Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sascha Röth"'
Autor:
Natalia V. Ortiz Zacarías, Sascha Röth, Jeremy D. Broekhuis, Daan van der Es, Kevin Moreau, Laura H. Heitman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8984 (2024)
CC chemokine receptor 2 (CCR2) has been linked to many inflammatory and immune diseases, making it a relevant drug target. Yet, all CCR2 antagonists developed so far have failed in clinical trials; thus, novel strategies are needed to target this rec
Externí odkaz:
https://doaj.org/article/6db528a29d49459988b2161f531381fd
Publikováno v:
Targeted Protein Degradation ISBN: 9780323992008
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903bb06cf16061ca3d343e0a9d3c5a33
https://doi.org/10.1016/bs.mie.2022.08.011
https://doi.org/10.1016/bs.mie.2022.08.011
Autor:
Peter Stacey, Gopal P. Sapkota, Georgina Green, Hannah Lithgow, Marcel Muelbaier, Glenn A. Burley, Andrew B. Benowitz, Ian Edward David Smith, Xiao Qing Lewell, Ryan Whatling, Markus A. Queisser, Agnieszka Konopacka, Robert P. Law, Stephen Besley, John D. Harling, Sascha Röth
Publikováno v:
SLAS Discovery. 26:885-895
Targeted protein degradation is an emerging new strategy for the modulation of intracellular protein levels with applications in chemical biology and drug discovery. One approach to enable this strategy is to redirect the ubiquitin-proteasome system
Autor:
Sascha Röth, Bill Carton, Preethi S. Sathyamurthi, Matthew Watt, Thomas J. Macartney, Kwok-Ho Chan, Albert Isidro-Llobet, Agnieszka Konopacka, Markus A. Queisser, Gopal Sapkota
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
The Plant Journal. 89:31-44
HsfB1 is a central regulator of heat stress (HS) response and functions dually as a transcriptional co-activator of HsfA1a and a general repressor in tomato. HsfB1 is efficiently synthesized during the onset of HS and rapidly removed in the course of
For over three decades,K-RAShas been known as the holy grail of cancer targets, one of the most frequently mutated oncogenes in cancer. Because the development of conventional small molecule K-RAS inhibitors has been extremely challenging, K-RAS has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0997d6de2ddab735b4e80b38a6b0b94
https://doi.org/10.1101/805150
https://doi.org/10.1101/805150
Publikováno v:
Plant Reproduction. 29:53-65
Protein translocation. Cellular homeostasis strongly depends on proper distribution of proteins within cells and insertion of membrane proteins into the destined membranes. The latter is mediated by organellar protein translocation and the complex ve
Autor:
Sascha Röth, Ian G. Ganley, Luke M. Simpson, Alice Nardin, Thomas Macartney, Gopal P. Sapkota, Chiara Maniaci, Andrea Testa, Alessio Ciulli, Luke J. Fulcher
Publikováno v:
Cell Chemical Biology
Summary The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI. However, a chemica
Autor:
Agnieszka Konopacka, Markus A. Queisser, Gopal P. Sapkota, Kwok-Ho Chan, Sascha Röth, Thomas Macartney, Houjiang Zhou
Publikováno v:
Cell Chemical Biology
Summary K-RAS is known as the most frequently mutated oncogene. However, the development of conventional K-RAS inhibitors has been extremely challenging, with a mutation-specific inhibitor reaching clinical trials only recently. Targeted proteolysis
Publikováno v:
Molecular Cancer Research. 18:B34-B34
K-RAS is one of the most frequently mutated oncogenes in cancer. Yet there are no effective strategies to target K-RAS for inhibition. Our laboratory has developed an Affinity-directed PROtein Missile (AdPROM) system for targeted proteolysis of endog