Synthesis, in silico , in vitro evaluation of furanyl- and thiophenyl-3-phenyl-1 H -indole-2-carbohydrazide derivatives as tubulin inhibitors and anticancer agents.

Autor: Saruengkhanphasit R; Program in Chemical Sciences, Chulabhorn Graduate Institute 54 Kamphaeng Phet 6, Talat Bang Khen, Lak Si Bangkok 10210 Thailand rungrojs@cgi.ac.th +66 25541900 ext. 2629.; Center of Excellence On Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation Bangkok Thailand., Ngiwsara L; Laboratory of Biochemistry, Chulabhorn Research Institute Bangkok 10210 Thailand., Lirdprapamongkol K; Center of Excellence On Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation Bangkok Thailand.; Laboratory of Biochemistry, Chulabhorn Research Institute Bangkok 10210 Thailand., Chatwichien J; Program in Chemical Sciences, Chulabhorn Graduate Institute 54 Kamphaeng Phet 6, Talat Bang Khen, Lak Si Bangkok 10210 Thailand rungrojs@cgi.ac.th +66 25541900 ext. 2629.; Chulabhorn Royal Academy Bangkok 10210 Thailand., Niwetmarin W; Program in Chemical Sciences, Chulabhorn Graduate Institute 54 Kamphaeng Phet 6, Talat Bang Khen, Lak Si Bangkok 10210 Thailand rungrojs@cgi.ac.th +66 25541900 ext. 2629., Eurtivong C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University 447 Si Ayutthaya Road, Ratchathewi Bangkok 10400 Thailand chatchakorn.eur@mahidol.edu +66 26448677-91 ext. 5402., Kittakoop P; Program in Chemical Sciences, Chulabhorn Graduate Institute 54 Kamphaeng Phet 6, Talat Bang Khen, Lak Si Bangkok 10210 Thailand rungrojs@cgi.ac.th +66 25541900 ext. 2629.; Center of Excellence On Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation Bangkok Thailand.; Laboratory of Natural Products, Chulabhorn Research Institute Bangkok 10210 Thailand., Svasti J; Laboratory of Biochemistry, Chulabhorn Research Institute Bangkok 10210 Thailand., Ruchirawat S; Program in Chemical Sciences, Chulabhorn Graduate Institute 54 Kamphaeng Phet 6, Talat Bang Khen, Lak Si Bangkok 10210 Thailand rungrojs@cgi.ac.th +66 25541900 ext. 2629.; Center of Excellence On Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation Bangkok Thailand.; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute Bangkok 10210 Thailand.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 May 28; Vol. 15 (7), pp. 2483-2495. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024).

Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation.

Autor: Jiwacharoenchai N; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand; Genetic Engineering Interdisciplinary Program, Graduate School, Kasetsart University, Bangkok 10900, Thailand., Saruengkhanphasit R; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand., Niwetmarin W; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand., Seetaha S; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand., Choowongkomon K; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand; Center for Advanced Studies in Nanotechnology for Chemical, Food and Agricultural Industries, KU Institute for Advanced Studies, Kasetsart University, Bangkok 10900, Thailand. Electronic address: fsciktc@ku.ac.th., Ruchirawat S; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Commission on Higher Education (CHE), Ministry of Education, Bangkok 10400, Thailand., Eurtivong C; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Commission on Higher Education (CHE), Ministry of Education, Bangkok 10400, Thailand. Electronic address: chatchakorn@cgi.ac.th.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Feb 15; Vol. 58, pp. 128524. Date of Electronic Publication: 2022 Jan 04.

Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition

Autor: Furnival, R.C., Saruengkhanphasit, R., Holberry, H.E., Shewring, J.R., Guerrand, H.D., Adams, H., Coldham, I.

Simple haloaldehydes, including enolisable aldehydes, were found to be suitable for the formation of cyclic products by cascade (domino) condensation, cyclisation, dipolar cycloaddition chemistry. This multi-component reaction approach to heterocycli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::dc33450b625509e916f6ad002c8227af
https://eprints.whiterose.ac.uk/107281/10/c6ob01871h.pdf

Synthesis of the tricyclic core of manzamine A

Autor: Pathak, R.B., Dobson, B.C., Ghosh, N., Ageel, K.A., Alshawish, M.R., Saruengkhanphasit, R., Coldham, I.

An efficient synthetic approach to the core structure of the manzamine alkaloids is reported, particularly in relation to incorporating a one-carbon unit in ring B from which the aldehyde in ircinal A or the beta-carboline unit in manzamine A could p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fedb2a9a82dfe04d6a42ebcafa93650b

Synthesis of Spirocyclic Amines by Using Dipolar Cycloadditions of Nitrones.

Autor: Saruengkhanphasit R; Department of Chemistry, University of Sheffield , Sheffield S3 7HF, U.K., Collier D; Department of Chemistry, University of Sheffield , Sheffield S3 7HF, U.K., Coldham I; Department of Chemistry, University of Sheffield , Sheffield S3 7HF, U.K.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2017 Jun 16; Vol. 82 (12), pp. 6489-6496. Date of Electronic Publication: 2017 Jun 07.