Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sascha Grobe"'
Autor:
Sascha Grobe, Thomas Bayer, Emil Hamnevik, Sven Koban, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Christoph W. Grathwol, Christoffel P. S. Badenhorst, Andreas Link, Henrike Brundiek
Publikováno v:
Angewandte Chemie (International Ed. in English)
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo‐ and regioselective 7β‐hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feccb8cafd3bf2be79c734a0ea0a0f96
https://doi.org/10.1002/anie.202012675
https://doi.org/10.1002/anie.202012675
Autor:
Christoffel P. S. Badenhorst, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Sven Koban, Thomas Bayer, Henrike Brundiek, Christoph W. Grathwol, Sascha Grobe, Emil Hamnevik, Andreas Link
Publikováno v:
Angewandte Chemie. 133:764-768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4fabe2b1189407420127e9a46b2bf9b
https://doi.org/10.1002/ange.202012675
https://doi.org/10.1002/ange.202012675
Publikováno v:
Biotechnology Letters
Objective Regio- and stereoselective hydroxylation of lithocholic acid (LCA) using CYP107D1 (OleP), a cytochrome P450 monooxygenase from the oleandomycin synthesis pathway of Streptomyces antibioticus. Results Co-expression of CYP107D1 from S. antibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f635dfcc6392bc4f8d5cea1d1983457
http://europepmc.org/articles/PMC7101289
http://europepmc.org/articles/PMC7101289
Autor:
Dominique Böttcher, Uwe T. Bornscheuer, Kathleen Balke, Lisa K. Morlock, Sascha Grobe, Stephan Mauersberger
Publikováno v:
ChemBioChem. 19:1954-1958
The CYP171 enzyme is known to catalyse a key step in the steroidogenesis of mammals. The substrates progesterone and pregnenolone are first hydroxylated at the C17 position, and this is followed by cleavage of the C17-C20 bond to yield important prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b9a2cb891f2c482aa408cdd967b04c
https://doi.org/10.1002/cbic.201800371
https://doi.org/10.1002/cbic.201800371
Publikováno v:
Integrative Medicine Research, Vol 10, Iss , Pp 100780- (2021)
Externí odkaz:
https://doaj.org/article/01215ea5808841238392564d06812e84