Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sascha Bulik"'
Autor:
Nikolaus Berndt, Sascha Bulik, Iwona Wallach, Tilo Wünsch, Matthias König, Martin Stockmann, David Meierhofer, Hermann-Georg Holzhütter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
In silico models of cells can provide insight into the causes and effects of disease states and reduce the need for in vivo studies. Here, the authors present a kinetic model of hepatocyte metabolism including energy, carbohydrate, lipid and nitrogen
Externí odkaz:
https://doaj.org/article/77be495539204df281e2112ebf72702b
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1006005 (2018)
The capacity of the liver to convert the metabolic input received from the incoming portal and arterial blood into the metabolic output of the outgoing venous blood has three major determinants: The intra-hepatic blood flow, the transport of metaboli
Externí odkaz:
https://doaj.org/article/26ef32fe25554ccfb4e6c6eaec9a2b91
Publikováno v:
International Journal of Cell Biology, Vol 2018 (2018)
Externí odkaz:
https://doaj.org/article/624dfde6448941bca9e00991906917d4
Autor:
Anja Zeigerer, Roman L. Bogorad, Kirti Sharma, Jerome Gilleron, Sarah Seifert, Susanne Sales, Nikolaus Berndt, Sascha Bulik, Giovanni Marsico, Rochelle C.J. D’Souza, Naharajan Lakshmanaperumal, Kesavan Meganathan, Karthick Natarajan, Agapios Sachinidis, Andreas Dahl, Hermann-Georg Holzhütter, Andrej Shevchenko, Matthias Mann, Victor Koteliansky, Marino Zerial
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 884-892 (2015)
The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed t
Externí odkaz:
https://doaj.org/article/baacc26e5eff48688b9e18a1e0dc126a
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118347 (2015)
Temporal changes of gene expression are a well-known regulatory feature of all cells, which is commonly perceived as a strategy to adapt the proteome to varying external conditions. However, temporal (rhythmic and non-rhythmic) changes of gene expres
Externí odkaz:
https://doaj.org/article/e450c2cdff694730b20c6380a7496853
Autor:
Hermann-Georg Holzhütter, Johan Friso Lock, Pouria Taheri, Sascha Bulik, Andrean Goede, Martin Stockmann
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70780 (2013)
Breath tests based on the administration of a (13)C-labeled drug and subsequent monitoring of (13)CO2 in the breath (quantified as DOB - delta over baseline) liberated from the drug during hepatic CPY-dependent detoxification are important tools in l
Externí odkaz:
https://doaj.org/article/76a0cfe3c10845c2b90c268cd6a5ffd1
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. In order to quantify the relation between diminished KGDHC activity and the mi
Externí odkaz:
https://doaj.org/article/9d527393e283401f89e743500c5c8d15
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002577 (2012)
Despite the crucial role of the liver in glucose homeostasis, a detailed mathematical model of human hepatic glucose metabolism is lacking so far. Here we present a detailed kinetic model of glycolysis, gluconeogenesis and glycogen metabolism in huma
Externí odkaz:
https://doaj.org/article/b093124f69794678bd135b83f07bef1e
Autor:
Christoph Gille, Christian Bölling, Andreas Hoppe, Sascha Bulik, Sabrina Hoffmann, Katrin Hübner, Anja Karlstädt, Ramanan Ganeshan, Matthias König, Kristian Rother, Michael Weidlich, Jörn Behre, Herrmann‐Georg Holzhütter
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
We present HepatoNet1, the first reconstruction of a comprehensive metabolic network of the human hepatocyte that is shown to accomplish a large canon of known metabolic liver functions. The network comprises 777 metabolites in six intracellular and
Externí odkaz:
https://doaj.org/article/b9df4590d099402e8d1e6158c0c56bdd
Autor:
Sascha Bulik, Robert Gajowski, Hermann-Georg Holzhütter, Nikolaus Berndt, David Meierhofer, Martin Stockmann, Tilo Wuensch
Publikováno v:
Archives of Toxicology
The principle of dynamic liver function breath tests is founded on the administration of a 13C-labeled drug and subsequent monitoring of 13CO2 in the breath, quantified as time series delta over natural baseline 13CO2 (DOB) liberated from the drug du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ab72df45f58a5573aaea1d502bfb01