Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Sascha Brunke"'
Autor:
Sebastian Schaefer, Raghav Vij, Jakob L. Sprague, Sophie Austermeier, Hue Dinh, Peter R. Judzewitsch, Sven Müller-Loennies, Taynara Lopes Silva, Eric Seemann, Britta Qualmann, Christian Hertweck, Kirstin Scherlach, Thomas Gutsmann, Amy K. Cain, Nathaniel Corrigan, Mark S. Gresnigt, Cyrille Boyer, Megan D. Lenardon, Sascha Brunke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract More than two million people worldwide are affected by life-threatening, invasive fungal infections annually. Candida species are the most common cause of nosocomial, invasive fungal infections and are associated with mortality rates above 4
Externí odkaz:
https://doaj.org/article/4855006eb2384c85b16fca8c8d5c88bf
Autor:
Bettina Böttcher, Sandra D. Kienast, Johannes Leufken, Cristian Eggers, Puneet Sharma, Christine M. Leufken, Bianka Morgner, Hannes C. A. Drexler, Daniela Schulz, Stefanie Allert, Ilse D. Jacobsen, Slavena Vylkova, Sebastian A. Leidel, Sascha Brunke
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTtRNA modifications play important roles in maintaining translation accuracy in all domains of life. Disruptions in the tRNA modification machinery, especially of the anticodon stem loop, can be lethal for many bacteria and lead to a broad ran
Externí odkaz:
https://doaj.org/article/a114f64854bb4cc889551a3b09495768
Autor:
Bastian Seelbinder, Zoltan Lohinai, Ruben Vazquez-Uribe, Sascha Brunke, Xiuqiang Chen, Mohammad Mirhakkak, Silvia Lopez-Escalera, Balazs Dome, Zsolt Megyesfalvi, Judit Berta, Gabriella Galffy, Edit Dulka, Anja Wellejus, Glen J. Weiss, Michael Bauer, Bernhard Hube, Morten O. A. Sommer, Gianni Panagiotou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Candida species overgrowth in the human gut is considered a prerequisite for invasive candidiasis, but our understanding of gut bacteria promoting or restricting this overgrowth is still limited. By integrating cross-sectional mycobiome and
Externí odkaz:
https://doaj.org/article/995d19354eac486bafefacd3d3f6112b
Autor:
Stefanie Allert, Daniela Schulz, Philipp Kämmer, Peter Großmann, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Sascha Brunke, Bernhard Hube
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 191-214 (2022)
Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C. auris recently emerged as a new species ca
Externí odkaz:
https://doaj.org/article/635a35659e774cd6ad475056a5cb80fd
Autor:
Carsten Schwarz, Patience Eschenhagen, Henrijette Schmidt, Thordis Hohnstein, Christina Iwert, Claudia Grehn, Jobst Roehmel, Eva Steinke, Mirjam Stahl, Laura Lozza, Ekaterina Tikhonova, Elisa Rosati, Ulrik Stervbo, Nina Babel, Jochen G. Mainz, Hilmar Wisplinghoff, Frank Ebel, Lei-Jie Jia, Matthew G. Blango, Peter Hortschansky, Sascha Brunke, Bernhard Hube, Axel A. Brakhage, Olaf Kniemeyer, Alexander Scheffold, Petra Bacher
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
BACKGROUND The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus–specific Th cells in pwCF and their cont
Externí odkaz:
https://doaj.org/article/952a35bb46204b4d99016140937e7c30
Autor:
Mieke Van Ende, Bea Timmermans, Giel Vanreppelen, Sofía Siscar-Lewin, Daniel Fischer, Stefanie Wijnants, Celia Lobo Romero, Saleh Yazdani, Ona Rogiers, Liesbeth Demuyser, Griet Van Zeebroeck, Yuke Cen, Karl Kuchler, Sascha Brunke, Patrick Van Dijck
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 329-345 (2021)
Candida glabrata is an opportunistic human fungal pathogen and is frequently present in the human microbiome. It has a high relative resistance to environmental stresses and several antifungal drugs. An important component involved in microbial stres
Externí odkaz:
https://doaj.org/article/6d406c2f40a54bcdb3449075a5e053b3
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1244-1252 (2021)
Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever-inc
Externí odkaz:
https://doaj.org/article/8d51ce20519547a2a51e272a25bff35a
Autor:
Bastian Seelbinder, Jiarui Chen, Sascha Brunke, Ruben Vazquez-Uribe, Rakesh Santhaman, Anne-Christin Meyer, Felipe Senne de Oliveira Lino, Ka-Fai Chan, Daniel Loos, Lejla Imamovic, Chi-Ching Tsang, Rex Pui-kin Lam, Siddharth Sridhar, Kang Kang, Bernhard Hube, Patrick Chiu-yat Woo, Morten Otto Alexander Sommer, Gianni Panagiotou
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Background Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization
Externí odkaz:
https://doaj.org/article/094b3dea44204e7f8f97543a71e9fbb1
Autor:
Selene Mogavero, Sarah Höfs, Alexa N. Lauer, Rita Müller, Sascha Brunke, Stefanie Allert, Franziska Gerwien, Sabrina Groth, Edward Dolk, Duncan Wilson, Thomas Gutsmann, Bernhard Hube
Publikováno v:
Toxins, Vol 14, Iss 12, p 874 (2022)
Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C. albicans has also long been known to be hemo
Externí odkaz:
https://doaj.org/article/fe0ef4d748e54acaa7575ef1142cb32f
Autor:
Sofía Siscar-Lewin, Toni Gabaldón, Alexander M. Aldejohann, Oliver Kurzai, Bernhard Hube, Sascha Brunke
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Candida glabrataCandida albicansCandida
Externí odkaz:
https://doaj.org/article/d91d5217707f4e55a587fdd660c439e8