Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sascha Meyer dos Santos"'
Autor:
Stefanie Frölich, Gerd Geisslinger, Sascha Meyer dos Santos, Nerea Ferreirós, Dominique Thomas, Bona Linke, Domenico Del Turco, Neda Tarighi, Klaus Scholich, Jing Suo, Marco Sisignano, Thomas Deller, Rolf M. Nüsing, Bernhard Nieswandt, Sandra Pierre, Natasja deBruin, David Stegner
Publikováno v:
Journal of Investigative Dermatology. 137:686-695
Platelets are well known for their role in hemostasis but are also increasingly recognized for their supporting role in innate immune responses. Here, we studied the role of platelets in the development of peripheral inflammation and found that plate
Publikováno v:
Seminars in thrombosis and hemostasis. 45(3)
An universal coagulation test that reliably detects prolonged coagulation times in patients, regardless of which anticoagulant is administered, is not yet available. The authors developed a novel, miniaturized device utilizing surface acoustic waves
Autor:
Martine C J Hofmann, Yannick Schreiber, Michael Schmidt, Clifford J. Woolf, Ruirui Lu, Dong-Dong Zhang, Carlo Angioni, Di Liu, Marco Sisignano, Ru-Rong Ji, Jing Suo, Maria Kuzikov, Stephan W. Hohman, Ajay S. Yekkirala, Sascha Meyer dos Santos, Sebastian Zinn, Klaus Scholich, Chul-Kyu Park, Béla Zimmer, Stephan M. G. Schäfer, Michael J. Parnham, Gerd Geisslinger, Holger Jordan, Natasja de Bruin
Publikováno v:
Proceedings of the National Academy of Sciences. 113:12544-12549
Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose- and therapy-limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we report increased expression of the cytochrome-P450-epoxygenase CY
Publikováno v:
Drug Safety. 37:295-307
Non-valvular atrial fibrillation (NVAF) is the most common clinically significant cardiac arrhythmia and is a common cause of stroke. The direct thrombin inhibitor dabigatran etexilate is approved for a variety of indications requiring anticoagulatio
Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation
Autor:
Sascha Meyer dos Santos, Klaus Scholich, Sandra Pierre, Bona Linke, Bernhard Nieswandt, David Stegner, Dong Dong Zhang, Jing Suo, Cécile V. Denis, Gerd Geisslinger
Publikováno v:
Journal of Leukocyte Biology. 96:133-142
Inflammatory pain is based on stimulation and sensitization of peripheral endings of sensory neurons (nociceptors) by pronociceptive mediators. These mediators can be released by resident cells, as well as invading immune cells. Although neutrophils
Publikováno v:
Platelets. 21:60-66
This article intends to close the gap between the abundance of regular articles focusing on adhesive mechanisms of cells in a flow field and purely technical reports confined to the description of newly developed algorithms, not yet ready to be used
Autor:
Sebastian Harder, Bettina Picard-Willems, Karina Kuczka, Karen Nelson, Sascha Meyer dos Santos, Ute Klinkhardt
Publikováno v:
Platelets. 26(1)
The RGD cyclic pentapetide, cilengitide, is a selective inhibitor of αvβ3 and αvβ5 integrins and was developed for antiangiogenic therapy. Since cilengitide interacts with platelet αIIbβ3 and platelets express αv integrins, the effect of cilen
Autor:
Sascha, Meyer dos Santos, Sascha, Meyer Dos Santos, Claudia-Carolin, Weber, Cornelia, Franke, Walter E, Müller, Gunter P, Eckert
Publikováno v:
Biochemical and biophysical research communications. 354(1)
Lipid composition of biological membranes is closely related to the function of the ATP-binding cassette (ABC) transporter P-Glycoprotein (Pgp). Herein, we studied how membrane physico-chemical properties affect Pgp-activity. We effectively modulated
Autor:
Christoph Wiesner, Eva Juengel, Sascha Meyer dos Santos, Jasmina Makarević, Tanja Schneider, Lukasz Hudak, Georg Bartsch, Axel Haferkamp, Roman A. Blaheta
Publikováno v:
Experimental biology and medicine (Maywood, N.J.). 238(11)
The influence of the histone deacetylase (HDAC)-inhibitor, valproic acid (VPA), on bladder cancer cell adhesion in vitro was investigated in this paper. TCCSUP and RT-112 bladder cancer cells were treated with VPA (0.5 or 1 mM) twice or thrice weekly
Autor:
Sebastian Harder, Sascha Meyer dos Santos, Nadejda Monsefi, Karina Kuczka, Hans Deckmyn, Karen Nelson, Ute Klinkhardt, Anita Zorn, Klaus Scholich
Publikováno v:
Blood. 117(18)
The membrane-anchored CX3C chemokine fractalkine (FKN) is expressed on activated endothelium and is associated with the development of atherosclerosis. The potential of FKN in mediating platelet adhesion beyond platelet activation remains unexplored