Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarra L Ryan"'
Autor:
Yuan Lu, Sarra L Ryan, David J Elliott, Graham R Bignell, P Andrew Futreal, David W Ellison, Simon Bailey, Steven C Clifford
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6159 (2009)
Medulloblastoma is the most common malignant brain tumour of childhood. The identification of critical genes involved in its pathogenesis will be central to advances in our understanding of its molecular basis, and the development of improved therape
Externí odkaz:
https://doaj.org/article/b41022fe00cc4ec689320bfc476e8694
Autor:
Leonardo Gomes de Lima, Edmund Howe, Vijay Pratap Singh, Tamara Potapova, Hua Li, Baoshan Xu, Jemma Castle, Steve Crozier, Christine J. Harrison, Steve C. Clifford, Karen H. Miga, Sarra L. Ryan, Jennifer L. Gerton
Publikováno v:
Cell Genomics, Vol 1, Iss 3, Pp 100064- (2021)
Summary: Centromeric α-satellite repeats represent ∼6% of the human genome, but their length and repetitive nature make sequencing and analysis of those regions challenging. However, centromeres are essential for the stable propagation of chromoso
Externí odkaz:
https://doaj.org/article/d9a43af8e46246b39eeb471796f82966
Autor:
Thomas Creasey, Emilio Barretta, Sarra L. Ryan, Ellie Butler, Amy A. Kirkwood, Daniel Leongamornlert, Elli Papaemmanuil, Pip Patrick, Laura Clifton-Hadley, Bela Patel, Tobias Menne, Andrew K. McMillan, Christine J. Harrison, Clare J. Rowntree, Nick Morley, David I. Marks, Adele K. Fielding, Anthony V. Moorman
Publikováno v:
Haematologica, Vol 107, Iss 9 (2021)
Despite being predominantly a childhood disease, the incidence of acute lymphoblastic leukemia (ALL) has a second peak in adults aged 60 years and over. These older adults fare extremely poorly with existing treatment strategies and very few studies
Externí odkaz:
https://doaj.org/article/8a04be27587840df8c9f2b5d4ebd7f27
Autor:
Paul B. Sinclair, Ruth E. Cranston, Prahlad Raninga, Joanna Cheng, Rebecca Hanna, Zoe Hawking, Steven Hair, Sarra L. Ryan, Amir Enshaei, Sirintra Nakjang, Vikki Rand, Helen J. Blair, Anthony V. Moorman, Olaf Heidenreich, Christine J. Harrison
Publikováno v:
Leukemia. 37:636-649
A common problem in the study of human malignancy is the elucidation of cancer driver mechanisms associated with recurrent deletion of regions containing multiple genes. Taking B-cell acute lymphoblastic leukaemia (B-ALL) and large deletions of 6q [d
Autor:
Sarra L. Ryan, John F. Peden, Zoya Kingsbury, Claire J. Schwab, Terena James, Petri Polonen, Martina Mijuskovic, Jenn Becq, Richard Yim, Ruth E. Cranston, Dale J. Hedges, Kathryn G. Roberts, Charles G. Mullighan, Ajay Vora, Lisa J. Russell, Robert Bain, Anthony V. Moorman, David R. Bentley, Christine J. Harrison, Mark T. Ross
Publikováno v:
Leukemia. 37:518-528
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent genetic abnormalities that drive risk-directed treatment strategies. Using current techniques, accurate detection of such aberrations can be challenging, due to the
Autor:
Claire Schwab, Ruth E. Cranston, Sarra L. Ryan, Ellie Butler, Emily Winterman, Zoe Hawking, Matthew Bashton, Amir Enshaei, Lisa J. Russell, Zoya Kingsbury, John F. Peden, Emilio Barretta, James Murray, Jude Gibson, Andrew C. Hinchliffe, Robert Bain, Ajay Vora, David R. Bentley, Mark T. Ross, Anthony V. Moorman, Christine J. Harrison
Publikováno v:
Leukemia. 37:529-538
Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about 30% B-ALL (B-other-ALL) without well-established chromosomal ch
Autor:
Qingsong Gao, Sarra L Ryan, Ilaria Iacobucci, Pankaj S Ghate, Ruth E Cranston, Claire J Schwab, Abdelrahman H. Elsayed, Lei Shi, Stanley B Pounds, Shaohua Lei, Pradyumna Baviskar, Deqing Pei, Cheng Cheng, Matthew Bashton, Paul B Sinclair, David R Bentley, Mark Ross, Zoya Kingsbury, Terena James, Kathryn G Roberts, Meenakshi Devidas, Yiping Fan, Wenan Chen, Ti-Cheng Chang, Gang Wu, Andrew J. Carroll, Nyla A. Heerema, Virginia Valentine, Marcus B Valentine, Wenjian Yang, Jun J. Yang, Anthony V Moorman, Christine J Harrison, Charles G. Mullighan
Publikováno v:
Blood Journal.
Intrachromosomal amplification of chromosome 21 defines a subtype of high-risk childhood acute lymphoblastic leukemia (iAMP21-ALL) characterized by copy number changes and complex rearrangements of chromosome 21. The genomic basis of iAMP21-ALL and t
Autor:
Steven C. Clifford, Simon Bailey, David W. Ellison, Richard J. Gilbertson, Michael D. Taylor, Meryl E. Lusher, Sarra L. Ryan, Hisham Megahed, Michael Cole, Twala L. Hogg, Debbie Straughton, Janet C. Lindsey, Ed C. Schwalbe
Purpose: Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management.Experimental Design: Minimal mRNA expression signatures diagnostic for the Wnt/Wingless (WNT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3aed8b5900a441fd93cc3091a9f79d
https://doi.org/10.1158/1078-0432.c.6518963
https://doi.org/10.1158/1078-0432.c.6518963
Autor:
Steven C. Clifford, Simon Bailey, David W. Ellison, Richard J. Gilbertson, Michael D. Taylor, Meryl E. Lusher, Sarra L. Ryan, Hisham Megahed, Michael Cole, Twala L. Hogg, Debbie Straughton, Janet C. Lindsey, Ed C. Schwalbe
Supplementary Figures S1-S2; Supplementary Tables S1-S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339fcd694ea58ca74b022b9f2b0faf9b
https://doi.org/10.1158/1078-0432.22442156.v1
https://doi.org/10.1158/1078-0432.22442156.v1
Autor:
Paul. B. Sinclair, Helen H. Blair, Sarra L. Ryan, Lars Buechler, Joanna Cheng, Jake Clayton, Rebecca Hanna, Shaun Hollern, Zoe Hawking, Matthew Bashton, Claire J. Schwab, Lisa Jones, Lisa J. Russell, Helen Marr, Peter Carey, Christina Halsey, Olaf Heidenreich, Anthony V. Moorman, Christine J. Harrison
Publikováno v:
Haematologica, Vol 103, Iss 4 (2018)
Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of cases of childhood precursor B-cell acute lymphoblastic leukemia. These abnormalities are too complex to engineer faithfully in animal mod
Externí odkaz:
https://doaj.org/article/061b963a6e4f465eb098f328b26facdc