High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone

Autor: Lukas P.M. Kremer, Santiago Cerrizuela, Sascha Dehler, Thomas Stiehl, Jonas Weinmann, Heike Abendroth, Susanne Kleber, Alexander Laure, Jihad El Andari, Simon Anders, Anna Marciniak-Czochra, Dirk Grimm, Ana Martin-Villalba

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 33-50 (2021)

The adult mammalian brain entails a reservoir of neural stem cells (NSCs) generating glial cells and neurons. However, NSCs become increasingly quiescent with age, which hampers their regenerative capacity. New means are therefore required to genetic

Externí odkaz: https://doaj.org/article/20c78c1f028844548046b6a391c1e845

High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone

Autor: Simon Anders, Dirk Grimm, Anna Marciniak-Czochra, Jonas Weinmann, Santiago Cerrizuela, Alexander Laure, Jihad El Andari, Thomas Stiehl, Susanne Kleber, Ana Martin-Villalba, Lukas P.M. Kremer, Heike Abendroth, Sascha Dehler

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 33-50 (2021)
Mol Ther Methods Clin Dev.

The adult mammalian brain entails a reservoir of neural stem cells (NSCs) generating glial cells and neurons. However, NSCs become increasingly quiescent with age, which hampers their regenerative capacity. New means are therefore required to genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543398a42210165ab14ef12d2b91018f
http://europepmc.org/articles/PMC8427210

In vivo high-throughput screening of novel adeno-associated viral capsids targeting adult neural stem cells in the subventricular zone

Autor: Lukas P.M. Kremer, Dirk Grimm, Jihad El Andari, Thomas Stiehl, Sascha Dehler, Ana Martin-Villalba, Simon Anders, Jonas Weinmann, Santiago Cerrizuela, Anna Marciniak-Czochra, Abendroth H, Laure A, Susanne Kleber

The adult mammalian brain entails a reservoir of neural stem cells (NSCs) generating glial cells and neurons. However, NSCs become increasingly quiescent with age, which hampers their regenerative capacity. New means are therefore required to genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3251196203d277fac9c6a7d9ad20988
https://doi.org/10.1101/2021.03.05.434064

Revealing age-related changes of adult hippocampal neurogenesis using mathematical models

Autor: Anna Marciniak-Czochra, Sascha Dehler, Frederik Ziebell, Ana Martin-Villalba

Publikováno v: Development (Cambridge, England)

New neurons are continuously generated in the dentate gyrus of the adult hippocampus. This continuous supply of newborn neurons is important to modulate cognitive functions. Yet the number of newborn neurons declines with age. Increasing Wnt activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fd352d2afe12a8592ed4814f0d80c2
http://europepmc.org/articles/PMC5825879

Quantitative analysis of chromosome condensation in fission yeast

Autor: Sascha Dehler, Kota Miura, Jean-Karim Hériché, Tom Kruitwagen, Boryana Petrova, Christian H. Haering

Publikováno v: Molecular and cellular biology. 33(5)

Chromosomes undergo extensive conformational rearrangements in preparation for their segregation during cell divisions. Insights into the molecular mechanisms behind this still poorly understood condensation process require the development of new app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1727db827eaa5ebb6ca6229592aad4b
https://pubmed.ncbi.nlm.nih.gov/23263988