Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Sascha Drewlo"'
Publikováno v:
Cells, Vol 11, Iss 21, p 3514 (2022)
Preeclampsia (PE) is one of the most common causes of maternal-fetal morbidity and mortality world-wide. While the underlying causes of PE remain elusive, aberrant trophoblast differentiation and function are thought to cause an imbalance of secreted
Externí odkaz:
https://doaj.org/article/915b673a2f46402aab804278b52815c5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11229 (2021)
Irisin is a newly discovered exercise-mediated polypeptide hormone. Irisin levels increase during pregnancy however, women with preeclampsia (PE) have significantly lower levels of Irisin compared to women of healthy pregnancies. Even though many stu
Externí odkaz:
https://doaj.org/article/d64b147c22f74015bb6fb7ec5b36c181
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1775 (2020)
The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pr
Externí odkaz:
https://doaj.org/article/7df7e6ce96f0420f8e36475db783fdb0
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178056 (2017)
BACKGROUND:Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability. Functional SUMO family members identified in the human placenta include SUMO-1 to SUMO-3, whi
Externí odkaz:
https://doaj.org/article/a681316cfdfb41aeb8354285fcf77c8f
Autor:
Faten Shaeib, Sana N Khan, Mili Thakur, Hamid-Reza Kohan-Ghadr, Sascha Drewlo, Ghassan M Saed, Subramaniam Pennathur, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151160 (2016)
Myeloperoxidase (MPO), an abundant heme-containing enzyme present in neutrophils, monocytes, and macrophages, is produced in high levels during inflammation, and associated with poor reproductive outcomes. MPO is known to generate hypochlorous acid (
Externí odkaz:
https://doaj.org/article/e65ed48692764f0eb060f45fe889aee6
Publikováno v:
PPAR Research, Vol 2014 (2014)
Common pregnancy complications, such as severe preeclampsia and intrauterine growth restriction, disrupt pregnancy progression and impair maternal and fetal wellbeing. Placentas from such pregnancies exhibit lesions principally within the syncytiotro
Externí odkaz:
https://doaj.org/article/a65e660c19584e8daa363adc9e588a4f
Autor:
Dora Baczyk, Mark Kibschull, Britt Mellstrom, Khrystyna Levytska, Marcos Rivas, Sascha Drewlo, Stephen J Lye, Jose R Naranjo, John C P Kingdom
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51837 (2013)
The trophoblast transcription factor glial cell missing-1 (GCM1) regulates differentiation of placental cytotrophoblasts into the syncytiotrophoblast layer in contact with maternal blood. Reduced placental expression of GCM1 and abnormal syncytiotrop
Externí odkaz:
https://doaj.org/article/8a6b9d54baaa4647820709c01bb3041f
Autor:
Erica Louden, Daniel A. Rappolee, Elizabeth E. Puscheck, Sascha Drewlo, Kang Chen, Jordan Zhou, Quanwen Li, Jing Dai
Publikováno v:
Stem Cells and Development. 28:101-113
Mouse Embryonic Stem Cells (mESCs) are unique in their self-renewal and pluripotency. Hypothetically, mESCs model gestational stress effects or stresses of in vitro fertilization/assisted reproductive technologies or drug/environmental exposures that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74b41122d3f89f5db92d6bfc66a3329
https://doi.org/10.1089/scd.2018.0157
https://doi.org/10.1089/scd.2018.0157
Autor:
Ummet Abur, Ahmed Hamed Arisha, Brooke Armistead, Kenneth I. Aston, N.H. Balasinor, Barbara Benassi, Douglas T. Carrell, Shrijeet Chakraborti, Eugenia Cordelli, Kinjal Dave, Sharvari Deshpande, Sascha Drewlo, Anthony R. Gostick, Sezgin Gunes, Nojan Hafizi, Jinlian Hua, John Huntriss, Arif Hussain, Hiroki Ikeda, Emma R. James, Timothy G. Jenkins, Eugenia Johnson, Sadhana Joshi, Shama Prasada Kabekkodu, Leena Kadam, Jyotdeep Kaur, Hisato Kobayashi, Hamid-Reza Kohan-Ghadr, Takeo Kubota, Kazuki Kurimoto, Aatish Mahajan, Sweta Nair, Lakshmi Natarajan, Francesca Pacchierotti, Priyanka Parte, Aniket G. Patankar, Sahar Qazi, Beenish Rahat, Albert Salas-Huetos, Sabita N. Saldanha, Divika Sapehia, Ashok Sharma, Shefina Silas, Isha Singh, Parampal Singh, Madhumitha Kedhari Sundaram, Deepali Sundrani, Padmanaban S. Suresh, Burak Tatar, Shilpa Thakur, Sanu Thankachan, Pinar Tulay, Eva Tvrdá, Thejaswini Venkatesh, Juqing Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8799b0b7f3093cd52572e2e37390765
https://doi.org/10.1016/b978-0-12-819753-0.01002-3
https://doi.org/10.1016/b978-0-12-819753-0.01002-3
Perhaps, pregnancy is the most critical stage of human growth and development. Pathological perturbation in this period can profoundly affect the fetal wellbeing and increases susceptibility to chronic diseases later in life. The placenta is the vita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff4793f32a1f81534fae1868a9596a8
https://doi.org/10.1016/b978-0-12-819753-0.00008-8
https://doi.org/10.1016/b978-0-12-819753-0.00008-8