Zobrazeno 1 - 10 of 86 pro vyhledávání: '"Sascha Beneke"'
1
Physiological oxygen and co-culture with human fibroblasts facilitate in vivo-like properties in human renal proximal tubular epithelial cells
Autor: Felicitas Piossek, Sascha Beneke, Nadja Schlichenmaier, Goran Mucic, Sabine Drewitz, Daniel R. Dietrich
Publikováno v: Chemico-biological interactions. 361
Reliable prediction of compound mediated nephrotoxicity in humans is still unsatisfactory irrespective of the recent advancements in in silico, in vitro and in vivo models. Therefore, current in vitro approaches need refinement to better match the hu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0698fb6b76d9213610cf4c9037a3dd
https://pubmed.ncbi.nlm.nih.gov/35533734
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2
Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models
Autor: Heinke Bastek, Sascha Beneke, Aswin Mangerich, Kerstin Stemmer, Tabea Zubel, Daniel R. Dietrich
Publikováno v: Toxicology 420, 29-38 (2019)
Aristolochic acid (AA) dependent human nephropathy results either from environmental exposure to Aristolochiaceae plant subspecies or their use in traditional phytotherapy. The toxic components are structurally related nitrophenanthrene carboxylic ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b489d4cbfbcbb5b458cb01b3f8b73886
https://doi.org/10.1016/j.tox.2019.03.013
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3
Mitochondria are devoid of poly(ADP-ribose)polymerase-1, but harbor its product oligo(ADP-ribose)
Autor: Christian Blenn, Alexander Bürkle, Sascha Beneke, Julia Köritzer
There are conflicting data about localization of poly(ADP-ribose)polymerase-1 and its product poly(ADP-ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical and cell biological methods the potential presence of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8bfc5fbbb491dc476cad9432250ac9
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4
Akademický článek
Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation.
Autor: Sascha Beneke, Kirstin Meyer, Anja Holtz, Katharina Hüttner, Alexander Bürkle
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32914 (2012)
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which is followed by isolation of specific protein-DNA complexes and subsequent PCR testing, to analyze DNA-protein interactions. Poly(ADP-ribosyl)ation, a
Externí odkaz: https://doaj.org/article/434011c830fc43f29f6739bb2eedc31e
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6
The NAD+ precursor nicotinic acid improves genomic integrity in human peripheral blood mononuclear cells after X-irradiation
Autor: Alexander Bürkle, Sascha Beneke, Kathrin Weidele
NAD+ is an essential cofactor for enzymes catalyzing redox-reactions as well as an electron carrier in energy metabolism. Aside from this, NAD+ consuming enzymes like poly(ADP-ribose) polymerases and sirtuins are important regulators involved in chro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ce9945270613b91f15663d66601dee
https://publica.fraunhofer.de/handle/publica/248339
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7
Poly( ADP ‐ribose)‐mediated interplay of XPA and PARP 1 leads to reciprocal regulation of protein function
Autor: Sascha Beneke, Aswin Mangerich, Sebastian Veith, Martin Scheffner, Jan M. F. Fischer, Arthur Fischbach, Elisa Ferrando-May, Alexander Bürkle, Daniel Gebhard, Jörg Bergemann, Alfred Leitenstorfer, Oliver Popp
Publikováno v: The Febs Journal
Poly(ADP-ribose) (PAR) is a complex and reversible post-translational modification that controls protein function and localization through covalent modification of, or noncovalent binding to target proteins. Previously, we and others characterized th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b773c5f99de49e6a5c93dff93a1070
https://doi.org/10.1111/febs.12885
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8
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells
Autor: Christopher Vogel, Christina Renner, Sascha Beneke, Aswin Mangerich, Marjolijn C.J. Jongmans, Jan M. F. Fischer, Anna Stier, Sebastian Veith, Elisa Ferrando-May, Alexander Bürkle, Magdalena Ganz, Janine Demgenski, Roland P. Kuiper, Arthur Fischbach, Michael Schmalz, Stefanie Buerger, Eva Gwosch, Lisa Rank, Marcus Groettrup, Tabea Zubel
Publikováno v: Nucleic Acids Research, 44(21), 10386–10405. Oxford University Press
Nucleic Acids Research, 44, 10386-10405
Nucleic Acids Research, 44, 21, pp. 10386-10405
Nucleic Acids Research
Contains fulltext : 171327.pdf (Publisher’s version ) (Open Access) Genotoxic stress activates PARP1, resulting in the post-translational modification of proteins with poly(ADP-ribose) (PAR). We genetically deleted PARP1 in one of the most widely u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67866fcd8e5365529f3ebc349b62196f
https://dspace.library.uu.nl/handle/1874/341968
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10
Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation
Autor: Sarah Wallrodt, Elisa Ferrando-May, Annette Buntz, Michael Schmalz, Sascha Beneke, Andreas Zumbusch, Andreas Marx, Eva Gwosch
Poly(ADP-ribos)ylation (PARylation) is an important posttranslational protein modification, and is involved in major cellular processes such as gene regulation and DNA repair. Its dysregulation has been linked to several diseases, including cancer. D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309bcb73ed6159bf6974230f9c360fb5
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