Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sarra Ryan"'
Autor:
Christine J. Harrison, Elli Papaemmanuil, Ellie Butler, Emilio Barretta, Anthony V. Moorman, Daniel Leongamornlert, Andrew McMillan, Nick Morley, Thomas Creasey, Laura Clifton-Hadley, Tobias Menne, Amy A Kirkwood, Clare J. Rowntree, Bela Patel, Adele K. Fielding, Sarra Ryan, David I. Marks, Pip Patrick
Publikováno v:
Haematologica. 107:2051-2063
Despite being predominantly a childhood disease, the incidence of acute lymphoblastic leukemia (ALL) has a second peak in adults aged 60 years and over. These older adults fare extremely poorly with existing treatment strategies and very few studies
Autor:
Christine J. Harrison, James W. Murray, Sarra Ryan, Zoe Hawking, Claire Schwab, Ruth E. Cranston, Daniel Murdy, Anthony V. Moorman, Emily Winterman, Grace Antony, Emilio Barretta, Amir Enshaei, Ellie Butler, Ajay Vora
Publikováno v:
British Journal of Haematology. 196:753-763
While next-generation sequencing technologies provide excellent strategies to screen for newly defined genetic abnormalities of prognostic or therapeutic significance in patients with B-other-acute lymphoblastic leukaemia (ALL), they are not widely a
Autor:
Sarra Ryan, John Peden, Zoya Kingsbury, Claire Schwab, Terena James, Petri Polonen, Martina Mijuskovic, Jennifer Becq, Richard Yim, Ruth Cranston, Dale Hedges, Kathryn Roberts, Charles Mullighan, Ajay Vora, Lisa Russell, Anthony Moorman, David Bentley, Christine Harrison, Mark Ross
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent genetic abnormalities that drive risk-directed treatment strategies. Using current techniques, accurate detection of such aberrations is challenging, due to the rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::934d261bdbd40b8a1197e7b25ad98aba
https://doi.org/10.21203/rs.3.rs-2151721/v1
https://doi.org/10.21203/rs.3.rs-2151721/v1
Autor:
Robin Hollis, Sarra Ryan, Claire Schwab, John Moppett, Amir Enshaei, Matthew Bashton, Christine J. Harrison, Anthony V. Moorman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
In acute lymphoblastic leukaemia, MLPA has been used in research studies to identify clinically relevant copy number abnormality (CNA) profiles. However, in diagnostic settings other techniques are often employed. We assess whether equivalent CNA pro
Autor:
Sirintra Nakjang, Shambhavi Srivastava, Nikos Darzentas, Jana Gazdova, Sarra Ryan, Mark Catherwood, Elizabeth Hodges, Matthew W Jenner, Anthony V. Moorman, Manisha Maurya, James P. Stewart, Nicholas C.P. Cross, David Gonzalez, Laura Chiecchio, Louise Harewood
Publikováno v:
Blood. 138:272-272
Introduction: Molecular diagnostic testing for lymphoproliferative disorders (LPDs) includes detection of clonal immunoglobulin (IG) and/or T cell receptor (TCR) rearrangements, translocations, copy number alterations (CNA) and somatic mutations. To
Autor:
Lucy Chilton, Christopher Wragg, Christine J. Harrison, Michelle Cummins, Anthony V. Moorman, Claire Schwab, Catriona Parker, James W. Murray, John Moppett, Oliver Tunstall, Nicholas Goulden, Stacey Richardson, Alannah Elliott, Sarra Ryan, Ajay Vora, Vaskar Saha
Publikováno v:
Schwab, C, Ryan, S L, Chilton, L, Elliott, A, Murray, J, Richardson, S, Wragg, C, Moppett, J, Cummins, M, Tunstall, O, Parker, C, Saha, V, Goulden, N, Vora, A, Moorman, A V & Harrison, C J 2016, ' EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) : genetic profile and clinical implications ', Blood, vol. 127, no. 18, pp. 2214-2218 . https://doi.org/10.1182/blood-2015-09-670166
The EBF1-PDGFRB gene fusion accounts for 0.5%) at week 14. Two UKALL 2011 patients, positive for EBF1-PDGFRB, received imatinib; 1 died 6 months after a matched unrelated bone marrow transplant as a result of undefined encephalopathy, and the other r
Autor:
Joanna Cheng, Christina Halsey, Matthew Bashton, Paul Sinclair, Shaun Hollern, Helen Marr, Peter Carey, Lars Buechler, Jake Clayton, Rebecca Hanna, Sarra Ryan, Helen J. Blair, Christine J. Harrison, Olaf Heidenreich, Zoe Hawking, Claire Schwab, Anthony V. Moorman, Lisa Jones, Lisa J. Russell
Publikováno v:
Haematologica
Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of cases of childhood precursor B-cell acute lymphoblastic leukemia. These abnormalities are too complex to engineer faithfully in animal mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7d6a3be31ae824af1930e9517a6dab
https://eprints.gla.ac.uk/157726/13/157726.pdf
https://eprints.gla.ac.uk/157726/13/157726.pdf
Autor:
Nick Telford, Nicole Dastugue, Michael R. Stratton, Paul Sinclair, Yang Li, Peter Vandenberghe, Richard J. Q. McNally, Fiona M. Ross, Patricia Jacobs, Nyla A. Heerema, Christine J. Harrison, Julian Borrow, Peter Van Loo, Olivia Joseph, Vikki Rand, Polly Talley, Philip J. Stephens, Bryan D. Young, Claire Schwab, Nick Bown, Mark Maddison, Andrew J. Carroll, Hazel M. Robinson, Anthony V. Moorman, Claudia Haferlach, Elli Papaemmanuil, Mike Griffiths, Peter J. Campbell, Lorraine Gaunt, Ben Robinson, Sarra Ryan, Sara Dyer, Manuel R. Teixeira, Jiqiu Cheng
Publikováno v:
Nature
Changes in gene dosage are a major driver of cancer, known to be caused by a finite, but increasingly well annotated, repertoire of mutational mechanisms1. This can potentially generate correlated copy-number alterations across hundreds of linked gen
Autor:
C. Schwab, Paul Sinclair, S. Hollern, Z. Hawking, A. Vora, J Irving, C.J. Harrison, M. Case, B. Young, E. Schwalbe, R. Cranston, A. Moorman, R. Hanna, M. Bashton, Sarra Ryan
Publikováno v:
HemaSphere. 3:415
Autor:
Julie Irving, Vikki Rand, Jonathan C. Strefford, Sarra Ryan, Hannah M. Ensor, Dino Masic, Helen Parker, Lisa J. Russell, Hazel M. Robinson, Lynne Minto, Paul Sinclair, Anthony V. Moorman, Lisa Jones, Heather Morrison, Claire Schwab, Christine J. Harrison
Publikováno v:
Blood. 117:6848-6855
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) that has a dismal outcome when treated with standard therapy. For improved diagnosis and risk st