Výsledky vyhledávání - "Sascha Hagemann"

Eukaryotic elongation factor 2 is a prognostic marker and its kinase a potential therapeutic target in HCC

Autor: Julia Kälsch, Henning Reis, Barbara Sitek, Dominik A. Megger, Frank Weber, Sascha Hagemann, Hideo A. Baba, Leona L. Pott, Kristina Lorenz, Boris V. Skryabin, Thilo Bracht, Thomas Herold

Publikováno v: Oncotarget

// Leona L. Pott 1, 2 , Sascha Hagemann 1 , Henning Reis 1 , Kristina Lorenz 3, 4, 5 , Thilo Bracht 2 , Thomas Herold 1 , Boris V. Skryabin 6 , Dominik A. Megger 2 , Julia Kalsch 1, 7 , Frank Weber 8 , Barbara Sitek 2 , Hideo A. Baba 1 1 Institute of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a776096dd1e6ad7276b91b8d92d3a17b
http://europepmc.org/articles/PMC5355317

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Loss of Survivin influences liver regeneration and is associated with impaired Aurora B function

Autor: Kristina Lorenz, Stefanie Bertram, Jeremias Wohlschlaeger, Sascha Hagemann, G. Pless-Petig, Bodo Levkau, G Kneiseler, Edward M. Conway, Hideo A. Baba, Andrea Musacchio, Barbara Sitek, D. Moellmann

Publikováno v: Cell Death & Differentiation. 20:834-844

The chromosomal passenger complex (CPC) acts as a key regulator of mitosis, preventing asymmetric segregation of chromosomal material into daughter cells. The CPC is composed of three non-enzymatic components termed Survivin, the inner centromere pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb116224ac2f166ff645ce944d4b7da
https://doi.org/10.1038/cdd.2013.20

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Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice

Autor: Christina Stoeckle, Eva Tolosa, Thomas Reinheckel, Christoph Peters, Sascha Hagemann, Lisa Sevenich

Publikováno v: Biochimie; Vol 92

A genetic deficiency of the cysteine protease cathepsin L (Ctsl) in mice results in impaired positive selection of conventional CD4+ T helper cells as a result of an incomplete processing of the MHC class II associated invariant chain or incomplete p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9426815b91736496545675a8e5d26c26
https://doi.org/10.1016/j.biochi.2010.03.014

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Reducing sample complexity of polyclonal human autoantibodies by chromatofocusing

Autor: Sascha Hagemann, Carmen Nölker, Michael Bacher, Richard Dodel, Alexander Faude, Monika Balzer-Geldsetzer, Monika Rabenstein

Publikováno v: Journal of Chromatography B. 878:2249-2254

Chromatofocusing was performed in order to separate a polyclonal antigen-specific mixture of human immunoglobulins (IgGs) that would then allow for further analyses of as few different IgGs as possible. Because polyclonal IgGs only differ by amino ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ab2f80929732ae0d694bf466c73b4e
https://doi.org/10.1016/j.jchromb.2010.06.039

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A structured proteomic approach identifies 14-3-3Sigma as a novel and reliable protein biomarker in panel based differential diagnostics of liver tumors

Autor: Ali Canbay, Hideo A. Baba, Carolin Pütter, Dominik A. Megger, Henning Reis, Barbara Sitek, Helmut E. Meyer, Jeremias Wohlschläger, Jörg F. Schlaak, AC Hoffmann, Frank Weber, André Scherag, Martin Eisenacher, Sascha Hagemann, Stefanie Bertram, Thilo Bracht

Publikováno v: Biochimica et biophysica acta. 1854(6)

Hepatocellular carcinoma (HCC) is a major lethal cancer worldwide. Despite sophisticated diagnostic algorithms, the differential diagnosis of small liver nodules still is difficult. While imaging techniques have advanced, adjuvant protein-biomarkers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5464e865ff5fc4f9bd2f97fe3266dd9a
https://pubmed.ncbi.nlm.nih.gov/25448011

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Proteome analysis of a hepatocyte-specific BIRC5 (survivin)-knockout mouse model during liver regeneration

Autor: Barbara Sitek, Thilo Bracht, Dominik A. Megger, Juliet Padden, Martin Eisenacher, Helmut E. Meyer, Sascha Hagemann, Marius Loscha, Katja Kuhlmann, Hideo A. Baba

Publikováno v: Journal of proteome research. 13(6)

The Baculoviral IAP repeat-containing protein 5 (BIRC5), also known as inhibitor of apoptosis protein survivin, is a member of the chromosomal passenger complex and a key player in mitosis. To investigate the function of BIRC5 in liver regeneration,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffd010a6f2b9ace7bbd6c50cdf5467e
https://pubmed.ncbi.nlm.nih.gov/24818710

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(Cleaved) CK18 serum and tissue expression levels differentiate acute HCV reinfection from acute rejection in liver allografts

Autor: Jeremias Wohlschläger, Ali Canbay, Anna-Carinna Suttorp, Martin Schlattjan, Lars P. Bechmann, Sascha Hagemann, Patricia Wenzel, Kerstin Herzer, Henning Reis, Hideo A. Baba

Publikováno v: Liver international : official journal of the International Association for the Study of the Liver. 35(3)

Background & Aims Orthotopic liver transplantation (OLT) is the sole therapeutic option to cure end-stage liver diseases including HCV-related cirrhosis. Timely and precise differentiation of relevant acute HCV reinfection from acute rejection after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8ca9396f39873f65aed65e7f55cbd7
https://pubmed.ncbi.nlm.nih.gov/24750688

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Cell type-specific functions of the lysosomal protease cathepsin L in the heart

Autor: Christoph Peters, Daniel Spira, Olga Vasiljeva, Roland Schüle, Desmond J. Tobin, Thomas Reinheckel, Jörg Stypmann, Thomas Günther, Christian Mayer, Ivonne Petermann, Sascha Hagemann

Publikováno v: The Journal of biological chemistry. 282(51)

Deficiency of the lysosomal cysteine protease cathepsin L (Ctsl) in mice results in a phenotype affecting multiple tissues, including thymus, epidermis, and hair follicles, and in the heart develops as a progressive dilated cardiomyopathy (DCM). To u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2d9213c9356dc2a0153703dda34011
https://pubmed.ncbi.nlm.nih.gov/17942402

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The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling

Autor: Gordana Zlatkovic, Thomas Reinheckel, Desmond J. Tobin, Christoph Peters, Sascha Hagemann, Elke Martinez, Tobias Lohmüller, Susanne Dollwet-Mack, Nicole Maas-Szabowski

Publikováno v: Journal of cell science. 118(Pt 15)

Mice deficient for cathepsin L (CTSL) show epidermal hyperplasia due to a hyperproliferation of basal keratinocytes. Here we show that the critical function of CTSL in the skin is keratinocyte specific. This is revealed by transgenic re-expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f19f91e1d73ed183167438bcfdc34b
https://pubmed.ncbi.nlm.nih.gov/16079282

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Toward computer-based cleavage site prediction of cysteine endopeptidases

Autor: Sascha Hagemann, Christoph Peters, Tobias Lohmüller, Thomas Dandekar, Daniel Wenzler, Wolfgang Kiess, Thomas Reinheckel

Publikováno v: Biological chemistry. 384(6)

Identification of relevant substrates is essential for elucidation of in vivo functions of peptidases. The recent availability of the complete genome sequences of many eukaryotic organisms holds the promise of identifying specific peptidase substrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a96a34be3b2799fb131f0894fb622e4
https://pubmed.ncbi.nlm.nih.gov/12887057

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