Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sascha Obrowsky"'
Autor:
Melanie Korbelius, Nemanja Vujic, Vinay Sachdev, Sascha Obrowsky, Silvia Rainer, Benjamin Gottschalk, Wolfgang F. Graier, Dagmar Kratky
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1923-1934.e4 (2019)
Summary: As circulating lipid levels are balanced by the rate of lipoprotein release and clearance from the plasma, lipid absorption in the small intestine critically contributes to the maintenance of whole-body lipid homeostasis. Within enterocytes,
Externí odkaz:
https://doaj.org/article/a4742c9cc05945e782afeea75541f01a
Autor:
Madeleine Goeritzer, Stefanie Schlager, Branislav Radovic, Corina T. Madreiter, Silvia Rainer, Gwynneth Thomas, Caleb C. Lord, Jessica Sacks, Amanda L. Brown, Nemanja Vujic, Sascha Obrowsky, Vinay Sachdev, Dagmar Kolb, Prakash G. Chandak, Wolfgang F. Graier, Wolfgang Sattler, J. Mark Brown, Dagmar Kratky
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2562-2575 (2014)
Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases ATGL-mediated TG catabolism in cell culture experiments. To investigate the consequences of CGI-
Externí odkaz:
https://doaj.org/article/6c08cfbd5a4e4241921cb0bb76dbc68b
Autor:
Clemens Röhrl, Karin Eigner, Katharina Winter, Melanie Korbelius, Sascha Obrowsky, Dagmar Kratky, Werner J. Kovacs, Herbert Stangl
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 1, Pp 94-103 (2014)
Metabolic disorders such as type 2 diabetes cause hepatic endoplasmic reticulum (ER) stress, which affects neutral lipid metabolism. However, the role of ER stress in cholesterol metabolism is incompletely understood. Here, we show that induction of
Externí odkaz:
https://doaj.org/article/14aa0f6ee53e4a5c82b316d0efa5417c
Autor:
Sascha Obrowsky, Prakash G. Chandak, Jay V. Patankar, Silvia Povoden, Stefanie Schlager, Erin E. Kershaw, Juliane G. Bogner-Strauss, Gerald Hoefler, Sanja Levak-Frank, Dagmar Kratky
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 2, Pp 425-435 (2013)
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme mediating triglyceride (TG) hydrolysis. The lack of ATGL results in TG accumulation in multiple tissues, underscoring the critical role of ATGL in maintaining lipid homeostasis. Recent ev
Externí odkaz:
https://doaj.org/article/89c9b262ad324158ae8a8b4067e495ba
Autor:
Melanie Korbelius, Nemanja Vujić, Katharina B. Kuentzel, Sascha Obrowsky, Silvia Rainer, Guenter Haemmerle, Thomas Rülicke, Dagmar Kratky
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1867:159121
Enterocytes of the small intestine (SI) play an important role in maintaining systemic lipid levels by regulating dietary lipid absorption and postprandial lipoprotein secretion. An excessive amount of dietary-derived triglycerides (TGs) taken up by
Autor:
Vinay, Sachdev, Christina, Leopold, Raimund, Bauer, Jay V, Patankar, Jahangir, Iqbal, Sascha, Obrowsky, Renze, Boverhof, Marcela, Doktorova, Bernhard, Scheicher, Madeleine, Goeritzer, Dagmar, Kolb, Andrew V, Turnbull, Andreas, Zimmer, Gerald, Hoefler, M Mahmood, Hussain, Albert K, Groen, Dagmar, Kratky
Publikováno v:
Biochimica et biophysica acta
Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and pharmacological inhibition of DGAT1 in mice alters cholesterol metabolism. Cholesterol absorption, as ass
Autor:
Prakash Doddapattar, Sascha Obrowsky, Gerald Hoefler, Dagmar Kratky, Sanja Levak-Frank, Michele A. Battle, Jay V. Patankar
Publikováno v:
Journal of Hepatology
Background & Aims GATA4, a zinc finger domain transcription factor, is critical for jejunal identity. Mice with an intestine-specific GATA4 deficiency ( GATA4 iKO) are resistant to diet-induced obesity and insulin resistance. Although they have decre
Autor:
Thomas Pfeifer, Prakash G. Chandak, Gerald N. Rechberger, Rajendra S. Kadam, Adelheid Kratzer, Uday B. Kompella, Sanja Levak-Frank, Jay V. Patankar, Gerhard M. Kostner, Marlene Buchebner, Sascha Obrowsky, Dagmar Kratky
Publikováno v:
Current Pharmaceutical Biotechnology. 12:285-292
The liver X receptors (LXRs) are key regulators of genes involved in cholesterol homeostasis. Natural ligands and activators of LXRs are oxysterols. Numerous steroidal and non-steroidal synthetic LXR ligands are under development as potential drugs f
Autor:
Lalit S. Doshi, Branislav Radovic, Dagmar Kratky, Prakash G. Chandak, Gerald Hoefler, Adelheid Kratzer, Elma Aflaki, Silvia Povoden, Sascha Obrowsky, Sanja Levak-Frank, Prakash Doddapattar, Helmut Ahammer
Publikováno v:
Biochimica et Biophysica Acta
Triacylglycerols (TG) are the major storage molecules of metabolic energy and fatty acids in several tissues. The final step in TG biosynthesis is catalyzed by acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes. Lack of whole body DGAT1 is associ
Autor:
Sascha Obrowsky, Karl Gruber, Bianca Hecher, Margit Winkler, Ulrike Schreiner, J. David Rozzell, Norbert Klempier, Georg Steinkellner, Anton Glieder, Kerstin Waich
Publikováno v:
Enzyme and Microbial Technology. 47:140-146
Alcaligenes faecalis nitrilase (NITAf) was engineered in a directed evolution approach towards increased activity at its optimal pH as well as improved fitness at low pH values. Error prone PCR in combination with recombination of beneficial mutation