Výsledky vyhledávání - "Sarvetnick, N"

Islet Regeneration in IFNµ Transgenic Mice

Autor: Sarvetnick N, Jones Em

Publikováno v: Hormone and Metabolic Research. 29:308-310

The adult pancreas is a developmentally stable organ with limited mitotic activity. This minimal mitotic activity proves critical in insulin-dependent diabetes mellitus (IDDM) since the pathogenesis is characterized by a selective and permanent destr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d13878cd7f18324ae5a1079ac8229e85
https://doi.org/10.1055/s-2007-979041

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Leptin accelerates onset and progression of autoimmune diabetes in the nonobese diabetic (NOD) mouse

Autor: Matarese G. 2, Sanna V. 2, Lechler R.I. 3, Sarvetnick N. 4, Fontana S. 2, Zappacosta S. 1, La Cava A. 4

Publikováno v: Diabetes (N.Y.N.Y.) 51 (2002): 1356–1361.
info:cnr-pdr/source/autori:Matarese G. 2, Sanna V. 2, Lechler R.I. 3, Sarvetnick N. 4, Fontana S. 2, Zappacosta S. 1, La Cava A. 4/titolo:Leptin accelerates onset and progression of autoimmune diabetes in the nonobese diabetic (NOD) mouse./doi:/rivista:Diabetes (N.Y.N.Y.)/anno:2002/pagina_da:1356/pagina_a:1361/intervallo_pagine:1356–1361/volume:51

We have recently shown that leptin, the product of the obese gene, can directly influence T-cell function. In the work presented here, we explored the role of leptin in the development of spontaneous autoimmunity in the nonobese diabetic (NOD) mouse,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::7e54443108a1dd7e26f4da033f023ff7
https://publications.cnr.it/doc/20901

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Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus

Autor: Ht, Kreuwel, Dj, Morgan, Krahl T, Ko A, Sarvetnick N, Linda Sherman

Publikováno v: Europe PubMed Central

CD8+ cytotoxic T cells play a critical role in initiating insulin-dependent diabetes mellitus. The relative contribution of each of the major cytotoxic pathways, perforin/granzyme and Fas/Fas ligand (FasL), in the induction of autoimmune diabetes rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::103bb5013ab19d9f28a9d0660180744c
https://pubmed.ncbi.nlm.nih.gov/10510373

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Postnatal anti-interferon-gamma treatment prevents pancreatic inflammation in transgenic mice with beta-cell expression of interferon-gamma

Autor: Wogensen, L, Molony, L, Gu, D, Krahl, T, Zhu, S, Sarvetnick, N

Publikováno v: Wogensen, L, Molony, L, Gu, D, Krahl, T, Zhu, S & Sarvetnick, N 1994, ' Postnatal anti-interferon-gamma treatment prevents pancreatic inflammation in transgenic mice with beta-cell expression of interferon-gamma ', Journal of interferon research, vol. 14, no. 3, pp. 111-6 .

beta-Cell-targeted expression of interferon-gamma (IFN-gamma) leads to pancreatitis and immune sensitization to beta-cells. This transgenic model is used to explore the possible role of locally produced IFN-gamma in loss of tolerance to beta-cell-spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::b365b5da95afd9c7c60eda53cec89cf1
https://pure.au.dk/portal/da/publications/postnatal-antiinterferongamma-treatment-prevents-pancreatic-inflammation-in-transgenic-mice-with-betacell-expression-of-interferongamma(1536e48b-0895-402d-8a88-d60bd5cd406f).html

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Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells

Autor: Wogensen, L, Ma, Y H, Grodsky, G M, Robertson, R P, Burton, F, Sutcliffe, J G, Sarvetnick, N

Publikováno v: Wogensen, L, Ma, Y H, Grodsky, G M, Robertson, R P, Burton, F, Sutcliffe, J G & Sarvetnick, N 1993, ' Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells ', Molecular and Cellular Endocrinology, vol. 98, no. 1, pp. 33-42 .

Investigation of intracellular pathways of stimulus-secretion signaling in vivo is possible by transgenic expression of agents known to influence specific biochemical interactions in the cells. The objective of the present study was to establish an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::b0308b0126f798d1a3c01baa0689f472
https://pure.au.dk/portal/da/publications/functional-effects-of-transgenic-expression-of-cholera-toxin-in-pancreatic-betacells(e261c7c6-5176-47cb-b105-939385193842).html

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