Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Sascha, Martens"'
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113583- (2023)
Summary: Selective autophagy mediates the removal of harmful material from the cytoplasm. This cargo material is selected by cargo receptors, which orchestrate its sequestration within double-membrane autophagosomes and subsequent lysosomal degradati
Externí odkaz:
https://doaj.org/article/ab634fcf79e74db9afc6897c181e658f
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 161-164 (2022)
Externí odkaz:
https://doaj.org/article/e3b6119c5e1e46689e0054c9850deec8
Autor:
Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig, Sascha Martens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin c
Externí odkaz:
https://doaj.org/article/4db780a5a06e48a0bc6214ed5a5ead08
Autor:
Madlen Stephani, Lorenzo Picchianti, Alexander Gajic, Rebecca Beveridge, Emilio Skarwan, Victor Sanchez de Medina Hernandez, Azadeh Mohseni, Marion Clavel, Yonglun Zeng, Christin Naumann, Mateusz Matuszkiewicz, Eleonora Turco, Christian Loefke, Baiying Li, Gerhard Dürnberger, Michael Schutzbier, Hsiao Tieh Chen, Alibek Abdrakhmanov, Adriana Savova, Khong-Sam Chia, Armin Djamei, Irene Schaffner, Steffen Abel, Liwen Jiang, Karl Mechtler, Fumiyo Ikeda, Sascha Martens, Tim Clausen, Yasin Dagdas
Publikováno v:
eLife, Vol 9 (2020)
Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy (termed as ER-phagy) has emerged as a major quality control mechanism. However
Externí odkaz:
https://doaj.org/article/1d708f6cc8c24774a8944d97003c4e5c
Autor:
Jana Sánchez-Wandelmer, Franziska Kriegenburg, Sabrina Rohringer, Martina Schuschnig, Rubén Gómez-Sánchez, Bettina Zens, Susana Abreu, Ralph Hardenberg, David Hollenstein, Jieqiong Gao, Christian Ungermann, Sascha Martens, Claudine Kraft, Fulvio Reggiori
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4
Externí odkaz:
https://doaj.org/article/0d25d8e1163b4f90ae02c9c439b13fba
Publikováno v:
Journal of Cell Science. 136
Cells keep their proteome functional by the action of the proteostasis network, composed of the chaperones, the ubiquitin-proteasome system and autophagy. The decline of this network results in the accumulation of protein aggregates and is associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b07a0f615155675280eec1ae7999a7ee
https://doi.org/10.1242/jcs.260888
https://doi.org/10.1242/jcs.260888
Autor:
Lorenzo Picchianti, Víctor Sánchez de Medina Hernández, Ni Zhan, Nicholas AT Irwin, Roan Groh, Madlen Stephani, Harald Hornegger, Rebecca Beveridge, Justyna Sawa‐Makarska, Thomas Lendl, Nenad Grujic, Christin Naumann, Sascha Martens, Thomas A Richards, Tim Clausen, Silvia Ramundo, G Elif Karagöz, Yasin Dagdas
Publikováno v:
The EMBO Journal. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f5020dbcf388ba3dd00f073772fbb2
https://doi.org/10.15252/embj.2022112053
https://doi.org/10.15252/embj.2022112053
Autor:
Marina N. Iriondo, Asier Etxaniz, Yaiza R. Varela, Uxue Ballesteros, Melisa Lázaro, Mikel Valle, Dorotea Fracchiolla, Sascha Martens, L. Ruth Montes, Félix M. Goñi, Alicia Alonso
Publikováno v:
Cellular and Molecular Life Sciences. 80
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ATG12–ATG5-ATG16L1 or E3-like c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe3c3a9bf68b3713bfda0fb20744fc
https://doi.org/10.1007/s00018-023-04704-z
https://doi.org/10.1007/s00018-023-04704-z
Autor:
Steve Catarino, Teresa M Ribeiro-Rodrigues, Rita Sá Ferreira, José Ramalho, Christine Abert, Sascha Martens, Henrique Girão
Publikováno v:
Cells, Vol 9, Iss 4, p 902 (2020)
Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the
Externí odkaz:
https://doaj.org/article/2591137a158249adad3f3ea4c2f3dbe6
Autor:
Marina N. Iriondo, Asier Etxaniz, Yaiza R. Varela, Uxue Ballesteros, Melisa Lázaro, Mikel Valle, Dorotea Fracchiolla, Sascha Martens, L. Ruth Montes, Felix M Goni, Alicia Alonso
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ATG12–ATG5-ATG16L1 (E3) complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd5d35e52dd7a1600133a626d9686e5
https://doi.org/10.21203/rs.3.rs-1925210/v1
https://doi.org/10.21203/rs.3.rs-1925210/v1
