Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Sascha, Sauer"'
Autor:
Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga-Franze, Nikita A. Verheyden, Sakhila Ghimire, Elisabeth Meedt, Denise Haslinger, Sabine Harenkamp, Daniel Staudenraus, Sascha Sauer, Andreas Kreft, Ralf Schubert, Michael Lohoff, Andreas Krueger, Halvard Bonig, Andreas G. Chiocchetti, Robert Zeiser, Ernst Holler, Evelyn Ullrich
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTInterferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine zipper transcription factor, ATF-like (BATF), depletion of which in CD4+ T cells abr
Externí odkaz:
https://doaj.org/article/0e061017555b4bc0b1aa91d36567a9dd
Autor:
Barbara Altieri, A. Kerim Secener, Somesh Sai, Cornelius Fischer, Silviu Sbiera, Panagiota Arampatzi, Stefan Kircher, Sabine Herterich, Laura‐Sophie Landwehr, Sarah N. Vitcetz, Caroline Braeuning, Martin Fassnacht, Cristina L. Ronchi, Sascha Sauer
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 8, Pp n/a-n/a (2024)
Abstract The human adrenal gland is a complex endocrine tissue. Studies on adrenal renewal have been limited to animal models or human foetuses. Enhancing our understanding of adult human adrenal homeostasis is crucial for gaining insights into the p
Externí odkaz:
https://doaj.org/article/4ae5924c19d04e65b118283ca507f2e1
Autor:
Kiara Freitag, Pascale Eede, Andranik Ivanov, Nele Sterczyk, Shirin Schneeberger, Tatiana Borodina, Sascha Sauer, Dieter Beule, Frank L. Heppner
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Functional and transcriptomic comparison of primary neonatal, adult and ESC-derived astrocytes reveals major variations, highlighting the importance for an informed choice of astrocyte origin for research questions.
Externí odkaz:
https://doaj.org/article/05135891432948ffa78bb4d70ca947ef
Autor:
Julia Kazmierski, Kirstin Friedmann, Dylan Postmus, Jackson Emanuel, Cornelius Fischer, Jenny Jansen, Anja Richter, Laure Bosquillon de Jarcy, Christiane Schüler, Madlen Sohn, Sascha Sauer, Christian Drosten, Antoine‐Emmanuel Saliba, Leif Erik Sander, Marcel A Müller, Daniela Niemeyer, Christine Goffinet
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 8, Pp 1-16 (2022)
Abstract Cell‐intrinsic responses mounted in PBMCs during mild and severe COVID‐19 differ quantitatively and qualitatively. Whether they are triggered by signals emitted by productively infected cells of the respiratory tract or result from physi
Externí odkaz:
https://doaj.org/article/bd2eb001419145ec893ee0b1a1a9d093
Autor:
Marta Kapalczynska, Manqiang Lin, Jeroen Maertzdorf, Julian Heuberger, Stefanie Muellerke, Xiangsheng Zuo, Ramon Vidal, Imad Shureiqi, Anne-Sophie Fischer, Sascha Sauer, Hilmar Berger, Evelyn Kidess, Hans-Joachim Mollenkopf, Frank Tacke, Thomas F. Meyer, Michael Sigal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Helicobacter pylori causes gastric inflammation, gland hyperplasia and is linked to gastric cancer. Here the authors identify a BMP feedback loop between the stomach epithelium and surrounding stroma that controls gland homeostasis and demonstrate it
Externí odkaz:
https://doaj.org/article/d77fc1814d4b4a59a4f1c341261c1b01
Autor:
Armin Rehm, Anthea Wirges, Dana Hoser, Cornelius Fischer, Stefanie Herda, Kerstin Gerlach, Sascha Sauer, Gerald Willimsky, Uta E. Höpken
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Insight into processes that determine CD8+ T cell memory formation has been obtained from infection models. These models are biased toward an inflammatory milieu and often use high-avidity CD8+ T cells in adoptive-transfer procedures. It is unclear w
Externí odkaz:
https://doaj.org/article/4452480c9d30462d815ab05dab0318f8
Autor:
Johanna Grinat, Julian Heuberger, Ramon Oliveira Vidal, Neha Goveas, Frauke Kosel, Antoni Berenguer-Llergo, Andrea Kranz, Annika Wulf-Goldenberg, Diana Behrens, Bálint Melcher, Sascha Sauer, Michael Vieth, Eduard Batlle, A. Francis Stewart, Walter Birchmeier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.
Externí odkaz:
https://doaj.org/article/3b5f2ff3d1124d7c81f483c2f20a5a38
Autor:
Alina Klems, Jos van Rijssel, Anne S. Ramms, Raphael Wild, Julia Hammer, Melanie Merkel, Laura Derenbach, Laetitia Préau, Rabea Hinkel, Irina Suarez-Martinez, Stefan Schulte-Merker, Ramon Vidal, Sascha Sauer, Riikka Kivelä, Kari Alitalo, Christian Kupatt, Jaap D. van Buul, Ferdinand le Noble
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independe
Externí odkaz:
https://doaj.org/article/766d4ed327d94a5ba84fee477abb7f31
Autor:
Verena Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Perez Hernandez, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent Magrini, Amy Ly, Jason Walker, Elaine Mardis, Philipp Mertins, Sascha Sauer, Helmut Kettenmann, David H. Gutmann
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-4 (2020)
The original publication of this article [1] contained 3 minor errors in Figs. 1, 3 and 5. In this correction article the updated figures are published. The figure captions describe the updated information in these figures.
Externí odkaz:
https://doaj.org/article/654d2c78a6024ca38b233dd357d32db9
Autor:
Andreas Marg, Helena Escobar, Nikos Karaiskos, Stefanie A. Grunwald, Eric Metzler, Janine Kieshauer, Sascha Sauer, Diana Pasemann, Edoardo Malfatti, Dominique Mompoint, Susanna Quijano-Roy, Anastasiya Boltengagen, Joanna Schneider, Markus Schülke, Séverine Kunz, Robert Carlier, Carmen Birchmeier, Helge Amthor, Andreas Spuler, Christine Kocks, Nikolaus Rajewsky, Simone Spuler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Skeletal muscle stem cells express the transcription factor Pax7. Here, the authors isolate, from human muscle, cells that are positive for the endothelial marker CLEC14A and show that despite not expressing pax7, these cells regenerate muscle and co
Externí odkaz:
https://doaj.org/article/ce96cb57dae14384b0b97d2a3e6fda84