Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sarvesh Jajoo"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 11, Pp 1132-1145 (2009)
Prostate cancer is the most commonly diagnosed and second most lethal malignancy in men, due mainly to a lack of effective treatment for the metastatic disease. A number of recent studies have shown that activation of the purine nucleoside receptor,
Externí odkaz:
https://doaj.org/article/5f84dc4acdee4e5ca3a3c7bf7972f539
Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway.
Autor:
Sandeep Sheth, Sarvesh Jajoo, Tejbeer Kaur, Debashree Mukherjea, Kelly Sheehan, Leonard P Rybak, Vickram Ramkumar
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51655 (2012)
The consumption of foods containing resveratrol produces significant health benefits. Resveratrol inhibits cancer by reducing cell proliferation and metastasis and by inducing apoptosis. These actions could be explained by its ability to inhibit (ERK
Externí odkaz:
https://doaj.org/article/e983ef1192294323b9b9287310f67af8
Autor:
Vikrant Borse, Kelly Sheehan, Srinivasan Tupal, Sarvesh Jajoo, Tejbeer Kaur, Debashree Mukherjea, Sandeep Sheth, Sumana Ghosh, Vickram Ramkumar, Leonard P. Rybak
Publikováno v:
The Journal of Neuroscience. 36:3962-3977
Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea. Recent studies implicate ROS generation in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc05aa1f89ed6f2c47428bc9fada7db9
https://doi.org/10.1523/jneurosci.3111-15.2016
https://doi.org/10.1523/jneurosci.3111-15.2016
Autor:
Vikrant Borse, Kelly Sheehan, Leonard P. Rybak, Sandeep Sheth, Tejbeer Kaur, Debashree Mukherjea, Sarvesh Jajoo, Vickram Ramkumar
Publikováno v:
Antioxidants & Redox Signaling. 19:1863-1876
Aims: Oncogenic microRNAs (miRs) promote tumor growth and invasiveness. One of these, miR-21, contributes to carcinogenesis in prostate and other cancers. In the present study, we tested the hypothesis that NADPH oxidase-dependent reactive oxygen spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cf5aa44b0b8302b6c556662775a3d7
https://doi.org/10.1089/ars.2012.4820
https://doi.org/10.1089/ars.2012.4820
Publikováno v:
Current Neuropharmacology. 9:342-349
Adenosine is produced primarily by the metabolism of ATP and mediates its physiological actions by interacting primarily with adenosine receptors (ARs) on the plasma membranes of different cell types in the body. Activation of these G protein-coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d45d482492480c27138e224f367c7378
https://doi.org/10.2174/157015911795596559
https://doi.org/10.2174/157015911795596559
Autor:
Sandeep Sheth, Tejbeer Kaur, Debashree Mukherjea, Jennifer R. Bunch, Christopher A. Perro, Vickram Ramkumar, Sarvesh Jajoo, Leonard P. Rybak, Kelly Sheehan
Publikováno v:
Antioxidants & Redox Signaling. 14:999-1010
Transient receptor potential vanilloid 1 (TRPV1) is implicated in cisplatin ototoxicity. Activation of this channel by cisplatin increases reactive oxygen species generation, which contribute to loss of outer hair cells in the cochlea. Knockdown of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c301c3ee9d13fd2d3106b2eba8eb0b52
https://doi.org/10.1089/ars.2010.3497
https://doi.org/10.1089/ars.2010.3497
Autor:
Vickram Ramkumar, Kelly Sheehan, Debashree Mukherjea, Sarvesh Jajoo, Leonard P. Rybak, Tejbeer Kaur
Publikováno v:
Antioxidants & Redox Signaling. 13:589-598
Cisplatin produces hearing loss in cancer patients. Reactive oxygen species (ROS) in the cochlea leads to lipid peroxidation, death of outer hair cells (OHCs), and hearing loss. The cochlea expresses a unique isoform of NADPH oxidase, NOX3, which ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0119090a465b63137751d1412e0c5bf
https://doi.org/10.1089/ars.2010.3110
https://doi.org/10.1089/ars.2010.3110
Publikováno v:
The Tohoku Journal of Experimental Medicine. 219:177-186
Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity occur with the use of this agent. This review summarizes recent im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916ec1457eeec81c4a35ab078a107a10
https://doi.org/10.1620/tjem.219.177
https://doi.org/10.1620/tjem.219.177
Autor:
Craig Whitworth, Jennifer R. Bunch, Jeremy G. Turner, Debashree Mukherjea, Vickram Ramkumar, Leonard P. Rybak, Sarvesh Jajoo
Publikováno v:
The Journal of Neuroscience. 28:13056-13065
Cisplatin, a chemotherapeutic agent of choice for the treatment of solid tumors, produces hearing loss in approximately half a million new cancer patients annually in the United States. The hearing loss is due, in part, to increased generation of rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d323f6a26415ca0204296e0f16714a9b
https://doi.org/10.1523/jneurosci.1307-08.2008
https://doi.org/10.1523/jneurosci.1307-08.2008
Publikováno v:
Neuroscience. 151:525-532
Human immunodeficiency virus (HIV)-1 Tat is a multifunctional protein involved in viral replication, inflammation and apoptosis. Tat activates phospholipase C-β (PLC-β), presumably via a pertussis toxin (PTX) sensitive G i protein, which is critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ec1220d9308c8a674fbf97962ef7dc
https://doi.org/10.1016/j.neuroscience.2007.11.010
https://doi.org/10.1016/j.neuroscience.2007.11.010