Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sascha Menninger"'
Autor:
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108839- (2024)
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders. Although existing drugs target ERBB receptors, the next generation of drugs requires enhanced sele
Externí odkaz:
https://doaj.org/article/ff5d053643f145278c5b251d0afc7838
Autor:
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Hannes C.A. Drexler, Sascha Menninger, Gunther Zischinsky, Jan Eickhoff, Claudia Fröb, Prabesh Bhattarai, Guruchandar Arulmozhivarman, Lara Marrone, Antje Janosch, Kenjiro Adachi, Martin Stehling, Eric N. Anderson, Masin Abo-Rady, Marc Bickle, Udai Bhan Pandey, Michell M. Reimer, Caghan Kizil, Hans R. Schöler, Peter Nussbaumer, Bert Klebl, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Summary: Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neu
Externí odkaz:
https://doaj.org/article/d6324808720f45358bb83abf2c104f0a
Autor:
Patricia Johansson, Laura Dierichs, Ludger Klein-Hitpass, Anke K. Bergmann, Michael Möllmann, Sascha Menninger, Peter Habenberger, Bert Klebl, Jens T. Siveke, Ulrich Dührsen, Axel Choidas, Jan Dürig
Publikováno v:
Therapeutic Advances in Hematology, Vol 11 (2020)
T-cell prolymphocytic leukemia (T-PLL) is an aggressive malignancy characterized by chemotherapy resistance and a median survival of less than 2 years. Here, we investigated the pharmacological effects of the novel highly specific cyclin-dependent ki
Externí odkaz:
https://doaj.org/article/dbaad95c53fa476da2bd0fedf8b2e735
Autor:
Blaž Andlovic, Geronimo Heilmann, Sabrina Ninck, Sebastian A. Andrei, Federica Centorrino, Yusuke Higuchi, Nobuo Kato, Luc Brunsveld, Michelle Arkin, Sascha Menninger, Axel Choidas, Alexander Wolf, Bert Klebl, Farnusch Kaschani, Markus Kaiser, Jan Eickhoff, Christian Ottmann
Publikováno v:
Cell Chemical Biology.
The natural product family of the fusicoccanes (FCs) has been shown to display anti-cancer activity, especially when combined with established therapeutic agents. FCs stabilize 14-3-3 protein-protein interactions (PPIs). Here, we tested combinations
Autor:
Jonas Lategahn, Hannah L. Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth, Lisa Werr, Janina Niggenaber, Marina Keul, Fatma Parmaksiz, Matthias Baumann, Sascha Menninger, Eldar Zent, Ina Landel, Jörn Weisner, Kirujan Jeyakumar, Leonie Heyden, Nicole Russ, Fabienne Müller, Carina Lorenz, Johannes Brägelmann, Inga Spille, Tobias Grabe, Matthias P. Müller, Johannes M. Heuckmann, Bert M. Klebl, Peter Nussbaumer, Martin L. Sos, Daniel Rauh
Publikováno v:
Journal of Medicinal Chemistry. 65:6643-6655
Despite the clinical efficacy of epidermal growth factor receptor (EGFR) inhibitors, a subset of patients with non-small cell lung cancer displays insertion mutations in exon20 in EGFR and Her2 with limited treatment options. Here, we present the dev
Autor:
Johanna B. Brüggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Brötzmann, Susanne Kordes, Sascha Menninger, Alexander Wolf, Elena Conti, Jan E. Eickhoff, Peter J. Murray
Publikováno v:
Journal of Biological Chemistry
mTORC1 and GCN2 are serine/threonine kinases that control how cells adapt to amino acid availability. mTORC1 responds to amino acids to promote translation and cell growth while GCN2 senses limiting amino acids to hinder translation via eIF2α phosph
Autor:
Bert Klebl, Martin Stehling, Lara Marrone, Peter Nussbaumer, Masin Abo-Rady, Antje Janosch, Jan Eickhoff, Matthias Baumann, Eric N. Anderson, Guruchandar Arulmozhivarman, Gunther Zischinsky, Kenjiro Adachi, Sascha Menninger, Marc Bickle, Peter Reinhardt, Claudia Fröb, Hannes C.A. Drexler, Michell M. Reimer, Jared Sterneckert, Michael Glatza, Susanne Kordes, Prabesh Bhattarai, Udai Bhan Pandey, Caghan Kizil, Lydia Reinhardt, Hans R. Schöler
Publikováno v:
Stem Cell Reports
Stem cell reports 12(3), 502-517 (2019). doi:10.1016/j.stemcr.2019.01.015
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Stem cell reports 12(3), 502-517 (2019). doi:10.1016/j.stemcr.2019.01.015
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Summary Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neur
Autor:
Peter Nussbaumer, Jan Eickhoff, Gabriel Sollberger, Axel Choidas, Arturo Zychlinsky, Renate Krüger, Garth L. Burn, Peter Habenberger, Sascha Menninger, Raffaella Di Lucrezia, Bert Klebl, Alf Herzig, Susanne Kordes
Publikováno v:
Science Immunology. 3
The death of a cell is an inevitable part of its biology. During homeostasis, most cells die through apoptosis. If homeostasis is disturbed, cell death can switch to proinflammatory forms of death, such as necroptosis, pyroptosis, or NETosis. We demo
Autor:
Janina Niggenaber, Martin L. Sos, Matthias Baumann, Roman K. Thomas, Johannes M. Heuckmann, Carsten Schultz-Fademrecht, Jonas Lategahn, Hannah L. Tumbrink, Carsten Degenhart, Lisa Hanna Werr, Marina Keul, Daniel Rauh, Bert Klebl, Alena Heimsoeth, Sascha Menninger
Publikováno v:
Journal of Clinical Oncology. 37:e14718-e14718
e14718 Background: The majority of EGFR mutant tumors can be effectively treated with targeted drugs. Lung adenocarcinoma patients with EGFR Ex20 insertion mutations, however, lack safe and potent treatment options. These genetic alterations share ho
Autor:
Herbert Waldmann, Réka Tóth, Michael J. Deeks, Rafael Martinez Gallegos, Katja Hübel, George Coupland, Sascha Menninger, Patrick J. Hussey, Isabella A. N. Tonaco, Claas Gerding-Reimers
Publikováno v:
The Plant Journal. 71:338-352
Chemical modulators are powerful tools to investigate biological processes. To identify circadian clock effectors, we screened a natural product library in the model plant Arabidopsis thaliana. Two compounds, prieurianin (Pri) and prieurianin acetate