Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sasa Koncarevic"'
Autor:
Victoria Anne Brentville, Peter Symonds, JiaXin Chua, Anne Skinner, Ian Daniels, Katherine Wendy Cook, Sasa Koncarevic, Roxana Martinez-Pinna, Sabaria Shah, Ruhul Hasan Choudhury, Poonam Vaghela, Daisy Weston, Abdullah Al-Omari, James Davis, Lindy G. Durrant
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionPost translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during cellular stress (autophagy) which pe
Externí odkaz:
https://doaj.org/article/28d852b1f8be4f17aed578ed2a659ca7
Autor:
Gino L. Turra, Linda Liedgens, Frederik Sommer, Luzia Schneider, David Zimmer, Jordi Vilurbina Perez, Sasa Koncarevic, Michael Schroda, Timo Mühlhaus, Marcel Deponte
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Import and oxidative folding of proteins in the mitochondrial intermembrane space differ among eukaryotic lineages. While opisthokonts such as yeast rely on the receptor and oxidoreductase Mia40 in combination with the Mia40:cytochrome c oxi
Externí odkaz:
https://doaj.org/article/a4dcdabe3efe423aafcd59937b867fce
Autor:
David Britton, Yoh Zen, Alberto Quaglia, Stefan Selzer, Vikram Mitra, Christopher Löβner, Stephan Jung, Gitte Böhm, Peter Schmid, Petra Prefot, Claudia Hoehle, Sasa Koncarevic, Julia Gee, Robert Nicholson, Malcolm Ward, Leandro Castellano, Justin Stebbing, Hans Dieter Zucht, Debashis Sarker, Nigel Heaton, Ian Pike
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90948 (2014)
LC-MS/MS phospho-proteomics is an essential technology to help unravel the complex molecular events that lead to and propagate cancer. We have developed a global phospho-proteomic workflow to determine activity of signaling pathways and drug targets
Externí odkaz:
https://doaj.org/article/edd0b90887b84bcd9a1301916291bac8
Autor:
Nicole Sturm, Esther Jortzik, Boniface M Mailu, Sasa Koncarevic, Marcel Deponte, Karl Forchhammer, Stefan Rahlfs, Katja Becker
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000383 (2009)
The malarial parasite Plasmodium falciparum possesses a functional thioredoxin and glutathione system comprising the dithiol-containing redox proteins thioredoxin (Trx) and glutaredoxin (Grx), as well as plasmoredoxin (Plrx), which is exclusively fou
Externí odkaz:
https://doaj.org/article/b8d1cecfc6aa401191544c419bcd4697
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4098 (2008)
Proteome studies contribute markedly to our understanding of parasite biology, host-parasite interactions, and mechanisms of drug action. For most antimalarial drugs neither mode of action nor mechanisms of resistance development are fully elucidated
Externí odkaz:
https://doaj.org/article/5f389c738b6e4a1fa5a4e9afb015e6c9
Autor:
Stephan Jung, Dennis Friedel, Ines Heiland, Tobias Bausbacher, Christiane A. Opitz, Stefan Selzer, Ian Pike, Andreas von Deimling, Antje Wick, Karsten Kuhn, Suraj Sharma, Verena Panitz, Irada Pflüger, Sandra Schulz, Wolfgang Wick, Philipp Vollmuth, Sasa Koncarevic, Philipp Sievers, Saskia Trump, Stefan Schmidt, Carsten Hopf, Felix Sahm, Peter Schulz-Knappe, Michael Platten, V. M. Farztdinov, Pauline Pfänder, Ina Jürgenson, Ahmed Sadik
Publikováno v:
Theranostics
Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better underst
Autor:
Stephan Jung, Ian Pike, Stefan Selzer, Petra Penning, Karsten Kuhn, Claudia Höhle, Harald Legner, Stefan Kienle, Andrew J. Thompson, Roxana Martinez-Pinna, Sasa Koncarevic, Peter Schmid, Antje Berfelde, V. M. Farztdinov, Gitte Böhm, Nikolai Wölmer
Publikováno v:
Analytical Chemistry. 91:15941-15950
The design and synthesis of a proline-based reporter isobaric Tandem Mass Tag structure (TMTpro) is presented. An analysis is made of the performance of the new TMTpro tags in comparison with the current commercially available dimethylpiperidine-repo
Autor:
Stephan Jung, Ian Pike, Irene Zubiri, Claire Russell, Malcolm Ward, Vittoria Lombardi, Sasa Koncarevic, Michael Bremang, Emanuela Leoni, Andrea Malaspina, Rocco Adiutori, Ching-Hua Lu, Vikram Mitra
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Scientific Reports
The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment response has hampered the development of new therapies for amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disorder with a
Autor:
Michael Bremang, Irene Zubiri, Vittoria Lombardi, Sasa Koncarevic, Emanuela Leoni, Ian Pike, Andrea Malaspina, Rocco Adiutori, Malcolm Ward, Claire Russell, Ching-Hua Lu, Vikram Mitra, Stephan Jung
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publikováno v:
Journal of Alzheimer's Disease. 41:345-364
The ability to detect and diagnose Alzheimer's disease (AD) early is an ever pressing issue, and the development of markers of disease progression that are able to distinguish AD patients from normal aging and patients with alternative forms of demen