A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism.

Autor: Nikolaus Berndt, Marius Stefan Horger, Sascha Bulik, Hermann-Georg Holzhütter

Publikováno v: PLoS Computational Biology, Vol 14, Iss 2, p e1006005 (2018)

The capacity of the liver to convert the metabolic input received from the incoming portal and arterial blood into the metabolic output of the outgoing venous blood has three major determinants: The intra-hepatic blood flow, the transport of metaboli

Externí odkaz: https://doaj.org/article/26ef32fe25554ccfb4e6c6eaec9a2b91

Regulation of Liver Metabolism by the Endosomal GTPase Rab5

Autor: Anja Zeigerer, Roman L. Bogorad, Kirti Sharma, Jerome Gilleron, Sarah Seifert, Susanne Sales, Nikolaus Berndt, Sascha Bulik, Giovanni Marsico, Rochelle C.J. D’Souza, Naharajan Lakshmanaperumal, Kesavan Meganathan, Karthick Natarajan, Agapios Sachinidis, Andreas Dahl, Hermann-Georg Holzhütter, Andrej Shevchenko, Matthias Mann, Victor Koteliansky, Marino Zerial

Publikováno v: Cell Reports, Vol 11, Iss 6, Pp 884-892 (2015)

The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed t

Externí odkaz: https://doaj.org/article/baacc26e5eff48688b9e18a1e0dc126a

The stability and robustness of metabolic states: identifying stabilizing sites in metabolic networks

Autor: Sergio Grimbs, Joachim Selbig, Sascha Bulik, Hermann‐Georg Holzhütter, Ralf Steuer

Publikováno v: Molecular Systems Biology, Vol 3, Iss 1, Pp 1-12 (2007)

Abstract The dynamic behavior of metabolic networks is governed by numerous regulatory mechanisms, such as reversible phosphorylation, binding of allosteric effectors or temporal gene expression, by which the activity of the participating enzymes can

Externí odkaz: https://doaj.org/article/ac38940aa52f429b88779d93fcf41110

Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test.

Autor: Hermann-Georg Holzhütter, Johan Friso Lock, Pouria Taheri, Sascha Bulik, Andrean Goede, Martin Stockmann

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e70780 (2013)

Breath tests based on the administration of a (13)C-labeled drug and subsequent monitoring of (13)CO2 in the breath (quantified as DOB - delta over baseline) liberated from the drug during hepatic CPY-dependent detoxification are important tools in l

Externí odkaz: https://doaj.org/article/76a0cfe3c10845c2b90c268cd6a5ffd1

Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer

Autor: Sascha Bulik, Thorsten Cramer, Athanassios Fragoulis, Stefan Kempa, Nikolaus Berndt, Guido Mastrobuoni, Hermann-Georg Holzhütter, Steven W.M. Olde Damink, Aurelien Dugourd, Olga Vvedenskaya, Matthias Pietzke, Antje Egners, Chris Bielow, Rob J.J. van Gassel, Julio Saez-Rodriguez, Merve Erdem

Publikováno v: British journal of cancer : BJC 122(2), 233-244 (2020). doi:10.1038/s41416-019-0659-3 special issue: "Cancer Metabolism"
British Journal of Cancer
British Journal of Cancer, 122(2), 233-244. Nature Publishing Group

Background Metabolic alterations can serve as targets for diagnosis and cancer therapy. Due to the highly complex regulation of cellular metabolism, definite identification of metabolic pathway alterations remains challenging and requires sophisticat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78df8ae591f16ec46b90fe1e4ef8ce05