Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity.

Autor: Sarvestani SK; Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Signs S; Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Hu B; Department of Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Yeu Y; Department of Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Feng H; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Ni Y; Department of Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Hill DR; Department of Internal Medicine, Gastroenterology, University of Michigan, Ann Arbor, MI, 48109, USA., Fisher RC; Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Ferrandon S; Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., DeHaan RK; Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, 44195, USA., Stiene J; Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Cruise M; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, USA., Hwang TH; Department of Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Shen X; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Spence JR; Department of Internal Medicine, Gastroenterology, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA., Huang EH; Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA. Huange2@ccf.org.; Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, 44195, USA. Huange2@ccf.org.

Publikováno v: Nature communications [Nat Commun] 2021 Jan 11; Vol. 12 (1), pp. 262. Date of Electronic Publication: 2021 Jan 11.

A Tissue Engineering Approach to Metastatic Colon Cancer.

Autor: Sarvestani SK; Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA., DeHaan RK; Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA.; Department of Colon and Rectal Surgery, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA., Miller PG; Departments of Biomedical Engineering, Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA., Bose S; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA., Shen X; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA., Shuler ML; Departments of Biomedical Engineering, Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA., Huang EH; Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA.; Department of Colon and Rectal Surgery, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA.

Publikováno v: IScience [iScience] 2020 Oct 20; Vol. 23 (11), pp. 101719. Date of Electronic Publication: 2020 Oct 20 (Print Publication: 2020).

Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids.

Autor: Sarvestani SK; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Signs SA; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lefebvre V; Department of Cell and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, USA., Mack S; Department of Pediatrics Baylor College of Medicine, Houston, Texas, USA., Ni Y; Department of Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Morton A; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA., Chan ER; Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA., Li X; Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Fox P; Department of Cell and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, USA., Ting A; Department of Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Kalady MF; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA., Cruise M; Department of Pathology, Cleveland Clinic, Cleveland, Ohio, USA., Ashburn J; Department of Surgery, Wake Forest School of Medicine, Salem, North Carolina, USA., Stiene J; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lai W; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Liska D; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA., Xiang S; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Huang EH; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Publikováno v: Oncotarget [Oncotarget] 2018 Jun 19; Vol. 9 (47), pp. 28717-28730. Date of Electronic Publication: 2018 Jun 19 (Print Publication: 2018).

Optimum 3D Matrix Stiffness for Maintenance of Cancer Stem Cells Is Dependent on Tissue Origin of Cancer Cells.

Autor: Jabbari E; Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, SC, 29208, United States of America., Sarvestani SK; Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, SC, 29208, United States of America., Daneshian L; Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, SC, 29208, United States of America., Moeinzadeh S; Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, SC, 29208, United States of America.

Publikováno v: PloS one [PLoS One] 2015 Jul 13; Vol. 10 (7), pp. e0132377. Date of Electronic Publication: 2015 Jul 13 (Print Publication: 2015).

Nanostructure formation and transition from surface to bulk degradation in polyethylene glycol gels chain-extended with short hydroxy acid segments.

Autor: Moeinzadeh S; Biomimetic Materials and Tissue Engineering Laboratories, Department of Chemical Engineering, University of South Carolina, Columbia, 29208, United States., Barati D, Sarvestani SK, Karaman O, Jabbari E

Publikováno v: Biomacromolecules [Biomacromolecules] 2013 Aug 12; Vol. 14 (8), pp. 2917-28. Date of Electronic Publication: 2013 Jul 30.