Výsledky vyhledávání - "Sascha Emilie Liberti"

Esc2 promotes telomere stability in response to DNA replication stress

Autor: Sascha Emilie Liberti, Nicolai B. Larsen, Michael Lisby, Ian D. Hickson, Signe W. Jørgensen, Hocine W. Mankouri

Publikováno v: Jørgensen, S W, Liberti, S E, Larsen, N B, Lisby, M, Mankouri, H W & Hickson, I D 2019, ' Esc2 promotes telomere stability in response to DNA replication stress ', Nucleic Acids Research, vol. 47, no. 9, pp. 4597-4611 . https://doi.org/10.1093/nar/gkz158
Nucleic Acids Research

Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form nucleoprotein complexes that can impede DNA replication fork progression. Precisely how cells respond to DNA r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3c566f2c5899fb3f774d5770afcfa8
https://doi.org/10.1093/nar/gkz158

Zobrazit plný text záznamu

Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae

Autor: Sascha Emilie Liberti, Jordan A. St Charles, Scott A. Lujan, Jessica S. Williams, Thomas A. Kunkel

Publikováno v: DNA Repair. 31:41-51

Mismatches generated during eukaryotic nuclear DNA replication are removed by two evolutionarily conserved error correction mechanisms acting in series, proofreading and mismatch repair (MMR). Defects in both processes are associated with increased s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13524087459a6f2185c970a4c820deee
https://doi.org/10.1016/j.dnarep.2015.04.006

Zobrazit plný text záznamu

Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro

Autor: Lene Juel Rasmussen, Sascha Emilie Liberti, Guido Keijzers, Anne Lützen, Dekang Liu, Jane H. Frederiksen, Javier Peña-Diaz

Publikováno v: Liu, D, Frederiksen, J H, Liberti, S E, Lützen, A, Keijzers, G, Pena-Diaz, J & Rasmussen, L J 2017, ' Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro ', Nucleic Acids Research, vol. 45, no. 16, pp. 9427-9440 . https://doi.org/10.1093/nar/gkx611
Nucleic Acids Research

DNA mismatch repair (MMR) is a highly-conserved DNA repair mechanism, whose primary role is to remove DNA replication errors preventing them from manifesting as mutations, thereby increasing the overall genome stability. Defects in MMR are associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5941a9fe7a36787f734a01f88cc43da4
https://curis.ku.dk/ws/files/186748905/gkx611.pdf

Zobrazit plný text záznamu

Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

Autor: Sascha Emilie Liberti, Vilhelm A. Bohr, Lene Juel Rasmussen, Guido Keijzers, Jean-Baptiste Charbonnier, Mylène Perderiset, Finn Cilius Nielsen, Jing Wang, Sofie Dabros Andersen, Alfred May, Simona Miron

Publikováno v: DNA Repair
DNA Repair, 2011, 10, pp.73-86. ⟨10.1016/j.dnarep.2010.09.023⟩
DNA Repair, Elsevier, 2011, 10, pp.73-86. ⟨10.1016/j.dnarep.2010.09.023⟩

Human exonuclease 1 (hEXO1) is implicated in DNA metabolism, including replication, recombination and repair, substantiated by its interactions with PCNA, DNA helicases BLM and WRN, and several DNA mismatch repair (MMR) proteins. We investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e16ab96c7acd73cdb1c8a85929a599
https://doi.org/10.1016/j.dnarep.2010.09.023

Zobrazit plný text záznamu

Cadmium inhibits human DNA mismatch repair in vivo

Autor: Anne Lützen, Sascha Emilie Liberti, Lene Juel Rasmussen

Publikováno v: Biochemical and Biophysical Research Communications. 321:21-25

The heavy metal cadmium (Cd) is a human carcinogen that inhibits DNA repair activities. We show that DNA mismatch repair (MMR)-mediated cell cycle arrest after alkylation damage is suppressed by exposure to Cd and that this effect is reversed by prei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03c791b6dc90c729dc64c4d16f3f109
https://doi.org/10.1016/j.bbrc.2004.06.102

Zobrazit plný text záznamu

Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

Autor: Sascha Emilie Liberti, Anne Charlotte Jäger, Mev Dominguez, Minna Nyström, Finn Cilius Nielsen, Anne Lützen, Pernille Mathiesen Tørring, Inge Bernstein, Lene Juel Rasmussen, Sofie Dabros Andersen, Mef Nilbert, Niels de Wind, Janus Wiese Christoffersen, Thomas van Overeem Hansen, Mark Drost

Publikováno v: Human Mutation
Human Mutation, 33(12), 1647-1655
Andersen, S D, Liberti, S E, Lützen, A, Drost, M, Bernstein, I T, Nilbert, M C, Dominguez, M, Nyström, M, Hansen, T V O, Christoffersen, J W, Jäger, A C, de Wind, N, Nielsen, F C, Tørring, P M & Rasmussen, L J 2012, ' Functional characterization of MLH1 missaense variants identified in lynch syndrome patients ', Human Mutation, vol. 33, no. 12, pp. 1647-55 . https://doi.org/10.1002/humu.22153

Germline mutations in the human DNA mismatch repair (MMR) genes MSH2 and MLH1 are associated with the inherited cancer disorder Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer or HNPCC. A proportion of MSH2 and MLH1 mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45ec51c0ba95c1890812217a13b3a03

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání