Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sascha, Rahn"'
Autor:
Tina Daunke, Silje Beckinger, Sascha Rahn, Sandra Krüger, Steffen Heckl, Heiner Schäfer, Daniela Wesch, Christian Pilarsky, Markus Eckstein, Arndt Hartmann, Christoph Röcken, Anna Maxi Wandmacher, Susanne Sebens
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmune checkpoint inhibitors (ICI), e.g., targeting programmed cell death protein 1-ligand 1 (PD-L1) or its receptor PD-1, have markedly improved the therapy of many cancers but so far failed in pancreatic ductal adenocarcinoma (PDAC). Ma
Externí odkaz:
https://doaj.org/article/f2babd76fb144183893834bce80fb625
Autor:
Silje Beckinger, Tina Daunke, Leon Aldag, Sandra Krüger, Steffen Heckl, Daniela Wesch, Heiner Schäfer, Christoph Röcken, Sascha Rahn, Susanne Sebens
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionPancreatic ductal adenocarcinoma (PDAC) represents the 4th most common cause of cancer-related deaths in Western countries. Most patients are diagnosed at advanced stages, often already with metastases. The main site of metastasis is the
Externí odkaz:
https://doaj.org/article/817692eed56944a0ad4bfc2a431adf27
Autor:
Frederik Walter, Elsa Winter, Sascha Rahn, Judith Heidland, Saskia Meier, Anna-Maria Struzek, Marcus Lettau, Lisa-Marie Philipp, Silje Beckinger, Lilli Otto, Julia Luisa Möller, Ole Helm, Daniela Wesch, Regina Scherließ, Susanne Sebens
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239369 (2020)
Cancer vaccinations sensitize the immune system to recognize tumor-specific antigens de novo or boosting preexisting immune responses. Dendritic cells (DCs) are regarded as the most potent antigen presenting cells (APCs) for induction of (cancer) ant
Externí odkaz:
https://doaj.org/article/6e7ed2b478ca4a4f88e6a1f69cde7082
Autor:
Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzold
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214847 (2019)
Due to their ability to preferentially induce cell death in tumor cells, while sparing healthy cells, TNF-related apoptosis-inducing ligand (TRAIL) and agonistic anti-TRAIL-R1 or anti-TRAIL-R2-specific antibodies are under clinical investigations for
Externí odkaz:
https://doaj.org/article/b399ac7566e0450e9157f35b7a9e1750
Autor:
Lilli Otto, Sascha Rahn, Tina Daunke, Frederik Walter, Elsa Winter, Julia Luisa Möller, Stefan Rose-John, Daniela Wesch, Heiner Schäfer, Susanne Sebens
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5086 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive solid malignancies with a poor prognosis. Obesity and type 2 diabetes mellitus (T2DM) are two major risk factors linked to the development and progression of PDAC, both often
Externí odkaz:
https://doaj.org/article/ddf822b0cf9e47cb90ed589c37475007
Autor:
Anna Otte, Erwin F. Wagner, Christoph Becker-Pauly, Franka Scharfenberg, Marion Mengel, Sascha Rahn, F. Thomas Wunderlich, Florian Peters, Ronald Naumann, Andreas Tholey, Tomas Koudelka, Michael Haase
Publikováno v:
Matrix Biology. 102:37-69
Dysregulation of proteolytic enzymes has huge impact on epidermal homeostasis, which can result in severe pathological conditions such as fibrosis or Netherton syndrome. The metalloprotease meprin β was found to be upregulated in hyperproliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4ce3cb1ba1b2d5237e56f7375d3b3e
https://doi.org/10.1016/j.matbio.2021.08.002
https://doi.org/10.1016/j.matbio.2021.08.002
Autor:
Sascha Rahn, Christoph Becker-Pauly
Publikováno v:
FEBS lettersReferences. 596(5)
Systemic inflammatory disorders (SIDs) comprise a broad range of diseases characterized by dysregulated excessive innate immune responses. Severe forms of SIDs can lead to organ failure and death, and their increasing incidence represents a major iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612849235cc24dc539a5b0fc1735877f
https://pubmed.ncbi.nlm.nih.gov/34762736
https://pubmed.ncbi.nlm.nih.gov/34762736
Autor:
Simon Stegner, Dieter Saur, Johannes Zimmermann, Lauritz Miarka, Sascha Schäuble, Hendrike Knaack, Christoph Kaleta, Fabrice Viol, Daniela Esser, Robert Häsler, Heiner Schäfer, Georgios Marinos, Jann Buttlar, Sascha Rahn, Lennart Lenk, Peter Großmann, Wolfgang Mikulits, Susanne Sebens, Alexander Fabian
Publikováno v:
Cancer Letters
Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed when liver metastases already emerged. We recently demonstrated that hepatic stromal cells determine the dormancy status along with cancer stem cell (CSC) properties of pancreatic ductal e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7be10fa4aa014a5f30b7d9ecb971f5
https://doi.org/10.1016/j.canlet.2019.03.039
https://doi.org/10.1016/j.canlet.2019.03.039
Autor:
Sebens, Lilli Otto, Sascha Rahn, Tina Daunke, Frederik Walter, Elsa Winter, Julia Luisa Möller, Stefan Rose-John, Daniela Wesch, Heiner Schäfer, Susanne
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 10; Pages: 5086
Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive solid malignancies with a poor prognosis. Obesity and type 2 diabetes mellitus (T2DM) are two major risk factors linked to the development and progression of PDAC, both often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::99f1bd976b857756b5de7a07eadb8e06
Autor:
Christoph Becker-Pauly, Andreas Tholey, Florian Peters, F. Thomas Wunderlich, Michael Haase, Ronald Naumann, Anna Otte, Tomas Koudelka, Marion Mengel, Sascha Rahn, Erwin F. Wagner, Franka Scharfenberg
Publikováno v:
Matrix Biology. 105:144
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59db87ddccb8cc4695b0284878ea996b
https://doi.org/10.1016/j.matbio.2021.10.003
https://doi.org/10.1016/j.matbio.2021.10.003