage-gated calcium channel subtype is involved in our FRICT-ION model of chronic trigeminal neuropathic pain. We first showed that the Cacna1i gene encoding Cav3.3 is significantly upregu
Autor:
Marena A. Montera, Aleyah Goins, Sascha R.A. Alles, R. Bartel, M. Afaghpour-Becklund, Adinarayana Kunamneni, Karin N. Westlund, Ravi Durvasula
Publikováno v:
Neurobiology of Pain, Vol 10, Iss, Pp 100067-(2021)
Neurobiology of Pain
Neurobiology of Pain
Highlights • Ribosome display used for recombinant antibody selection and scFv generation targeting CCK-BR. • Engineered scFv have stronger affinity and increased tissue penetrability due to smaller size. • Single dose scFv reduces hypersensiti
Publikováno v:
Cureus
The intrathecal drug delivery system (IDDS) is successfully utilized for the treatment of chronic pain conditions; however, they are associated with complications related to human error and system failure. A case report is presented of a patient with
Publikováno v:
The FASEB Journal. 35
Autor:
Sascha R.A. Alles, Peter A. Smith
Publikováno v:
Neuroscience Letters. 694:148-153
Although gabapentin (GBP) is a first-line treatment in the management of neuropathic pain, its mechanism of action is incompletely understood. We have previously shown, in rats made neuropathic following sciatic chronic constriction injury, that IP i